The Philadelphia chromosome as seen by fluorescent in situ hybridization (FISH).
Specialty
Haematology and oncology
Frequency
298,000 (2015)[1]
Deaths
32,200 (2015)[2]
Chronic myelogenous leukemia (CML), also known as chronic myeloid leukemia, is a cancer of the white blood cells. It is a form of leukemia characterized by the increased and unregulated growth of myeloid cells in the bone marrow and the accumulation of these cells in the blood. CML is a clonal bone marrow stem cell disorder in which a proliferation of mature granulocytes (neutrophils, eosinophils and basophils) and their precursors is found; characteristic increase in basophils is clinically relevant. It is a type of myeloproliferative neoplasm associated with a characteristic chromosomal translocation called the Philadelphia chromosome.
CML is largely treated with targeted drugs called tyrosine-kinase inhibitors (TKIs) which have led to dramatically improved long-term survival rates since 2001. These drugs have revolutionized treatment of this disease and allow most patients to have a good quality of life when compared to the former chemotherapy drugs. In Western countries, CML accounts for 15–25% of all adult leukemias and 14% of leukemias overall (including the pediatric population, where CML is less common).[3]
^Vos T, Allen C, Arora M, Barber RM, Bhutta ZA, Brown A, et al. (GBD 2015 Disease and Injury Incidence and Prevalence Collaborators) (October 2016). "Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015". Lancet. 388 (10053): 1545–1602. doi:10.1016/S0140-6736(16)31678-6. PMC 5055577. PMID 27733282.
^Wang H, Naghavi M, Allen C, Barber RM, Bhutta ZA, Carter A, et al. (GBD 2015 Mortality and Causes of Death Collaborators) (October 2016). "Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980-2015: a systematic analysis for the Global Burden of Disease Study 2015". Lancet. 388 (10053): 1459–1544. doi:10.1016/s0140-6736(16)31012-1. PMC 5388903. PMID 27733281.
^Cite error: The named reference MSR was invoked but never defined (see the help page).
and 29 Related for: Chronic myelogenous leukemia information
Chronicmyelogenousleukemia (CML), also known as chronic myeloid leukemia, is a cancer of the white blood cells. It is a form of leukemia characterized...
myeloproliferative. Chronicleukemia may refer to: ChronicmyelogenousleukemiaChronic lymphocytic leukemia, including Hairy cell leukemia Myeloproliferative...
Chronic phase chronicmyelogenousleukemia is a phase of chronicmyelogenousleukemia in which 5% or fewer of the cells in the blood and bone marrow are...
production. Chronicmyelogenousleukemia: A cancer of the white blood cells. Acute megakaryoblastic leukemia: A life-threatening leukemia in which malignant...
of acute myeloid leukemia Acute myeloid leukemiaChronicmyelogenousleukemia Peripheral blood stain of chronicmyelogenousleukemia in accelerated phase...
and PDGFR-β. Specifically, it is used for chronicmyelogenousleukemia (CML) and acute lymphocytic leukemia (ALL) that are Philadelphia chromosome–positive...
prevents the promyelocytes from maturing properly. Chronicmyelogenousleukemia (CML) is a chronicleukemia that develops slowly, over months to years. CML...
effective. If imatinib does not work, patients with advanced chronicmyelogenousleukemia can use nilotinib, dasatinib, bosutinib, ponatinib, or another...
associated with ALL and AML. p230 is usually associated with chronicmyelogenousleukemia associated with neutrophilia and thrombocytosis (CML-N). Additionally...
the term "acute leukemia" in 1889 to differentiate rapidly progressive and fatal leukemias from the more indolent chronicleukemias. The term "myeloid"...
synonymously, as for example with chronic myeloid/myelogenousleukemia. In hematopoiesis, myeloid cells, or myelogenous cells are blood cells that arise...
cells. Lymphomas, lymphocytic leukemias, and myeloma are from the lymphoid line, while acute and chronicmyelogenousleukemia, myelodysplastic syndromes...
type, and the cell line is derived from a 53-year-old female chronicmyelogenousleukemia patient in blast crisis. The cells are non-adherent and rounded...
conception); this has been described mainly in leukemia (acute myelogenousleukemia and chronicmyelogenousleukemia). Translocations have also been described...
medication used to treat certain cases of chronicmyelogenousleukemia (CML) and acute lymphoblastic leukemia (ALL). Specifically it is used to treat cases...
and src tyrosine kinase inhibitor used for the treatment of chronicmyelogenousleukemia.[medical citation needed] Originally synthesized by Wyeth, it...
used to treat chronicmyelogenousleukemia (CML) which has the Philadelphia chromosome. It may be used both in initial cases of chronic phase CML as well...
medication used in sickle-cell disease, essential thrombocythemia, chronicmyelogenousleukemia, polycythemia vera, and cervical cancer. In sickle-cell disease...
treatment of acute myeloid leukemia. It is used for treatment of acute lymphoblastic leukemia and chronicmyelogenousleukemia in blast crisis. It is distributed...
acute leukemia. Serum leukocyte alkaline phosphatase is normal or elevated in leukemoid reaction, but is depressed in chronicmyelogenousleukemia. The...
Media, LLC. pp. 28–. ISBN 978-0-387-73744-7. Karp JE (2007). Acute myelogenousleukemia. Humana Press. pp. 385–. ISBN 978-1-58829-621-4. Retrieved 13 November...
and 2002. He and his research group discovered the cause of chronicmyelogenousleukemia and furthered the understanding of the nucleotide excision repair...
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