Tumors of the hematopoietic and lymphoid tissues information
Tumors that affect the blood, bone marrow, lymph, and lymphatic system
Medical condition
Tumors of the hematopoietic and lymphoid tissues
Micrograph of a plasmacytoma, a hematological malignancy
Tumors of the hematopoietic and lymphoid tissues (American English) or tumours of the haematopoietic and lymphoid tissues (British English) are tumors that affect the blood, bone marrow, lymph, and lymphatic system.[1][2] Because these tissues are all intimately connected through both the circulatory system and the immune system, a disease affecting one will often affect the others as well, making aplasia, myeloproliferation and lymphoproliferation (and thus the leukemias and the lymphomas) closely related and often overlapping problems.
While uncommon in solid tumors, chromosomal translocations are a common cause of these diseases. This commonly leads to a different approach in diagnosis and treatment of hematological malignancies.
Hematological malignancies are malignant neoplasms ("cancer"), and they are generally treated by specialists in hematology and/or oncology. In some centers "hematology/oncology" is a single subspecialty of internal medicine while in others they are considered separate divisions (there are also surgical and radiation oncologists). Not all hematological disorders are malignant ("cancerous"); these other blood conditions may also be managed by a hematologist.
Hematological malignancies may derive from either of the two major blood cell lineages: myeloid and lymphoid cell lines. The myeloid cell line normally produces granulocytes, erythrocytes, thrombocytes, macrophages and mast cells; the lymphoid cell line produces B, T, NK and plasma cells. Lymphomas, lymphocytic leukemias, and myeloma are from the lymphoid line, while acute and chronic myelogenous leukemia, myelodysplastic syndromes and myeloproliferative diseases are myeloid in origin.
A subgroup of them are more severe and are known as haematological malignancies (British English)/hematological malignancies (American English) or blood cancer. They may also be referred to as liquid tumors.[3][4]
^Vardiman, JW; Thiele, J; Arber, DA; Brunning, RD; Borowitz, MJ; Porwit, A; Harris, NL; Le Beau, MM; Hellström-Lindberg, E; Tefferi, A; Bloomfield, CD (30 July 2009). "The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: rationale and important changes". Blood. 114 (5): 937–51. doi:10.1182/blood-2009-03-209262. PMID 19357394. S2CID 3101472.
^World Cancer Report 2014. World Health Organization. 2014. pp. Chapter 5.13. ISBN 978-9283204299.
^Juo, Pei-Show (2001). Concise Dictionary of Biomedicine and Molecular Biology (2nd ed.). Hoboken: CRC Press. p. 653. ISBN 9781420041309.
^Cancer Rehabilitation Medicine Quick Reference (RMQR). New York: Demos Medical Publishing. 2013. p. 26. ISBN 9781617050008.
and 26 Related for: Tumors of the hematopoietic and lymphoid tissues information
affect the blood, bone marrow, andlymphoid system, known as tumorsofthehematopoieticandlymphoidtissues. Treatment may involve some combination of chemotherapy...
(90% of cases) and Hodgkin lymphoma (HL) (10%). Lymphomas, leukemias and myelomas are a part ofthe broader group oftumorsofthehematopoieticand lymphoid...
consists of a large network of lymphatic vessels, lymph nodes, lymphoid organs, lymphatic tissueand lymph. Lymph is a clear fluid carried by the lymphatic...
the medullary cavity. All types ofhematopoietic cells, including both myeloid andlymphoid lineages, are created in bone marrow; however, lymphoid cells...
adaptive immunity), and innate lymphoid cells (ILCs; "innate T cell-like" cells involved in mucosal immunity and homeostasis), of which natural killer...
tumors ofthehematopoieticandlymphoidtissues. The WHO International Working Group on Morphology of MDS (IWGM-MDS) defined three types of sideroblasts:[citation...
ILCs are primarily tissue resident cells, found in both lymphoid (immune associated), and non- lymphoidtissues, and rarely in the blood. They are particularly...
of cartilage, bone, blood and lymph. Other kinds of connective tissues include fibrous, elastic, andlymphoid connective tissues. Fibroareolar tissue...
ofHematopoieticandLymphoidTissues. 2001, p. 2001.) Boonhat H, Lin RT (December 2020). "Association between leukemia incidence and mortality and residential...
formerly known as tumor necrosis factor-beta (TNF-β) is a protein that in humans is encoded by the LTA gene. Belonging to thehematopoietic cell line, LT-α...
(neutrophils, monocytes, eosinophils and basophils) are distinguished from lymphoid cells (lymphocytes) by hematopoietic lineage (cellular differentiation...
(also called MALToma) is a form of lymphoma involving the mucosa-associated lymphoidtissue (MALT), frequently ofthe stomach, but virtually any mucosal...
among the types. Lymphoid and myeloid DCs evolve from lymphoidand myeloid precursors, respectively, and thus are ofhematopoietic origin. By contrast, follicular...
peptides by type 2 innate lymphoid cells in response to interleukin 33. Due to the complex nature of adipose tissueand a growing list of browning regulatory...
use of a liquid, semi-solid, or solid growth medium, such as broth or agar. Tissue culture commonly refers to the culture of animal cells andtissues, with...
bloodstream andthe lymph to peripheral lymphoidtissues, such as a spleen, lymph nodes, tonsils and mucosal tissues. Once in a secondary lymphoid organ the B cell...
from the bone-marrow hematopoietic stem cell, but are of mesenchymal origin. Possible functions of FDC include: organizing lymphoidtissue's cells and microarchitecture...
type of cell. In mammals, they include, among others, hematopoietic stem cells, which replenish blood and immune cells, basal cells, which maintain the skin...
exodus-2, and secondary lymphoid-tissue chemokine (SLC). CCL21 elicits its effects by binding to a cell surface chemokine receptor known as CCR7. The main...
produce and/or primarily host hematopoietic cells and includes bone marrow, the lymph nodes, thymus, spleen, and other lymphoidtissues. In the United...
Global Information