This article is about a type of blood cell. For the endocrine cell of the anterior pituitary, see basophil cell.
Basophil
3D rendering of a basophil
Dyed basophil among red blood cells
Details
System
Immune system
Identifiers
MeSH
D001491
TH
H2.00.04.1.02022
FMA
62862
Anatomical terms of microanatomy
[edit on Wikidata]
Basophils are a type of white blood cell. Basophils are the least common type of granulocyte, representing about 0.5% to 1% of circulating white blood cells.[1] However, they are the largest type of granulocyte and how they work is not fully understood.[citation needed] They are responsible for inflammatory reactions during immune response, as well as in the formation of acute and chronic allergic diseases, including anaphylaxis, asthma, atopic dermatitis and hay fever.[2] They also produce compounds that coordinate immune responses, including histamine and serotonin that induce inflammation, and heparin that prevents blood clotting,[3] although there are less than that found in mast cell granules.[4] Mast cells were once thought to be basophils that migrated from the blood into their resident tissues (connective tissue), but they are now known to be different types of cells.[5]
Basophils were discovered in 1879 by German physician Paul Ehrlich, who one year earlier had found a cell type present in tissues that he termed mastzellen (now mast cells).[6] Ehrlich received the 1908 Nobel Prize in Physiology or Medicine for his discoveries.
The name comes from the fact that these leukocytes are basophilic, i.e., they are susceptible to staining by basic dyes, as shown in the picture.
^"Blood differential test". Medline Plus. U.S. National Library of Medicine. Archived from the original on 21 April 2016. Retrieved 22 April 2016.
^Mukai K, Galli SJ (2013). "Basophils". Vol. Online. doi:10.1002/9780470015902.a0001120.pub3. ISBN 978-0470016176. Archived from the original on 2016-05-01. {{cite book}}: |journal= ignored (help); Missing or empty |title= (help)
^Khurana (2009). Textbook Of Medical Physiology (2nd ed.). Elsevier. p. 180. ISBN 978-81-8147-850-4. Archived from the original on 2018-05-04.
^Stone KD, Prussin C, Metcalfe DD (February 2010). "IgE, mast cells, basophils, and eosinophils". The Journal of Allergy and Clinical Immunology. 125 (2 Suppl 2): S73-80. doi:10.1016/j.jaci.2009.11.017. PMC 2847274. PMID 20176269.
^Franco CB, Chen CC, Drukker M, Weissman IL, Galli SJ (April 2010). "Distinguishing mast cell and granulocyte differentiation at the single-cell level". Cell Stem Cell. 6 (4): 361–8. doi:10.1016/j.stem.2010.02.013. PMC 2852254. PMID 20362540.
^Blank U, Falcone FH, Nilsson G (September 2013). "The history of mast cell and basophil research - some lessons learnt from the last century". Allergy. 68 (9): 1093–101. doi:10.1111/all.12197. PMID 23991682. S2CID 31710697.
Basophils are a type of white blood cell. Basophils are the least common type of granulocyte, representing about 0.5% to 1% of circulating white blood...
of white blood cells are granulocytes (neutrophils, eosinophils, and basophils), and agranulocytes (monocytes, and lymphocytes (T cells and B cells))...
An anterior pituitary basophil is a type of cell in the anterior pituitary which manufactures hormones. It is called a basophil because it is basophilic...
Specifically, this term refers to: basophil granulocytes anterior pituitary basophils An abnormal increase in basophil granulocytes is therefore also described...
Basophilia is the condition of having greater than 200 basophils/μL in the venous blood. Basophils are the least numerous of the myelogenous cells, and...
cells, where one may also find basophils and acidophils. Microanatomy of the pars distalis showing chromophobes, basophils, and acidophils Eosinophilic...
activated basophils and mast cells, that may lead to shock with laryngeal edema, lower-airway obstruction and hypotension. This is why basophils are considered...
and function to the basophil, another type of white blood cell. Although mast cells were once thought to be tissue-resident basophils, it has been shown...
the most abundant of the granulocytes; the other types (eosinophils, basophils, and mast cells) have varying morphology. Granulocytes are produced via...
parasites and certain infections in vertebrates. Along with mast cells and basophils, they also control mechanisms associated with allergy and asthma. They...
homeopathic dilutions of histamine exerted an effect on the activity of basophils. In response to the first of these studies, Horizon aired a programme...
development), and Gfi1 (promotes Th2 development and inhibits Th1) or IRF8 (basophils and mast cells). Significantly, certain factors elicit different responses...
immune response of mast cells and human basophil cells in several ways. Inhibition of the mast cell and human basophil immune response by involvement of ectokinase...
distinguished from each other (though they can be distinguished from basophils and chromophobes), and are therefore identified simply as "acidophils"...
Bruce (2002). Molecular biology of the cell (4th ed.). New York [u.a.]: Garland. pp. 1284–1290. ISBN 0815340729. "Basophil". medcell.med.yale.edu. v t e...
form part of the polymorphonuclear cells family (PMNs) together with basophils and eosinophils. The name neutrophil derives from staining characteristics...
multilobed nuclei, are three short lived cell types including eosinophils, basophils, and neutrophils. A granulocyte differentiates into a distinct cell type...
basocytopenia) is a form of agranulocytosis associated with a deficiency of basophils. It has been proposed as an indicator of ovulation. It is difficult to...
his findings in 1932 as "The Basophil Adenomas of the Pituitary Body and Their Clinical Manifestations: pituitary Basophilism". Cushing was elected to the...
of an immune response to foreign pathogens, histamine is produced by basophils and by mast cells found in nearby connective tissues. Histamine increases...
on mast cells and basophils. It lacks the beta subunit on other cells. It is constitutively expressed on mast cells and basophils and is inducible in...
antibody remained in the water solution. Nonetheless, they reported, human basophils responded to the solutions just as though they had encountered the original...
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