The MRN complex (MRX complex in yeast) is a protein complex consisting of Mre11, Rad50 and Nbs1 (also known as Nibrin[1] in humans and as Xrs2 in yeast). In eukaryotes, the MRN/X complex plays an important role in the initial processing of double-strand DNA breaks prior to repair by homologous recombination or non-homologous end joining. The MRN complex binds avidly to double-strand breaks both in vitro and in vivo and may serve to tether broken ends prior to repair by non-homologous end joining or to initiate DNA end resection prior to repair by homologous recombination. The MRN complex also participates in activating the checkpoint kinase ATM in response to DNA damage.[2][3] Production of short single-strand oligonucleotides by Mre11 endonuclease activity has been implicated in ATM activation by the MRN complex.[4]
^"Atlas of Genetics and Cytogenetics in Oncology and Haematology - NBS1". Retrieved 2008-02-12.
^Lee, JH; Paull, TT (Apr 2, 2004). "Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex". Science. 304 (5667): 93–6. Bibcode:2004Sci...304...93L. doi:10.1126/science.1091496. PMID 15064416. S2CID 26732864.
^Lee, JH; Paull, TT (Apr 22, 2005). "ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex". Science. 308 (5721): 551–4. Bibcode:2005Sci...308..551L. doi:10.1126/science.1108297. PMID 15790808. S2CID 37711373.
^Jazayeri A, Balestrini A, Garner E, Haber JE, Costanzo V (2008). "Mre11-Rad50-Nbs1-dependent processing of DNA breaks generates oligonucleotides that stimulate ATM activity". The EMBO Journal. 27 (14): 1953–1962. doi:10.1038/emboj.2008.128. PMC 2453060. PMID 18596698.
The MRNcomplex (MRX complex in yeast) is a protein complex consisting of Mre11, Rad50 and Nbs1 (also known as Nibrin in humans and as Xrs2 in yeast)...
MRN may refer to: Macquarie Media (ASX: MRN), an Australian media company Michigan Radio Network, a satellite-distributed news service in Michigan, U...
repair pathway, the MRNcomplex (which consists of Mre11, Rad50 and NBS1) is attracted to the broken DNA ends and other MRNcomplexes to keep the broken...
another MRNcomplex, the MDC1 protein can sense the DNA damage by binding to the γH2AX flag through its BRCT domain and brings the bound MRNcomplex to the...
NBS1/hMre11/RAD50(N/M/R, more commonly referred to as MRN) double strand DNA break repair complex. This complex recognizes DNA damage and rapidly relocates to...
interactions between NBS1 and MDC1 mediate chromatin retention of the MRNcomplex at sites of DNA damage". EMBO Rep. 9 (8): 795–801. doi:10.1038/embor...
mutants defective in Ppmre11 or Pprad50 (that encode key proteins of the MRNcomplex, the principal sensor of DNA double-strand breaks) showed that these...
where this complex is called the MRX complex). Before resection can start, CtBP1-interacting protein (CtIP) needs to bind to the MRNcomplex so that the...
first several steps. After a double-strand break occurs, the MRX complex (MRNcomplex in humans) binds to DNA on either side of the break. Next a resection...
DNA contributes to its ability to inhibit the nuclease activity of the MRNcomplex as well as the nuclease activity of Mre11 alone. This may explain a role...
a budding yeast homolog of the mammalian Mre11-Rad50-Nbs1 (MRN) DNA damage repair complex. Cells are able to accurately repair DNA double-strand breaks...
assemble on the extensive γH2AX-modified chromatin are the MRNcomplex (a protein complex consisting of Mre11, Rad50 and Nbs1), RAD51 and the ATM kinase...
break repair. This protein forms a complex with MRE11 and NBS1 (also known as Xrs2 in yeast). This MRNcomplex (MRX complex in yeast) binds to broken DNA ends...
two known substrates for this ubiquitin ligases; p53 and the MRNcomplex. The MRNcomplex, if not bound by the E1B-55K/E4orf6 ubiquitin ligase, will treat...
that provide a platform to recruit proteins involved in HRR repair. The MRNcomplex, consisting of Mre11, Rad50 and NBS1, carries out the initial steps of...
integrity. Genes Ppmre11 and Pprad50 of P. patens encode components of the MRNcomplex, the principal sensor of DNA double-strand breaks. These genes are necessary...
the protein mutated in AT, ATM, interacts with the MRE11/RAD50/NBS1 (MRN) complex. Other syndromes with clinical features similar to Nijmegen Breakage...
kinase found in colorectal cancer. WDCP has also been identified in the MRNcomplex, which processes double-stranded breaks in DNA. WDCP is located in chromosome...
which is a mutation in the damage response kinase ATM – and BRCA1 or MRNcomplex mutations that play a role in responding to DNA damage. When the above...
the SOSS complex, a multiprotein complex that functions downstream of the MRNcomplex to promote DNA repair and G2/M checkpoint. The SOSS complex associates...
the race for MRN when the field races thru the tri-oval. Dave Moody called the action from turn 1, Mike Bagley called the action for MRN when the field...
which relies on DMC1, fails. MCM8 forms a complex with MCM9 that is required for DNA resection by the MRNcomplex (MRE11-RAD50-NBS1) at double strand breaks...
Larry McReynolds provided insight from the Fox Sports studio in Charlotte. MRN had the radio call for the race which was also simulcasted on Sirius XM NASCAR...
doi:10.1016/j.quascirev.2023.108162. "Lexique du substrat rocheux". dnr-mrn.gnb.ca. Retrieved 22 December 2019. "A mid-Darriwilian super volcano in northern...
adjacent promoter. For AAV, the hairpins can bind to MRE11/Rad50/NBS1 (MRN) complexes and Ku70/80 heterodimers, which are involved in sensing and repairing...
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