Chromatin remodeling is the dynamic modification of chromatin architecture to allow access of condensed genomic DNA to the regulatory transcription machinery proteins, and thereby control gene expression. Such remodeling is principally carried out by 1) covalent histone modifications by specific enzymes, e.g., histone acetyltransferases (HATs), deacetylases, methyltransferases, and kinases, and 2) ATP-dependent chromatin remodeling complexes which either move, eject or restructure nucleosomes.[1] Besides actively regulating gene expression, dynamic remodeling of chromatin imparts an epigenetic regulatory role in several key biological processes, egg cells DNA replication and repair; apoptosis; chromosome segregation as well as development and pluripotency. Aberrations in chromatin remodeling proteins are found to be associated with human diseases, including cancer. Targeting chromatin remodeling pathways is currently evolving as a major therapeutic strategy in the treatment of several cancers.
^Teif VB, Rippe K (September 2009). "Predicting nucleosome positions on the DNA: combining intrinsic sequence preferences and remodeler activities". Nucleic Acids Research. 37 (17): 5641–55. doi:10.1093/nar/gkp610. PMC 2761276. PMID 19625488.
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eukaryotic histones. ChromatinRemodeling: Chromatinremodeling can result from covalent modification of histones that physically remodel, move or remove nucleosomes...
distinct reactions are associated with the term ATP-dependent chromatinremodeling. Remodeling enzymes have been shown to slide nucleosomes along DNA, disrupt...
recruitment and activation of the chromatinremodeling protein, ALC1, that can cause nucleosome remodeling. Nucleosome remodeling has been found to cause, for...
of the five major DNA chromatinremodeling complex types, or subfamilies, found in most eukaryotic organisms. ISWI remodeling complexes place nucleosomes...
manipulate chromatin structure and lay an epigenetic framework makes them essential in cell maintenance and survival. The process of chromatinremodeling involves...
histones H2A, H2B, H3 and H4, to form chromatin. H2AX contributes to nucleosome-formation, chromatin-remodeling and DNA repair, and is also used in vitro...
Nucleosome Remodeling Factor (NURF) is an ATP-dependent chromatinremodeling complex first discovered in Drosophila melanogaster (fruit fly) that catalyzes...
predisposes children to malignancies. INI1/hSNF5, a component of the chromatinremodeling SWI/SNF complex, is a critical tumor suppressor biallelically inactivated...
called chromatinremodeling. Chromatinremodeling is one apparatus through which epigenetics acts. There are three mechanisms of chromatinremodeling that...
residues commonly found in proteins associated with the remodeling and manipulation of chromatin. The domain is highly conserved among both plants and animals...
by altering the chromatin structure around those genes. The protein encoded by this gene is a component of the chromatinremodeling and spacing factor...
ATP-dependent 'chromatin' or 'nucleosome' remodeling factor that in humans is encoded by the CHD7 gene. CHD7 is an ATP-dependent chromatinremodeler homologous...
recruitment of chromatinremodeling complexes by the binding of activator molecules to corresponding enhancer regions. The nucleosome remodeling complexes...
mammalian SWI/SNF complex, a large molecular machine known as a Chromatinremodeling complex. She was named as one of the world's leading scientists by...
/ helicase domain, and thus it belongs to the SWI/SNF family of chromatinremodeling proteins. ATRX is required for deposition of the histone variant...
of action. To allow DNA repair, the chromatin must be remodeled. In eukaryotes, ATP dependent chromatinremodeling complexes and histone-modifying enzymes...
trimethylation regulates gene expression through chromatinremodeling by the NURF complex. This makes the DNA in the chromatin more accessible for transcription factors...
by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatinremodelling complex SWI/SNF,...
encoded by the ARID1B gene. ARID1B is a component of the human SWI/SNF chromatinremodeling complex. Germline mutations in ARID1B are associated with Coffin–Siris...
ribose chain) on DDB2 that attracts the DNA remodeling protein ALC1. Action of ALC1 relaxes the chromatin at the site of UV damage to DNA. This relaxation...
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