Mediator of DNA damage checkpoint protein 1 is a 2080 amino acid long protein that in humans is encoded by the MDC1 gene[5][6][7] located on the short arm (p) of chromosome 6. MDC1 protein is a regulator of the Intra-S phase and the G2/M cell cycle checkpoints and recruits repair proteins to the site of DNA damage. It is involved in determining cell survival fate in association with tumor suppressor protein p53.
This protein also goes by the name Nuclear Factor with BRCT Domain 1 (NFBD1).
^ abcGRCm38: Ensembl release 89: ENSMUSG00000061607 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Ozaki T, Nagase T, Ichimiya S, Seki N, Ohiri M, Nomura N, Takada N, Sakiyama S, Weber BL, Nakagawara A (Sep 2000). "NFBD1/KIAA0170 is a novel nuclear transcriptional transactivator with BRCT domain". DNA Cell Biol. 19 (8): 475–485. doi:10.1089/10445490050128403. PMID 10975465.
^Stewart GS, Wang B, Bignell CR, Taylor AM, Elledge SJ (Feb 2003). "MDC1 is a mediator of the mammalian DNA damage checkpoint". Nature. 421 (6926): 961–966. Bibcode:2003Natur.421..961S. doi:10.1038/nature01446. PMID 12607005. S2CID 4410773.
^"Entrez Gene: MDC1 mediator of DNA damage checkpoint 1".
long protein that in humans is encoded by the MDC1 gene located on the short arm (p) of chromosome 6. MDC1 protein is a regulator of the Intra-S phase and...
of a DNA double-strand break. MDC1 (mediator of DNA damage checkpoint protein 1) then binds to γH2AX and the γH2AX/MDC1 complex then orchestrates further...
accumulation of RNF8 protein and the DNA repair protein NBS1 which bind to MDC1 as MDC1 attaches to γH2AX. RNF8 mediates extensive chromatin decondensation,...
response pathway by demethylating the mediator of DNA damage checkpoint 1 (MDC1) protein, and is required for the survival of acute myeloid leukemia. Mutations...
post-meiotic male germ cells ADA2 regulates heterochromatin via translation of the MDC1 gene. Some mutations in the gene for adenosine deaminase cause it not to...
either side of the damage. Gamma H2AX acts as a binding site for the protein MDC1, which in turn recruits key DNA repair proteins (this complex topic is well...
function: phosphorylated linear motif binding. In the case of BRCA1 (and MDC1), the peptide-binding groove lies in a cleft formed by the junction of the...
cell cycle arrest. A class of checkpoint mediator proteins including BRCA1, MDC1, and 53BP1 has also been identified. These proteins seem to be required for...
that the phosphorylation of H2AX is done by ATM and ATR in cooperation with MDC1. It has been suggested that before or while H2AX is involved with the repair...
seconds of irradiation the protein “Mediator of the DNA damage checkpoint 1” (MDC1) specifically attaches to γH2AX. This is accompanied by simultaneous accumulation...
leads to cancer. MRE11 has been shown to interact with: ATM, BRCA1, Ku70, MDC1, NBN, Rad50, and TERF2. Homologous recombination GRCh38: Ensembl release...
PMID 12551934. Stewart GS, Wang B, Bignell CR, Taylor AM, Elledge SJ (Feb 2003). "MDC1 is a mediator of the mammalian DNA damage checkpoint". Nature. 421 (6926):...
telangiectasia mutated (ATM) kinase which phosphorylates Serine 129 of Histone 2A. MDC1, mediator of DNA damage checkpoint 1, binds to the phosphopeptide, and phosphorylation...
neighborhood of C6orf136 are the following: ATAT1, PPP1R10, DHX16, PPP1R18, MDC1, MRPS18B, TUBB, and FLOT1. C6orf136 has a total of 3 different isoforms....
protein complex composed of CIP2A (the protein encoded by KIAA1524 gene), MDC1 and TOPBP1. CIP2A is over-expressed in several common human malignancies...
Stucki M, Falck J, D'Amours D, Rahman D, Pappin D, et al. (February 2003). "MDC1 is required for the intra-S-phase DNA damage checkpoint". Nature. 421 (6926):...
Promotes Non-homologous End Joining Repair by Facilitating Phosphorylation of MDC1 by ATM at Double-Strand Breaks". Molecular Cell. 68 (1): 61–75.e5. doi:10...
required for the maintenance of genomic stability through modulation of MDC1, RPA, and CHK1". Genes & Development. 22 (5): 587–600. doi:10.1101/gad.1627708...
dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Transmembrane protein 217 Textmining STRING 0.556 Uncharaterized SOX-14...
of TPX2 leads to a decrease in the number of ionizing radiation-induced MDC1 foci and γ-H2AX levels. This is supported by the discovery of TPX2 accumulation...
Global Information
