RNF8 information

RNF8
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2CSW, 2PIE, 4AYC, 4ORH, 4WHV
Identifiers
Aliases	RNF8, hring finger protein 8
External IDs	OMIM: 611685; MGI: 1929069; HomoloGene: 2944; GeneCards: RNF8; OMA:RNF8 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	37,394,734 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	29,863,965 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; cerebellar hemisphere; ; left testis; ; right testis; ; ventricular zone; ; islet of Langerhans; ; prefrontal cortex; ; gonad; ; right hemisphere of cerebellum; ; mucosa of esophagus;
	Top expressed in
	primary oocyte; ; secondary oocyte; ; zygote; ; tail of embryo; ; fetal liver hematopoietic progenitor cell; ; maxillary prominence; ; neural layer of retina; ; endocardial cushion; ; mandibular prominence; ; superior cervical ganglion;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein homodimerization activity; histone binding; chromatin binding; metal ion binding; ubiquitin-protein transferase activity; protein binding; ubiquitin protein ligase binding; transferase activity; identical protein binding; zinc ion binding; ubiquitin binding; ubiquitin protein ligase activity;
Cellular component	site of double-strand break; ubiquitin ligase complex; nucleoplasm; chromosome; telomere; midbody; nucleus; cytosol; cytoplasm;
Biological process	response to ionizing radiation; histone H2A ubiquitination; interstrand cross-link repair; ubiquitin-dependent protein catabolic process; protein K63-linked ubiquitination; positive regulation of DNA repair; histone H2A K63-linked ubiquitination; negative regulation of transcription elongation from RNA polymerase II promoter; cellular response to DNA damage stimulus; cell division; protein K48-linked ubiquitination; isotype switching; protein ubiquitination; spermatid development; cell cycle; histone H2B ubiquitination; double-strand break repair via nonhomologous end joining; histone exchange; protein autoubiquitination; double-strand break repair; DNA repair; chromatin organization;
	Sources:Amigo / QuickGO
Orthologs
	9025
	58230
	ENSG00000112130
	ENSMUSG00000090083
	O76064
	Q8VC56
	NM_003958; NM_183078
	NM_021419
	NP_003949; NP_898901
	NP_067394
	Wikidata
View/Edit Human	View/Edit Mouse

E3 ubiquitin-protein ligase RNF8 is an enzyme that in humans is encoded by the RNF8 gene.^[5]^[6]^[7] RNF8 has activity both in immune system functions^[8] and in DNA repair.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000112130 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000090083 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Jun 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Research. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.
^ Seki N, Hattori A, Sugano S, Suzuki Y, Nakagawara A, Ohhira M, Muramatsu M, Hori T, Saito T (Jan 1999). "Isolation, tissue expression, and chromosomal assignment of a novel human gene which encodes a protein with RING finger motif". Journal of Human Genetics. 43 (4): 272–4. doi:10.1007/s100380050088. PMID 9852682.
^ "Entrez Gene: RNF8 ring finger protein 8".
^ Ramachandran S, Chahwan R, Nepal RM, Frieder D, Panier S, Roa S, Zaheen A, Durocher D, Scharff MD, Martin A (2010). "The RNF8/RNF168 ubiquitin ligase cascade facilitates class switch recombination". Proc. Natl. Acad. Sci. U.S.A. 107 (2): 809–14. Bibcode:2010PNAS..107..809R. doi:10.1073/pnas.0913790107. PMC 2818930. PMID 20080757.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000112130 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000090083 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9734811-5] Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Jun 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Research. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.

[pmid9852682-6] Seki N, Hattori A, Sugano S, Suzuki Y, Nakagawara A, Ohhira M, Muramatsu M, Hori T, Saito T (Jan 1999). "Isolation, tissue expression, and chromosomal assignment of a novel human gene which encodes a protein with RING finger motif". Journal of Human Genetics. 43 (4): 272–4. doi:10.1007/s100380050088. PMID 9852682.

[entrez-7] "Entrez Gene: RNF8 ring finger protein 8".

[pmid20080757-8] Ramachandran S, Chahwan R, Nepal RM, Frieder D, Panier S, Roa S, Zaheen A, Durocher D, Scharff MD, Martin A (2010). "The RNF8/RNF168 ubiquitin ligase cascade facilitates class switch recombination". Proc. Natl. Acad. Sci. U.S.A. 107 (2): 809–14. Bibcode:2010PNAS..107..809R. doi:10.1073/pnas.0913790107. PMC 2818930. PMID 20080757.

RNF8 information

and 20 Related for: RNF8 information

RNF8

Chromatin

H2AFX

Chromatin remodeling

Homologous recombination

DNA repair

HERC2

BRCA1

Ubiquitin

Heritability of autism

MDC1

RING finger domain

DTX3L

WRAP53

Retinoid X receptor alpha

RNF14

UBE2E1

UBE2E3

POLD1

UBE2E2