Epitalon information

Epitalon
Names
	IUPAC name (4S)-4-[[(2S)-2-aminopropanoyl]amino]-5-[[(2S)-3-carboxy-1-(carboxymethylamino)-1-oxopropan-2-yl]amino]-5-oxopentanoic acid
	Other names Epithalon; Epithalone; Ala-Glu-Asp-Gly; L-Alanyl-L-glutamyl-L-aspartyl-glycine; UNII-O65P17785G;
Identifiers
CAS Number	307297-39-8;
3D model (JSmol)	Interactive image;
ChemSpider	189872;
MeSH	C421253
PubChem CID	219042;
UNII	O65P17785G;
CompTox Dashboard (EPA)	DTXSID80952957 ;
	InChI InChI=1S/C14H22N4O9/c1-6(15)12(25)17-7(2-3-9(19)20)14(27)18-8(4-10(21)22)13(26)16-5-11(23)24/h6-8H,2-5,15H2,1H3,(H,16,26)(H,17,25)(H,18,27)(H,19,20)(H,21,22)(H,23,24)/t6-,7-,8-/m0/s1 Key: HGHOBRRUMWJWCU-FXQIFTODSA-N;
	SMILES CC(C(=O)NC(CCC(=O)O)C(=O)NC(CC(=O)O)C(=O)NCC(=O)O)N;
Properties
Chemical formula	C14H22N4O9
Molar mass	390.349
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

Epitalon is a synthetic peptide, telomerase activator, and putative anti-aging compound,^[1]^[2] which was identified as the putative active component of a bovine pineal gland extract known as epithalamin.^[3]

Most studies on epitalon and epithalamin have been conducted by the St. Petersburg Institute of Bioregulation and Gerontology, primarily overseen by Vladimir Khavinson, in Russia.^[2]^[4]^[5]^[6]^[7]

^ Khavinson, VKh; Bondarev, IE; Butyugov, AA (2003). "Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells". Bull Exp Biol Med. 135 (6): 590–592. doi:10.1023/a:1025493705728. PMID 12937682. S2CID 7762518.
^ ^a ^b Khavinson, VKh; Kuznik, BI; Tarnovskaia, SI; Lin'kova, NS (2014). "Peptides and CCL11 and HMGB1 as molecular markers of aging: literature review and own data". Adv Gerontol. 27 (3): 399–406. PMID 25826983.
^ Kozina, LS; Arutjunyan, AV; Khavinson, VKh (2007). "Antioxidant properties of geroprotective peptides of the pineal gland". Arch Gerontol Geriatr. 44: 213–216. doi:10.1016/j.archger.2007.01.029. PMID 17317455.
^ Khavinson, VKh; Lin'kova, NS (2012). "Morphofunctional and molecular bases of pineal gland aging". Fizol Cheloveka. 38 (1): 119–127. PMID 22567846.
^ Anisimov, VN; Khavinson, VKh (2009). "The use of peptide bioregulators for cancer prevention: results of 35 years of research experience and perspectives". Vopr Onkol. 55 (3): 291–304. PMID 19670728.
^ Khavinson, VKh (2002). "Peptides and aging". Neuro Endocrinol Lett. 23 (3): 11–144. PMID 12374906.
^ "Top Management". eng.gerontology.ru. St. Petersburg Institute of Bioregulation and Gerontology. Archived from the original on 2018-01-09. Retrieved 2018-01-08.

[pmid12937682-1] Khavinson, VKh; Bondarev, IE; Butyugov, AA (2003). "Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells". Bull Exp Biol Med. 135 (6): 590–592. doi:10.1023/a:1025493705728. PMID 12937682. S2CID 7762518.

[pmid25826983-2] Khavinson, VKh; Kuznik, BI; Tarnovskaia, SI; Lin'kova, NS (2014). "Peptides and CCL11 and HMGB1 as molecular markers of aging: literature review and own data". Adv Gerontol. 27 (3): 399–406. PMID 25826983.

[pmid17317455-3] Kozina, LS; Arutjunyan, AV; Khavinson, VKh (2007). "Antioxidant properties of geroprotective peptides of the pineal gland". Arch Gerontol Geriatr. 44: 213–216. doi:10.1016/j.archger.2007.01.029. PMID 17317455.

[pmid22567846-4] Khavinson, VKh; Lin'kova, NS (2012). "Morphofunctional and molecular bases of pineal gland aging". Fizol Cheloveka. 38 (1): 119–127. PMID 22567846.

[pmid19670728-5] Anisimov, VN; Khavinson, VKh (2009). "The use of peptide bioregulators for cancer prevention: results of 35 years of research experience and perspectives". Vopr Onkol. 55 (3): 291–304. PMID 19670728.

[pmid12374906-6] Khavinson, VKh (2002). "Peptides and aging". Neuro Endocrinol Lett. 23 (3): 11–144. PMID 12374906.

[InstMgmt-7] "Top Management". eng.gerontology.ru. St. Petersburg Institute of Bioregulation and Gerontology. Archived from the original on 2018-01-09. Retrieved 2018-01-08.

Epitalon information

and 4 Related for: Epitalon information

Epitalon

Telomerase

Total inorganic carbon

CO2SYS

Names

IUPAC name (4S)-4-[[(2S)-2-aminopropanoyl]amino]-5-[[(2S)-3-carboxy-1-(carboxymethylamino)-1-oxopropan-2-yl]amino]-5-oxopentanoic acid
Other names Epithalon Epithalone Ala-Glu-Asp-Gly L-Alanyl-L-glutamyl-L-aspartyl-glycine UNII-O65P17785G
Identifiers
CAS Number	307297-39-8
3D model (JSmol)	Interactive image
ChemSpider	189872
MeSH	C421253
PubChem CID	219042
UNII	O65P17785G
CompTox Dashboard (EPA)	DTXSID80952957
InChI InChI=1S/C14H22N4O9/c1-6(15)12(25)17-7(2-3-9(19)20)14(27)18-8(4-10(21)22)13(26)16-5-11(23)24/h6-8H,2-5,15H2,1H3,(H,16,26)(H,17,25)(H,18,27)(H,19,20)(H,21,22)(H,23,24)/t6-,7-,8-/m0/s1 Key: HGHOBRRUMWJWCU-FXQIFTODSA-N
SMILES CC(C(=O)NC(CCC(=O)O)C(=O)NC(CC(=O)O)C(=O)NCC(=O)O)N
Properties
Chemical formula	C₁₄H₂₂N₄O₉
Molar mass	390.349
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references