In cardiology, ventricular remodeling (or cardiac remodeling)[1] refers to changes in the size, shape, structure, and function of the heart. This can happen as a result of exercise (physiological remodeling) or after injury to the heart muscle (pathological remodeling).[2] The injury is typically due to acute myocardial infarction (usually transmural or ST segment elevation infarction), but may be from a number of causes that result in increased pressure or volume, causing pressure overload or volume overload (forms of strain) on the heart. Chronic hypertension, congenital heart disease with intracardiac shunting, and valvular heart disease may also lead to remodeling. After the insult occurs, a series of histopathological and structural changes occur in the left ventricular myocardium that lead to progressive decline in left ventricular performance. Ultimately, ventricular remodeling may result in diminished contractile (systolic) function and reduced stroke volume.
Physiological remodeling is reversible while pathological remodeling is mostly irreversible. Remodeling of the ventricles under left/right pressure demand make mismatches inevitable. Pathologic pressure mismatches between the pulmonary and systemic circulation guide compensatory remodeling of the left and right ventricles. The term "reverse remodeling" in cardiology implies an improvement in ventricular mechanics and function following a remote injury or pathological process.[3][4][5]
Ventricular remodeling may include ventricular hypertrophy, ventricular dilation, cardiomegaly, and other changes. It is an aspect of cardiomyopathy, of which there are many types. Concentric hypertrophy is due to pressure overload, while eccentric hypertrophy is due to volume overload.[6]
^Mihl, C.; Dassen, W. R. M.; Kuipers, H. (2008). "Cardiac remodelling: Concentric versus eccentric hypertrophy in strength and endurance athletes". Netherlands Heart Journal. 16 (4): 129–33. doi:10.1007/BF03086131. PMC 2300466. PMID 18427637.
^Ventricular+remodeling at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
^Yu, Cheuk-Man; Bleeker, Gabe B.; Fung, Jeffrey Wing-Hong; Schalij, Martin J.; Zhang, Qing; Wall, Ernst E. van der; Chan, Yat-Sun; Kong, Shun-Ling; Bax, Jeroen J. (2005-09-13). "Left Ventricular Reverse Remodeling but Not Clinical Improvement Predicts Long-Term Survival After Cardiac Resynchronization Therapy". Circulation. 112 (11): 1580–86. doi:10.1161/circulationaha.105.538272. ISSN 0009-7322. PMID 16144994.
^Ypenburg, Claudia; Bommel, Rutger J. van; Borleffs, C. Jan Willem; Bleeker, Gabe B.; Boersma, Eric; Schalij, Martin J.; Bax, Jeroen J. (2009). "Long-Term Prognosis After Cardiac Resynchronization Therapy Is Related to the Extent of Left Ventricular Reverse Remodeling at Midterm Follow-Up". Journal of the American College of Cardiology. 53 (6): 483–90. doi:10.1016/j.jacc.2008.10.032. PMID 19195605.
^Saavedra, W.Federico; Tunin, Richard S; Paolocci, Nazareno; Mishima, Takayuki; Suzuki, George; Emala, Charles W; Chaudhry, Pervaiz A; Anagnostopoulos, Petros; Gupta, Ramesh C (2002). "Reverse remodeling and enhancedadrenergic reserve from passive externalsupport in experimental dilated heart failure". Journal of the American College of Cardiology. 39 (12): 2069–76. doi:10.1016/s0735-1097(02)01890-9. PMID 12084610.
^Katz, Daniel H.; Beussink, Lauren; Sauer, Andrew J.; Freed, Benjamin H.; Burke, Michael A.; Shah, Sanjiv J. (2013). "Prevalence, Clinical Characteristics, and Outcomes Associated with Eccentric Versus Concentric Left Ventricular Hypertrophy in Heart Failure with Preserved Ejection Fraction". The American Journal of Cardiology. 112 (8): 1158–64. doi:10.1016/j.amjcard.2013.05.061. PMC 3788852. PMID 23810323.
and 25 Related for: Ventricular remodeling information
In cardiology, ventricularremodeling (or cardiac remodeling) refers to changes in the size, shape, structure, and function of the heart. This can happen...
occur as a consequence of ventricularremodeling following a heart attack. Importantly, pathologic and physiologic remodeling engage different cellular...
cardiovascular disease, or high blood pressure. It is one aspect of ventricularremodeling. While LVH itself is not a disease, it is usually a marker for disease...
parts of the septum and ventricular wall and would prove to be the best option amongst the other methods of ventricularremodeling, i.e. Cooley’s linear...
André F, Frey N, Lugenbiel P, Thomas D (October 2021). "Electrical VentricularRemodeling in Dilated Cardiomyopathy". Cells. 10 (10): 2767. doi:10.3390/cells10102767...
aneurysm bigger is advised. Also, ACE Inhibitors seem to prevent Left Ventricularremodeling and aneurysm formation.[citation needed] Blood thinning agents may...
heart failure is associated with left ventricularremodeling, which manifests as gradual increases in left ventricular end-diastolic and end-systolic volumes...
studies have also shown that CRT can decrease mortality, reverse left ventricularremodeling, and improve quality of life, walking distance, and peak oxygen...
the Ross procedure, ventricular aneurysm repair, left ventricularremodeling and Dor procedure, electrophysiology and left ventricular assist device (LVAD)...
block (IRBBB) often involve exercise-induced right ventricularremodeling, increased right ventricular (RV) free wall thickness, especially in athletes...
excessive right ventricular (RV) wall stress during very high volumes of training, which is known to be causing a disproportionate remodeling of RV. In a...
A ventricular septal defect (VSD) is a defect in the ventricular septum, the wall dividing the left and right ventricles of the heart. The extent of the...
to the athlete, and despite some theoretical concerns that the ventricularremodeling might conceivably predispose for serious arrhythmias, no evidence...
will successfully prevent potentially fatal sustained ventricular tachycardia (VT) or ventricular fibrillation VF (VF) in the future. Sometimes a series...
(February 2015). "New therapies for reducing post-myocardial left ventricularremodeling". Annals of Translational Medicine. 3 (2): 20. doi:10.3978/j.issn...
left atrial volume, size, and left ventricular hypertrophy, characteristic of chronic hypertension. All atrial remodeling is related to heterogeneous conduction...
marginally viable ventricular mass may result in superior geometric remodeling thus conferring better performance when faced with ventricular failure. In spite...
perfusion pressure in the glomeruli. It contributes to ventricularremodeling and ventricular hypertrophy of the heart through stimulation of the proto-oncogenes...
promote ventricularremodeling. While this process may acutely compensate for the initial reduction in CPP, the overall process of hypertrophic remodeling is...
encourage ventricular stiffening and remodeling that lead to poor cardiac output seen in HFpEF. There changes are a result of left ventricular muscle hypertrophy...
natriuresis, diuresis, vasodilation, and reductions in preload and ventricularremodeling. It was discovered and developed by Bristol-Myers Squibb but failed...
expression, deposition of extracellular matrix, wall thickening, and ventricularremodeling in a manner that promotes dysfunction. The mechanism by which oxymatrine...
at night An enlarged heart (cardiomegaly) Left ventricular hypertrophy and left ventricularremodeling Diminished coronary flow reserve and silent myocardial...
Importantly, right ventricularremodeling is associated with increased apoptosis; this is in contrast to pulmonary vascular remodeling which involves inhibition...
resuscitation measure for cardiac arrest associated with ventricular fibrillation and pulseless ventricular tachycardia.) Pharmacologic cardioversion, also called...
Global Information