RNA polymerase II cis-regulatory region sequence-specific DNA binding
Cellular component
nucleoplasm
cytosol
nucleus
protein-containing complex
Biological process
regulation of transcription, DNA-templated
transcription, DNA-templated
positive regulation of transcription by RNA polymerase II
mRNA transcription by RNA polymerase II
regulation of transcription by RNA polymerase II
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
7024
21422
Ensembl
ENSG00000135457
ENSMUSG00000009733
UniProt
Q12800
Q9ERA0
RefSeq (mRNA)
NM_005653 NM_001173452 NM_001173453
NM_001289603 NM_033476 NM_001355497
RefSeq (protein)
NP_001166923 NP_001166924 NP_005644
NP_001276532 NP_258437 NP_001342426
Location (UCSC)
Chr 12: 51.09 – 51.17 Mb
Chr 15: 100.4 – 100.45 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Alpha-globin transcription factor CP2 is a protein that in humans is encoded by the TFCP2 gene.[5][6]
TFCP2 is also called Late SV40 factor (LSF) and it is induced by well-known oncogene AEG-1.[7] LSF also acts as an oncogene in hepatocellular carcinoma.[8] LSF enhances angiogenesis by transcriptionally up-regulating matrix metalloproteinase-9 (MMP9).[9]
Along with its main oncogene function in hepatocellular carcinoma (HCC), it plays multifaceted role in chemoresistance, epithelial-mesenchymal transition (EMT), allergic response, inflammation and Alzheimer's disease.[8][10] The small molecule FQI1 (factor quinolinone inhibitor 1) prevents LSF from binding with HCC DNA, which results in HCC cell death.[8][10][11]
^ abcGRCh38: Ensembl release 89: ENSG00000135457 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000009733 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Swendeman SL, Spielholz C, Jenkins NA, Gilbert DJ, Copeland NG, Sheffery M (Apr 1994). "Characterization of the genomic structure, chromosomal location, promoter, and development expression of the alpha-globin transcription factor CP2". The Journal of Biological Chemistry. 269 (15): 11663–71. doi:10.1016/S0021-9258(19)78176-9. PMID 8157699.
^"Entrez Gene: TFCP2 transcription factor CP2".
^Yoo BK, Gredler R, Vozhilla N, Su ZZ, Chen D, Forcier T, Shah K, Saxena U, Hansen U, Fisher PB, Sarkar D (Aug 2009). "Identification of genes conferring resistance to 5-fluorouracil". Proceedings of the National Academy of Sciences of the United States of America. 106 (31): 12938–43. Bibcode:2009PNAS..10612938Y. doi:10.1073/pnas.0901451106. PMC 2722317. PMID 19622726.
^ abcYoo BK, Emdad L, Gredler R, Fuller C, Dumur CI, Jones KH, Jackson-Cook C, Su ZZ, Chen D, Saxena UH, Hansen U, Fisher PB, Sarkar D (May 2010). "Transcription factor Late SV40 Factor (LSF) functions as an oncogene in hepatocellular carcinoma". Proceedings of the National Academy of Sciences of the United States of America. 107 (18): 8357–62. Bibcode:2010PNAS..107.8357Y. doi:10.1073/pnas.1000374107. PMC 2889542. PMID 20404171.
^Santhekadur PK, Gredler R, Chen D, Siddiq A, Shen XN, Das SK, Emdad L, Fisher PB, Sarkar D (Jan 2012). "Late SV40 factor (LSF) enhances angiogenesis by transcriptionally up-regulating matrix metalloproteinase-9 (MMP-9)". The Journal of Biological Chemistry. 287 (5): 3425–32. doi:10.1074/jbc.M111.298976. PMC 3270996. PMID 22167195.
^ abSanthekadur PK, Rajasekaran D, Siddiq A, Gredler R, Chen D, Schaus SC, Hansen U, Fisher PB, Sarkar D (2012). "The transcription factor LSF: a novel oncogene for hepatocellular carcinoma" (PDF). Am J Cancer Res. 2 (3): 269–285. PMC 3365805. PMID 22679558.
^Grant TJ, Bishop JA, Christadore LM, Barot G, Chin HG, Woodson S, Kavouris J, Siddiq A, Gredler R, Shen XN, Sherman J, Meehan T, Fitzgerald K, Pradhan S, Briggs LA, Andrews WH, Sarkar D, Schaus SE, Hansen U (Mar 2012). "Antiproliferative small-molecule inhibitors of transcription factor LSF reveal oncogene addiction to LSF in hepatocellular carcinoma". Proceedings of the National Academy of Sciences of the United States of America. 109 (12): 4503–8. Bibcode:2012PNAS..109.4503G. doi:10.1073/pnas.1121601109. PMC 3311344. PMID 22396589.
transcription factor CP2 is a protein that in humans is encoded by the TFCP2 gene. TFCP2 is also called Late SV40 factor (LSF) and it is induced by well-known...
research group focuses on the study of transcription factor LSF (also known as TFCP2). Hansen received her bachelor's degree in 1974 from Oberlin College and...
that by definition contain neoplastic cells that express the EWSR1-TFCP2 or FUS-TFCP2 fusion gene. Simple bone cyst (also termed unicameral bone cysts):...
ENSG00000090447 bHLH Known motif – High-throughput in vitro [940] VWCAGCTGWB TFCP2 ENSG00000135457 Grainyhead Known motif – High-throughput in vitro [941]...
vertebrates. Thymidylate synthase is induced by a transcription factor LSF/TFCP2 and LSF is an oncogene in hepatocellular carcinoma. LSF and Thymidylate...
interact with, and suppress the activity of, transcription factor CP2 (TFCP2/CP2). Studies of the mouse counterpart suggested the involvement of this...
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