MS100a7a15 information

The S100 calcium-binding protein mS100a7a15 is the murine ortholog of human S100A7 (Psoriasin) and human S100A15 (Koebnerisin). mS100a7a15 is also known as S100a15, mS100a7 and mS100a7a and is encoded by the mS100a7a gene (alias: S100a15)^[1]^[2]

S100 proteins are a diverse calcium-binding family that mediate fundamental cellular and extracellular processes including cell proliferation and differentiation, cell migration, and the antimicrobial host defense as antimicrobial peptides.

mS100a7a15 was first cloned as mS100a15 from adult mouse skin (FVB/N mice, clone RP1-128L15, accession no.: AL591704).^[2] Today, the protein is of further interest because of its role in innate immunity, epidermal cell maturation and epithelial tumorigenesis. Additionally, it can serve as surrogate model to study hS100A7 and hS100A15 functions.

^ "Entrez Gene: S100 calcium binding protein A7A".
^ ^a ^b Wolf, R; Voscopoulos, CJ; FitzGerald, PC; Goldsmith, P; Cataisson, C; Gunsior, M; Walz, M; Ruzicka, T; Yuspa, SH (July 2006). "The mouse S100A15 ortholog parallels genomic organization, structure, gene expression, and protein-processing pattern of the human S100A7/A15 subfamily during epidermal maturation". The Journal of Investigative Dermatology. 126 (7): 1600–8. doi:10.1038/sj.jid.5700210. PMID 16528363.

[entrez_human-1] "Entrez Gene: S100 calcium binding protein A7A".

[Wolf2006-2] Wolf, R; Voscopoulos, CJ; FitzGerald, PC; Goldsmith, P; Cataisson, C; Gunsior, M; Walz, M; Ruzicka, T; Yuspa, SH (July 2006). "The mouse S100A15 ortholog parallels genomic organization, structure, gene expression, and protein-processing pattern of the human S100A7/A15 subfamily during epidermal maturation". The Journal of Investigative Dermatology. 126 (7): 1600–8. doi:10.1038/sj.jid.5700210. PMID 16528363.