A DNA vaccine is a type of vaccine that transfects a specific antigen-coding DNA sequence into the cells of an organism as a mechanism to induce an immune response.[1][2]
DNA vaccines work by injecting genetically engineered plasmid containing the DNA sequence encoding the antigen(s) against which an immune response is sought, so the cells directly produce the antigen, thus causing a protective immunological response.[3] DNA vaccines have theoretical advantages over conventional vaccines, including the "ability to induce a wider range of types of immune response".[4] Several DNA vaccines have been tested for veterinary use.[3] In some cases, protection from disease in animals has been obtained, in others not.[3] Research is ongoing over the approach for viral, bacterial and parasitic diseases in humans, as well as for cancers.[4] In August 2021, Indian authorities gave emergency approval to ZyCoV-D. Developed by Cadila Healthcare, it is the first DNA vaccine approved for humans.[5]
^Henrique Roman Ramos and Paulo Lee Ho. "Developing Snake Antivenom Sera by Genetic Immunization: A Review". Clinical Toxinology in Asia Pacific and Africa. 2: 401–414.
^Liu S, Wang S, Lu S (April 2016). "DNA immunization as a technology platform for monoclonal antibody induction". Emerging Microbes & Infections. 5 (4): e33. doi:10.1038/emi.2016.27. PMC 4855071. PMID 27048742.
A DNAvaccine is a type of vaccine that transfects a specific antigen-coding DNA sequence into the cells of an organism as a mechanism to induce an immune...
of interaction with the genomic DNA. While some messenger RNA vaccines, such as the Pfizer–BioNTech COVID-19 vaccine, have the disadvantage of requiring...
infected. There are other vaccine candidates in development including live attenuated, inactivated, DNA and subunit vaccines. In December 2018, Dengvaxia...
Marburg virus vaccine was conducted in 2014. The study tested a DNAvaccine and concluded that individuals inoculated with the vaccine exhibited some...
the vaccine needs to minimize the possibility of antibody-dependent enhancement of dengue virus infection. As of March 31, 2017 a DNAvaccine has been...
not been linked to Guillain–Barré syndrome. Hepatitis B vaccines are produced with recombinant DNA techniques and contain immunologic adjuvant. They are...
papillomavirus (HPV) vaccines are vaccines that prevent infection by certain types of human papillomavirus (HPV). Available HPV vaccines protect against either...
an HCV vaccine has presented challenges. No vaccine is currently available, but several vaccines are currently under development. Most vaccines work through...
The DNAVaccine, according to an article of the Journal of Preventive, Diagnostic and Treatment Strategies in Medicine ( September, 2022) "DNAVaccine Construct...
A viral vector vaccine is a vaccine that uses a viral vector to deliver genetic material (DNA) that can be transcribed by the recipient's host cells as...
Bacillus Calmette–Guérin (BCG) vaccine is a vaccine primarily used against tuberculosis (TB). It is named after its inventors Albert Calmette and Camille...
Genetic vaccines thus include DNAvaccines, RNA vaccines and viral vector vaccines. Most vaccines other than live attenuated vaccines and genetic vaccines are...
Influenza vaccines, colloquially known as flu shots, are vaccines that protect against infection by influenza viruses. New versions of the vaccines are developed...
[non-primary source needed] DNAvaccine approaches for dental cavities have had a history of success in animal models. Dental cavity vaccines directed to key components...
COVID-19 vaccines such as Florida surgeon general Joseph Ladapo have claimed that trace amounts of contaminant DNA present alongside the vaccine's mRNA could...
but possibly less effective approaches such as glycoprotein- and DNA-based vaccines. Due to the current stigma of the Herpes Simplex Virus, the topic...
adjuvant is a substance that increases or modulates the immune response to a vaccine. The word "adjuvant" comes from the Latin word adiuvare, meaning to help...
Malaria vaccines are vaccines that prevent malaria, a mosquito-borne infectious disease which annually affects an estimated 247 million people worldwide...
produced a preclinical DNA-based vaccine as a potential therapy for COVID-19. Inovio is in competition to develop a coronavirus vaccine with numerous other...
for vaccines. Even though there are about 24 traditionally used vaccines, there is still demand for more vaccines. The breakthrough of DNA-vaccines has...
the vaccine is Hantavax. As of 2019 no hantavirus vaccine have been approved for use in Europe or USA. A phase 2 study on a human HTNV/PUUV DNA hantavirus...
article NIAID DNAVaccine for H5N1 Avian Influenza Enters Human Trial published January 2, 2007 "The first human trial of a DNAvaccine designed to prevent...
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