Methocarbamol, sold under the brand name Robaxin among others, is a medication used for short-term musculoskeletal pain.[3][4] It may be used together with rest, physical therapy, and pain medication.[3][5][6] It is less preferred in low back pain.[3] It has limited use for rheumatoid arthritis and cerebral palsy.[3][7] Effects generally begin within half an hour.[3] It is taken by mouth or injection into a vein.[3]
Common side effect include headaches, sleepiness, and dizziness.[3][8] Serious side effects may include anaphylaxis, liver problems, confusion, and seizures.[4] Use is not recommended in pregnancy and breastfeeding.[3][4] Because of risk of injury, skeletal muscle relaxants should generally be avoided in geriatric patients.[3] Methocarbamol is a centrally acting muscle relaxant.[3] How it works is unclear, but it does not appear to affect muscles directly.[3]
Methocarbamol was developed in 1956 in the laboratories of A. H. Robins (later acquired by Pfizer). Studies were directed towards the development of propanediol derivatives which possessed muscle relaxant properties superior to those of mephenesin, which had low potency and a short duration of action.[9] It was approved for medical use in the United States in 1957.[3] It is available as a generic medication.[3][4] It is relatively inexpensive as of 2016.[10] In 2021, it was the 123rd most commonly prescribed medication in the United States, with more than 4million prescriptions.[11][12]
^"Robaxin-750 - Summary of Product Characteristics (SmPC)". (emc). 8 August 2017. Retrieved 19 April 2020.
^Sica DA, Comstock TJ, Davis J, Manning L, Powell R, Melikian A, et al. (1990). "Pharmacokinetics and protein binding of methocarbamol in renal insufficiency and normals". European Journal of Clinical Pharmacology. 39 (2): 193–194. doi:10.1007/BF00280060. PMID 2253675. S2CID 626920.
^ abcdefghijklm"Methocarbamol Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists.
^ abcdBritish national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 1093. ISBN 9780857113382.
^"Robaxin- methocarbamol tablet, film coated". DailyMed. 18 July 2019. Retrieved 19 April 2020.
^"Robaxin- methocarbamol injection". DailyMed. 10 December 2018. Retrieved 19 April 2020.
^Richards BL, Whittle SL, Buchbinder R (January 2012). "Muscle relaxants for pain management in rheumatoid arthritis". The Cochrane Database of Systematic Reviews. 1: CD008922. doi:10.1002/14651858.CD008922.pub2. PMID 22258993. S2CID 73769165.
^"Methocarbamol". LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. National Institute of Diabetes and Digestive and Kidney Diseases. 30 January 2017. PMID 31643609.
^Analytical Profiles of Drug Substances and Excipients, pp. 373
^Cite error: The named reference Ox2016 was invoked but never defined (see the help page).
^"The Top 300 of 2021". ClinCalc. Archived from the original on 15 January 2024. Retrieved 14 January 2024.
^"Methocarbamol - Drug Usage Statistics". ClinCalc. Retrieved 14 January 2024.
Methocarbamol, sold under the brand name Robaxin among others, is a medication used for short-term musculoskeletal pain. It may be used together with...
other countries. Its use has largely been replaced by the related drug methocarbamol, which is better absorbed. Mephenesin may be an NMDA receptor antagonist...
relative), diazepam, tetrazepam and other benzodiazepines, mephenoxalone, methocarbamol, dantrolene, baclofen. Drugs once but no longer or very rarely used...
metabolites. Effectiveness has not been clearly shown for metaxalone, methocarbamol, chlorzoxazone, baclofen, or dantrolene. Applicable conditions include...
(prodrugs of meprobamate), phenprobamate, felbamate, mebutamate, and methocarbamol. Meprobamate is licensed[where?] for the short-term relief of anxiety...
discourages its use as an ingredient in nipple cream for nursing mothers. Methocarbamol Okuyama S, Aihara H (February 1987). "Antinociceptive effect of chlorphenesin...
and include such products as amoxicillin, cephalexin, doxycycline, methocarbamol, and prednisone. Pharmaceutical industry in the United Kingdom "Preliminary...
pharmacokinetics of methocarbamol and guaifenesin after single intravenous and multiple-dose oral administration of methocarbamol in the horse. J. vet...
the concomitant use of the related drug tolperisone hydrochloride and methocarbamol. Seizures have been reported in an infant after accidental ingestion...
inflammation and pain methimazole – used in treatment of hyperthyroidism methocarbamol - muscle relaxant used to reduce muscle spasms associated with inflammation...
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