Delorazepam, also known as chlordesmethyldiazepam and nordiclazepam, is a drug which is a benzodiazepine and a derivative of desmethyldiazepam.[2] It is marketed in Italy, where it is available under the trade name EN and Dadumir.[3] Delorazepam (chlordesmethyldiazepam) is also an active metabolite of the benzodiazepine drugs diclazepam and cloxazolam.[4] Adverse effects may include hangover type effects, drowsiness, behavioural impairments[5][6] and short-term memory impairments.[7] Similar to other benzodiazepines delorazepam has anxiolytic,[8] skeletal muscle relaxant,[9] hypnotic[5] and anticonvulsant properties.[10]
^Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16.
^Govoni S, Fresia P, Spano PF, Trabucchi M (November 1976). "Effect of desmethyldiazepam and chlordesmethyldiazepam on 3',5'-cyclic guanosine monophosphate levels in rat cerebellum". Psychopharmacology. 50 (3): 241–4. doi:10.1007/BF00426839. PMID 188062. S2CID 32711086.
^"Benzodiazepine Names". non-benzodiazepines.org.uk. Archived from the original on 2008-12-08. Retrieved 2008-12-29.
^Oliveira-Silva D, Oliveira CH, Mendes GD, Galvinas PA, Barrientos-Astigarraga RE, De Nucci G (December 2009). "Quantification of chlordesmethyldiazepam by liquid chromatography-tandem mass spectrometry: application to a cloxazolam bioequivalence study". Biomedical Chromatography. 23 (12): 1266–75. doi:10.1002/bmc.1249. PMID 19488979.
^ abZimmermann-Tansella C, Tansella M, Lader M (October 1976). "The effects of chlordesmethyldiazepam on behavioral performance and subjective judgment in normal subjects". Journal of Clinical Pharmacology. 16 (10 Pt 1): 481–88. PMID 977791.
^Cesco G, Giannico S, Fabbruci I, Scaggiante L, Montanaro N (1977). "Single-blind evaluation of hypnotic activity of chlordesmethyldiazepam in No-placebo-reactor medical patients". Arzneimittel-Forschung. 27 (1): 146–8. PMID 322671.
^Scarone S, Strambi LF, Cazzullo CL (1981). "Effects of two dosages of chlordesmethyldiazepam on mnestic-information processes in normal subjects". Clinical Therapeutics. 4 (3): 184–91. PMID 6796270.
^Andreoli V, Maffei F, Montanaro N, Morandini G (February 1977). "Double-blind cross-over clinical comparison of two 2'-chloro benzodiazepines: 7-chloro-5-(2-chlorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one (chlordesmethyldiazepam) versus 7-chloro-5-(o-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one (lorazepam) in neurotic anxiety". Arzneimittel-Forschung. 27 (2): 436–9. PMID 16622.
^Kostowski W, Płaźnik A, Puciłowski O, Trzaskowska E, Lipińska T (1981). "Some behavioral effects of chlorodesmethyldiazepam and lorazepam". Polish Journal of Pharmacology and Pharmacy. 33 (6): 597–602. PMID 6127668.
^Curatolo P, Cusmai R, Trasatti G, Sciarretta A (1985). "[Effects of intravenous administration of chlordesmethyldiazepam on paroxysmal intercritical activity in various electroclinical forms of infantile epilepsy]". Rivista di Neurologia. 55 (6): 377–86. PMID 3938567.
Delorazepam, also known as chlordesmethyldiazepam and nordiclazepam, is a drug which is a benzodiazepine and a derivative of desmethyldiazepam. It is...
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