Leptin receptor, also known as LEP-R or OB-R, is a type I cytokine receptor,[5] a protein that in humans is encoded by the LEPR gene.[6][7] LEP-R functions as a receptor for the fat cell-specific hormone leptin. LEP-R has also been designated as CD295 (cluster of differentiation 295). Its location is the cell membrane, and it has extracellular, trans-membrane and intracellular sections (protein regions).
^ abcGRCh38: Ensembl release 89: ENSG00000116678 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000057722 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Cirillo D, Rachiglio AM, la Montagna R, Giordano A, Normanno N (November 2008). "Leptin signaling in breast cancer: an overview". Journal of Cellular Biochemistry. 105 (4): 956–64. doi:10.1002/jcb.21911. PMID 18821585. S2CID 25572220.
^Tartaglia LA, Dembski M, Weng X, Deng N, Culpepper J, Devos R, et al. (December 1995). "Identification and expression cloning of a leptin receptor, OB-R". Cell. 83 (7): 1263–71. doi:10.1016/0092-8674(95)90151-5. PMID 8548812.
^Winick JD, Stoffel M, Friedman JM (August 1996). "Identification of microsatellite markers linked to the human leptin receptor gene on chromosome 1". Genomics. 36 (1): 221–2. doi:10.1006/geno.1996.0455. PMID 8812446.
Leptinreceptor, also known as LEP-R or OB-R, is a type I cytokine receptor, a protein that in humans is encoded by the LEPR gene. LEP-R functions as...
Teleost leptins are a family of peptide hormones found in fish (teleostei) that are orthologs of the mammalian hormone leptin. The teleost and mammalian...
co-discovery at Rockefeller University of the hormone leptin, and cloning of the leptin and leptinreceptor genes, has had a major role in the area of understanding...
peptide receptor is a type of receptor which binds one or more signaling peptides or signaling proteins. An example is the tropomyosin receptor kinase...
traced to defects in hypothalamic signaling (such as the leptinreceptor and the MC-4 receptor) or are still awaiting characterization – Prader-Willi syndrome –...
carry a mutated ob receptor. Others have been identified as genetically partially deficient in leptin, and, in these individuals, leptin levels on the low...
As a scientist, he is known for first identifying and cloning the leptinreceptor in 1995, a discovery that prompted immediate coverage in US national...
"22nd-century fugu"), has been genetically modified by removing four leptinreceptor genes that control appetite. The result has increased appetite and...
rat (ZDF rat), which is actually a recessive trait (fa/fa) of the leptinreceptor, capable of weighing up to 1 kilogram (2.2 lb) — more than twice the...
the brand name Myalept among others, is a synthetic analog of the hormone leptin used to treat various forms of dyslipidemia. It has been approved in Japan...
Mutations in genes such as LIN28, and LEP and LEPR, which encode leptin and the leptinreceptor, have been associated with precocious puberty. The association...
concentrated source of both leptin and GnRH receptors in the brain. While GnRH receptors in the hypothalamus do not contain receptors for leptin, a positive correlation...
concentrations in plasma; insensitivity or resistance to insulin; mutation of leptinreceptor; and an increase in NPY mRNA and NPY release. In obesity chronically...
nutrient sensing, whereas other receptors (e.g. insulin receptors, leptinreceptors) are extensively multifunctional and perform many functions besides...
Hilary; Ghilardi, Nico; Skoda, Radek C.; Meister, Björn (1998-01-01). "LeptinReceptor Immunoreactivity in Chemically Defined Target Neurons of the Hypothalamus"...
cannabinoids. The sweet receptor (Tlc1) is stimulated by indirectly increasing its expression and suppressing the activity of leptin, the Tlc1 antagonist...
Findlay PA, Hoggard N, Adam CL (September 1998). "Association of leptinreceptor (OB-Rb), NPY and GLP-1 gene expression in the ovine and murine brainstem"...
S, Sayharman S, Kiliç D, Köse G, Küçüközkan T (August 2006). "Leptin and leptinreceptor levels in pregnant women with hyperemesis gravidarum". The Australian...
estradiol secretion. Leptin has key roles in maintaining age appropriate body composition and desired weight. Leptinreceptors are also found in mammary...
Leibel, MD, professor at Columbia University and discoverer of leptin and leptinreceptor Alice H. Lichtenstein, senior scientist and director of Cardiovascular...
a possible mechanism by which amylin treatment could interact with VMH leptin signaling to increase its effect on weight loss. It is assumed that interleukin...
pancreatic polypeptide receptor 1". Al-hussaniy HA, AL-Biati HA (2022-12-02). "The Role of Leptin Hormone, Neuropeptide Y, Ghrelin and Leptin/Ghrelin ratio in...
Orexin-producing cells have been shown to be inhibited by leptin (through the leptinreceptor pathway), but are activated by ghrelin and hypoglycemia (glucose...
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