G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
regulation of blood pressure
central nervous system neuron development
feeding behavior
cerebral cortex development
regulation of appetite
cell population proliferation
innate immune response
neuropeptide signaling pathway
neuron projection development
calcium ion transport
chemical synaptic transmission
antimicrobial humoral immune response mediated by antimicrobial peptide
regulation of signaling receptor activity
G protein-coupled receptor signaling pathway
intestinal epithelial cell differentiation
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
4852
109648
Ensembl
ENSG00000122585
ENSMUSG00000029819
UniProt
P01303
P57774
RefSeq (mRNA)
NM_000905
NM_023456
RefSeq (protein)
NP_000896
NP_075945
Location (UCSC)
Chr 7: 24.28 – 24.29 Mb
Chr 6: 49.8 – 49.81 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Neuropeptide Y
Identifiers
CAS Number
82785-45-3N
ChemSpider
none
UNII
BY7U39XXK0
ChEMBL
ChEMBL267633N
CompTox Dashboard (EPA)
DTXSID4037164
Chemical and physical data
Formula
C190H287N55O57
Molar mass
4253.714 g·mol−1
NY (what is this?)(verify)
Neuropeptide Y (NPY) is a 36 amino-acid neuropeptide that is involved in various physiological and homeostatic processes in both the central and peripheral nervous systems. It is secreted alongside other neurotransmitters such as GABA and glutamate.[5][6][7][8]
In the autonomic system it is produced mainly by neurons of the sympathetic nervous system and serves as a strong vasoconstrictor and also causes growth of fat tissue.[9] In the brain, it is produced in various locations including the hypothalamus, and is thought to have several functions, including: increasing food intake and storage of energy as fat, reducing anxiety and stress, reducing pain perception, affecting the circadian rhythm, reducing voluntary alcohol intake, lowering blood pressure, and controlling epileptic seizures.[8][10]
^ abcGRCh38: Ensembl release 89: ENSG00000122585 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000029819 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Heilig M, Widerlöv E (1995). "Neurobiology and clinical aspects of neuropeptide Y". Critical Reviews in Neurobiology. 9 (2–3): 115–136. PMID 8581979.
^Decressac M, Barker RA (December 2012). "Neuropeptide Y and its role in CNS disease and repair". Experimental Neurology. 238 (2): 265–272. doi:10.1016/j.expneurol.2012.09.004. PMID 23022456. S2CID 15088613.
^Robinson SL, Thiele TE (2017). "The Role of Neuropeptide y (NPY) in Alcohol and Drug Abuse Disorders". The Role of Neuropeptides in Addiction and Disorders of Excessive Consumption. International Review of Neurobiology. Vol. 136. pp. 177–197. doi:10.1016/bs.irn.2017.06.005. ISBN 9780128124734. PMID 29056151.
^ abTatemoto K (2004). "Neuropeptide Y and Related Peptides". In Michel MC (ed.). Neuropeptide Y: History and Overview. Handbook of Experimental Pharmacology. Vol. 162. Springer. pp. 2–15. ISBN 9783540405818.
^Kuo LE, Kitlinska JB, Tilan JU, Li L, Baker SB, Johnson MD, et al. (July 2007). "Neuropeptide Y acts directly in the periphery on fat tissue and mediates stress-induced obesity and metabolic syndrome". Nature Medicine. 13 (7): 803–811. doi:10.1038/nm1611. PMID 17603492. S2CID 25675166.
^Colmers WF, El Bahh B (March 2003). "Neuropeptide Y and Epilepsy". Epilepsy Currents. 3 (2): 53–58. doi:10.1046/j.1535-7597.2003.03208.x. PMC 321170. PMID 15309085.
NeuropeptideY (NPY) is a 36 amino-acid neuropeptide that is involved in various physiological and homeostatic processes in both the central and peripheral...
Neuropeptides are chemical messengers made up of small chains of amino acids that are synthesized and released by neurons. Neuropeptides typically bind...
NeuropeptideY receptors are a family of receptors belonging to class A G-protein coupled receptors and they are activated by the closely related peptide...
NeuropeptideY receptor type 1 is a protein that in humans is encoded by the NPY1R gene. NeuropeptideY (endogenous agonist, non subtype selective) Peptide...
NeuropeptideY receptor type 2 (Y2R) is a member of the neuropeptideY receptor family of G-protein coupled receptors, that in humans is encoded by the...
been. NeuropeptideY receptors have a great concentration in the amygdala, which is involved in the modulation of fear. Research where NeuropeptideY was...
precursors in the mouse subventricular zone through injection of the neuropeptideY (NPY). NPY is a commonly expressed protein of the central nervous system...
of serotonin is the amino acid tryptophan. Peptide transmitters, or neuropeptides, are protein transmitters that often are released together with other...
NeuropeptideY receptor type 5 is a protein that in humans is encoded by the NPY5R gene. NeuropeptideY (endogenous agonist, non subtype selective) BWX-46...
Putative neuropeptideY receptor type 6 is a protein that in humans is encoded by the NPY6R gene. GRCh38: Ensembl release 89: ENSG00000226306 – Ensembl...
also known as NeuropeptideY receptor type 4, is a protein that in humans is encoded by the PPYR1 gene. Pancreatic polypeptide NeuropeptideY (endogenous...
hypothalamus, leptin inhibits hunger by counteracting the effects of neuropeptideY, a potent hunger promoter secreted by cells in the gut and in the hypothalamus...
neurons also integrate information from the body through hormones like neuropeptideY and adiponectin. These hormones provide the GnRH neurons with information...
inhibition. Out of the viral approaches, neuropeptide transgenes being researched are somatostatin, galanin, and neuropeptideY (NPY). However, adenosine and gamma-aminobutyric...
various types or combinations of neurotransmitters and neuropeptides, such as neuropeptideY (NPY), gonadotropin-releasing hormone (GnRH), agouti-related...
arousal. Ultradian rhythms of appetite require antiphasic release of neuropeptideY (NPY) and corticotropin-releasing hormone (CRH), stimulating and inhibiting...
hydroxylase, somatostatin, nitric oxide synthase and neuropeptide-y. Recently, two types of neuropeptide-y expressing GABAergic interneurons have been described...
neurones are important regulators of stress responses. Inputs from neuropeptideY-containing neurons in the arcuate nucleus coordinate metabolic regulation...
enkephalin, phospholipase, and neuropeptideY. Enkephalin and phospholipase both produce inflammatory responses and neuropeptideY induces a severe drop in...
Al-hussaniy, Hany A.; AL-Biati, Haedar A (2022). "The Role of Leptin Hormone, NeuropeptideY, Ghrelin and Leptin/Ghrelin ratio in Obesogenesis". Medical and Pharmaceutical...
Orexin (/ɒˈrɛksɪn/), also known as hypocretin, is a neuropeptide that regulates arousal, wakefulness, and appetite. It exists in the forms of orexin-A...
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