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Nutrient sensing information


Nutrient sensing is a cell's ability to recognize and respond to fuel substrates such as glucose. Each type of fuel used by the cell requires an alternate pathway of utilization and accessory molecules such as enzymes and cofactors. In order to conserve resources a cell will only produce molecules that it needs at the time. The level and type of fuel that is available to a cell will determine the type of enzymes it needs to express from its genome for utilization. Receptors on the cell membrane's surface designed to be activated in the presence of specific fuel molecules communicate to the cell nucleus via a means of cascading interactions. Nutrient receptors are receptors that are primarily designed to perform the function of nutrient sensing, whereas other receptors (e.g. insulin receptors, leptin receptors) are extensively multifunctional and perform many functions besides nutrient sensing.[1] In this way the cell is aware of the available nutrients and is able to produce only the molecules specific to that nutrient type.

  1. ^ A. Nguyen, C.; Akiba, Y.; D. Kaunitz, J. (1 January 2012). "Recent Advances in Gut Nutrient Chemosensing". Current Medicinal Chemistry. 19 (1): 28–34. doi:10.2174/092986712803414033. PMC 4845632.

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Nutrient sensing

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Nutrient sensing is a cell's ability to recognize and respond to fuel substrates such as glucose. Each type of fuel used by the cell requires an alternate...

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Hallmarks of aging

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proteostasis Antagonistic hallmarks (responses to damage) Deregulated nutrient sensing Mitochondrial dysfunction Cellular senescence Integrative hallmarks...

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Nutrition

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Organisms are able to detect nutrients through taste or other forms of nutrient sensing, allowing them to regulate nutrient intake. Optimal foraging theory...

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Neuropod cell

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sensation of nutrients and the regulation of postprandial physiology are enteroendocrine cells. These cells are not only able to assess nutrient content of...

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G1 phase

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Cell Cycle Progression: Distinguishing the Restriction Point from a Nutrient-Sensing Cell Growth Checkpoint(s)". Genes & Cancer. 1 (11): 1124–31. doi:10...

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Nutrient cycle

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A nutrient cycle (or ecological recycling) is the movement and exchange of inorganic and organic matter back into the production of matter. Energy flow...

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Linnaeus University

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Bioorganic and Biophysical Chemistry Laboratory (Prof. Ian A. Nicholls) Nutrient sensing and phosphate transport in ''Saccharomyces cerevisiae''. Biochemistry...

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Nutrient management

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Nutrient management is the science and practice directed to link soil, crop, weather, and hydrologic factors with cultural, irrigation, and soil and water...

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Autophagosome

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complex called Atg13:Atg1, which receives signals from the master of nutrient sensing – Tor. Atg1 is also important in late stages of autophagosome formation...

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Senescence

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attrition, epigenetic alterations, loss of proteostasis, deregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion...

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Eutrophication

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Eutrophication is a general term describing a process in which nutrients accumulate in a body of water, resulting in an increased growth of microorganisms...

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Outline of life extension

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Altered intercellular communication Cellular senescence Deregulated nutrient sensing Epigenetic alterations Genomic instability Loss of proteostasis Mitochondrial...

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Ageing

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loss of proteostasis (protein folding and proteolysis) deregulated nutrient sensing (relating to the Growth hormone/Insulin-like growth factor 1 signalling...

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Pennington Biomedical Research Center

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Neurodegeneration, Nutritional Neuroscience and Aging Nutrient Sensing & Signaling: Nutrient Sensing and Adipocyte Signaling Obesity: Behavior Modification...

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Quorum sensing

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a similar fashion, some social insects use quorum sensing to determine where to nest. Quorum sensing in pathogenic bacteria activates host immune signaling...

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Leptin

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PMID 17339026. Obici S, Rossetti L (December 2003). "Minireview: nutrient sensing and the regulation of insulin action and energy balance". Endocrinology...

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Intron

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starvation via intron enhanced repression of ribosomal protein genes of nutrient-sensing pathways. Introns may be lost or gained over evolutionary time, as...

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Shaodong Guo

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Taken together, Guo's research projects highlight the importance of nutrient sensing and hormonal signaling in the regulation of gene transcription via...

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Soil

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air, water, temperature moderation, nutrients, and protection from toxins. Soils provide readily available nutrients to plants and animals by converting...

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Diabetic nephropathy

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PMID 26676664. Kume S, Koya D, Uzu T, Maegawa H (2014). "Role of nutrient-sensing signals in the pathogenesis of diabetic nephropathy". BioMed Research...

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Life extension

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attrition, epigenetic alterations, loss of proteostasis, deregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion...

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Mangrove

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Gebhardt, S.; Vo Quoc, T. & Dech, S. (2011). "Remote Sensing of Mangrove Ecosystems: A Review". Remote Sensing. 3 (5): 878–928. Bibcode:2011RemS....3..878K....

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Johan Thevelein

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research interest is on the molecular genetics and biochemistry of nutrient-sensing and -signaling in Saccharomyces cerevisiae (yeast). "VIB and Performa...

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Stuart Schreiber

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investigated (independently with David Sabitini) the master regulator of nutrient sensing, mTOR. They found that the small molecule rapamycin simultaneously...

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DNA repair

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results in extended lifespan in a variety of organisms, likely via nutrient sensing pathways and decreased metabolic rate. The molecular mechanisms by...

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Bioluminescent bacteria

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The evolution of quorum sensing is believed to have afforded further selective advantage for light production. Quorum sensing allows bacteria to conserve...

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