Monogenic obesity is excess weight caused by a mutation in a single gene, as opposed to syndromic obesity not tied to a single gene variation and most obesity, which is caused by multiple genetic and environmental risk factors. Monogenetic obesity mostly affects the hypothalamus and leptin–melanocortin system (see hypothalamic obesity). However, it accounts for less than 5 percent of severe obesity cases. Known mutations leading to monogenetic obesity include:[1]
Leptin deficiency
Leptin receptor deficiency
Melanocortin-4 receptor (MC4R)
Proopiomelanocortin (POMC
Prohormone convertase 1/3 (PC1/3)
SIM1
BDNF
NTRK2
^Ranadive, Sayali A.; Vaisse, Christian (September 2008). "Lessons from Extreme Human Obesity: Monogenic Disorders". Endocrinology and Metabolism Clinics of North America. 37 (3): 733–751. doi:10.1016/j.ecl.2008.07.003. ISSN 0889-8529. PMC 5877402. PMID 18775361.
Monogenicobesity is excess weight caused by a mutation in a single gene, as opposed to syndromic obesity not tied to a single gene variation and most...
Monogenic obesityMonogenic field, in mathematics, an algebraic number field K Monogenic function, a function in an algebra over a field Monogenic polynomial...
velocity (MC4R monogenic diabetes).[citation needed] There is limited treatment options for the most common form of monogenicobesity, MC4R mutations...
the hypothalamus (see hypothalamic obesity). Known types of syndromic obesity include some types of monogenicobesity and: Prader Willi syndrome Bardet-Biedl...
thus rendering obsolete the distinction between rare monogenicobesity and common polygenic obesity. Garfield, AS; Lam, DD; Marston, OJ; Przydzial, MJ;...
abnormalities in the genome. It can be caused by a mutation in a single gene (monogenic) or multiple genes (polygenic) or by a chromosomal abnormality. Although...
antiobesity drug being tested in people with Prader-Willi syndrome and monogenicobesity caused by mutations in the SH2B1, PCSK1, or SIM1 genes. "Product monograph...
and obesity, other factors are not, such as increasing age, female sex, and genetics.Generous consumption of alcohol is also a risk factor. Obesity is...
Alcohol-associated liver disease (ALD) Specific aetiology SLD (including drug-induced, monogenic diseases and others) Often there are no or few symptoms. Occasionally...
the obese state, either now or in the past. The main feature of this hypothesis is that the current pattern of obesity does not suggest that obesity has...
lipodystrophy, also known as FPLD Type II and abbreviated as (FPLD2), is a rare monogenic form of insulin resistance characterized by loss of subcutaneous fat from...
people with obesity without AF and may reduce the risk of a recurrence of AF after an ablation procedure in people with coexisting obesity and atrial fibrillation...
(UK). Archived from the original on 2021-08-28. Retrieved 2018-08-21. "Monogenic Forms of Diabetes". National institute of diabetes and digestive and kidney...
than the human body can handle. On the opposite end, endogenous obesity refers to obesity caused by disorders or issues outside an imbalance of food intake...
previously undescribed genetic obesity syndromes, and establishing that the principal driver of obesity in these monogenic syndromes was a failure of the...
as its body mass or skin color.[citation needed] Apart from the true monogenic genetic disorders, environmental factors may determine the development...
PMC 6005224. PMID 29415907. Boman H, Hazzard WR, AlbersJJ, et ah Frequency of monogenic forms of hyperlipidemia in a normal population. AmJ ttum Genet 27:19A...
incidence of some monogenic diseases, and they may contribute to differences in the incidence of some common diseases. For the monogenic diseases, the frequency...
or protein. This therapy has been found especially useful in treating monogenic disease (e.g. cystic fibrosis, X-linked SCID, alpha1-antitrypsin deficiency)...
YX (2016). "Ghrelin Receptor Mutations and Human Obesity". Genetics of Monogenic and Syndromic Obesity. Vol. 140. pp. 131–50. doi:10.1016/bs.pmbts.2016...
diabetes that arise due to an abnormality in a single gene (known as monogenic forms of diabetes). These include maturity onset diabetes of the young...
high blood pressure; ten genes have been identified which cause these monogenic forms of hypertension. These mutations affect blood pressure by altering...
causes a number of different autoinflammatory syndromes, most notably the monogenic conditions referred to as Cryopyrin-Associated Periodic Syndromes (CAPS)...
it is important to realize that polygenic traits are different from monogenic traits; the latter stem from fewer genetic loci and can be detected more...
JM, Hatziagelaki E, Kolaitis G (2015). "Brain "fog," inflammation and obesity: key aspects of neuropsychiatric disorders improved by luteolin". Frontiers...
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