endoplasmic reticulum to Golgi vesicle-mediated transport
epithelial cell proliferation involved in mammary gland duct elongation
COPII vesicle coating
glial cell proliferation
response to cAMP
positive regulation of phosphorylation
cell population proliferation
neuron projection development
response to hydrogen peroxide
positive regulation of peptidyl-tyrosine phosphorylation
regulation of signaling receptor activity
positive regulation of cell population proliferation
MAPK cascade
signal transduction
negative regulation of epidermal growth factor receptor signaling pathway
positive regulation of protein kinase B signaling
membrane organization
positive regulation of keratinocyte proliferation
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
374
11839
Ensembl
ENSG00000109321
ENSMUSG00000029378
UniProt
P15514
P31955
RefSeq (mRNA)
NM_001657
NM_009704
RefSeq (protein)
NP_001648
NP_033834
Location (UCSC)
Chr 4: 74.45 – 74.46 Mb
Chr 5: 91.29 – 91.3 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Amphiregulin, also known as AREG, is a protein synthesized as a transmembrane glycoprotein with 252 aminoacids and it is encoded by the AREG gene.[5][6][7] in humans.[8]
^ abcGRCh38: Ensembl release 89: ENSG00000109321 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000029378 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Shoyab M, Plowman GD, McDonald VL, Bradley JG, Todaro GJ (February 1989). "Structure and function of human amphiregulin: a member of the epidermal growth factor family". Science. 243 (4894 Pt 1): 1074–1076. Bibcode:1989Sci...243.1074S. doi:10.1126/science.2466334. PMID 2466334.
^Plowman GD, Green JM, McDonald VL, Neubauer MG, Disteche CM, Todaro GJ, et al. (May 1990). "The amphiregulin gene encodes a novel epidermal growth factor-related protein with tumor-inhibitory activity". Molecular and Cellular Biology. 10 (5): 1969–1981. doi:10.1128/MCB.10.5.1969. PMC 360543. PMID 2325643.
^"AREG (amphiregulin (schwannoma-derived growth factor))". atlasgeneticsoncology.org. Archived from the original on 2019-08-27. Retrieved 2019-08-27.
Amphiregulin, also known as AREG, is a protein synthesized as a transmembrane glycoprotein with 252 aminoacids and it is encoded by the AREG gene. in humans...
prolactin. These regulators induce the expression of growth factors, such as amphiregulin, epidermal growth factor (EGF), IGF-1, and fibroblast growth factor (FGF)...
development of the mammary glands, and agonists of the EGFR such as amphiregulin, TGF-α, and heregulin induce both ductal and lobuloalveolar development...
mediates ductal development mainly via induction of the expression of amphiregulin, the same growth factor that estrogen primarily induces the expression...
COOH-terminal region of the epidermal growth factor (EGF) receptor in amphiregulin and EGF mitogenic signaling". The Journal of Biological Chemistry. 274...
help pulmonary wound healing after influenza infection by secreting amphiregulin. Besides lungs, ILC2 populations can also be found in human nasal and...
Global Information
