Series of events that restore integrity to damaged tissue after an injury
Hand abrasion
Initial injury
3 days
17 days
30 days
Wound healing refers to a living organism's replacement of destroyed or damaged tissue by newly produced tissue.[1]
In undamaged skin, the epidermis (surface, epithelial layer) and dermis (deeper, connective layer) form a protective barrier against the external environment. When the barrier is broken, a regulated sequence of biochemical events is set into motion to repair the damage.[1][2] This process is divided into predictable phases: blood clotting (hemostasis), inflammation, tissue growth (cell proliferation), and tissue remodeling (maturation and cell differentiation). Blood clotting may be considered to be part of the inflammation stage instead of a separate stage.[3]
Deep wound on shin with stitches healing over five weeks
The wound-healing process is not only complex but fragile, and it is susceptible to interruption or failure leading to the formation of non-healing chronic wounds. Factors that contribute to non-healing chronic wounds are diabetes, venous or arterial disease, infection, and metabolic deficiencies of old age.[4]
Wound care encourages and speeds wound healing via cleaning and protection from reinjury or infection. Depending on each patient's needs, it can range from the simplest first aid to entire nursing specialties such as wound, ostomy, and continence nursing and burn center care.
^ abNguyen DT, Orgill DP, Murphy GT (2009). "4 The Pathophysiologic Basis for Wound Healing and Cutaneous Regeneration". In Orgill DP, Blanco C (eds.). Biomaterials for Treating Skin Loss. Elsevier. pp. 25–57. ISBN 978-1-84569-554-5.
^Rieger S, Zhao H, Martin P, Abe K, Lisse TS (January 2015). "The role of nuclear hormone receptors in cutaneous wound repair". Cell Biochemistry and Function. 33 (1): 1–13. doi:10.1002/cbf.3086. PMC 4357276. PMID 25529612.
^Stadelmann WK, Digenis AG, Tobin GR (August 1998). "Physiology and healing dynamics of chronic cutaneous wounds". American Journal of Surgery. 176 (2A Suppl): 26S–38S. doi:10.1016/S0002-9610(98)00183-4. PMID 9777970.
^Enoch, S. Price, P. (2004). Cellular, molecular and biochemical differences in the pathophysiology of healing between acute wounds, chronic wounds and wounds in the elderly Archived 2017-07-06 at the Wayback Machine.
The wound-healing process is not only complex but fragile, and it is susceptible to interruption or failure leading to the formation of non-healing chronic...
stages of woundhealing. Both wound types can further be categorized by cause of injury, wound severity/depth, and sterility of the wound bed. Several...
Franz, said “the woundedhealer IS the archetype of the Self [our wholeness, the God within] and is at the bottom of all genuine healing procedures.”[citation...
MG53 and TGF beta 1 play important roles in woundhealing. In response to an incision or wound, a woundhealing cascade is unleashed. This cascade takes...
form very quickly over the burn, helping it to heal rapidly. Throughout the four phases of woundhealing, collagen performs the following functions: Guiding...
chronic wounds are at opposite ends of a spectrum of wound-healing types that progress toward being healed at different rates. Chronic wound patients...
properties that aid woundhealing. Saliva contains cell-derived tissue factor, and many compounds that are antibacterial or promote healing. Salivary tissue...
A woundhealing assay is a laboratory technique used to study cell migration and cell–cell interaction. This is also called a scratch assay because it...
leading to amputation. Woundhealing is an innate mechanism of action that works reliably most of the time. A key feature of woundhealing is stepwise repair...
inflammatory signals and consequently woundhealing process. Moreover, the clotting mechanisms during the first stage of woundhealing may be improved by calcium...
(April 1991). "Studies in fetal woundhealing. V. A prolonged presence of hyaluronic acid characterizes fetal wound fluid". Ann. Surg. 213 (4): 292–6...
effect on woundhealing. Some research finds benefit, while other research find delays and healing inhibition. Its use for home treatment of wounds is generally...
sheep. OFM is used in tissue engineering and as a tissue scaffold for woundhealing and surgical applications OFM was developed and is manufactured by Aroa...
prevention of skin injuries. Skin care is a part of the treatment of woundhealing, radiation therapy and some medications. Skin care is at the interface...
angiogenesis and woundhealing, without causing softening and breaking down of tissue. The gel which is formed as a result of the absorption of wound exudate is...
Myofibroblasts were first identified in granulation tissue during skin woundhealing. Typically, these cells are found in granulation tissue, scar tissue...
learned and passed down after healers repeatedly used an herbal remedy for a specific wound with the belief that it promoted healing. Numerous ancient herbal...
animals; this prompts woundhealing, which may be rapid, as in the Cnidaria. Injuries to animals including humans can be caused by wounding, change in pressure...
woundhealing include the continuous stabilization of doxycycline, scaling up technology and industrial production, and exploring non-contact wound treatment...
forming tonofilaments. Recent attention has been drawn to the remarkable wound-healing capabilities and excellent biocompatibility of keratin derived from...
known as The Healing Foundation, it was relaunched as The Scar Free Foundation in 2016. The charity funds medical research into woundhealing and scarring...
Sholar A. (2006). Woundhealing: Chronic wounds. Emedicine.com. Accessed 20 January 2008. "The phases of cutaneous woundhealing" (PDF). Expert Reviews...
migration, and differentiation, and it is important for processes such as woundhealing and embryonic development. Altered fibronectin expression, degradation...
There is evidence that maggot therapy may help with woundhealing. Maggot therapy improves healing in chronic ulcers. In diabetic foot ulcers there is...
follicle formation during the healing of large wounds. Functional keratinocytes are needed for tympanic perforation healing. A sunburn cell is a keratinocyte...
of animals; this prompts woundhealing. In both plants and animals, substances are often released to help to occlude the wound, limiting loss of fluids...
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