HNRNPAB information

HNRNPAB
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3S7R
Identifiers
Aliases	HNRNPAB, ABBP1, HNRPAB, heterogeneous nuclear ribonucleoprotein A/B
External IDs	OMIM: 602688; MGI: 1330294; HomoloGene: 74950; GeneCards: HNRNPAB; OMA:HNRNPAB - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	178,211,163 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	51,497,674 bp
RNA expression pattern
	Top expressed in
	mucosa of sigmoid colon; ; embryo; ; ganglionic eminence; ; human penis; ; mucosa of ileum; ; ventricular zone; ; mucosa of transverse colon; ; rectum; ; vulva; ; skin of thigh;
	Top expressed in
	primitive streak; ; abdominal wall; ; medial ganglionic eminence; ; condyle; ; hair follicle; ; vas deferens; ; endothelial cell of lymphatic vessel; ; Rostral migratory stream; ; renal corpuscle; ; Gonadal ridge;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA-binding transcription factor activity; nucleic acid binding; sequence-specific DNA binding; protein binding; mRNA binding; RNA binding; sequence-specific double-stranded DNA binding;
Cellular component	cytoplasm; RNA polymerase II transcription regulator complex; nucleus; nucleoplasm; ribonucleoprotein complex;
Biological process	positive regulation of transcription, DNA-templated; epithelial to mesenchymal transition;
	Sources:Amigo / QuickGO
Orthologs
	3182
	15384
	ENSG00000197451
	ENSMUSG00000020358
	Q99729
	Q99020
	NM_031266; NM_004499
	NM_001048061; NM_010448
	NP_004490; NP_112556
	NP_001041526; NP_034578
	Wikidata
View/Edit Human	View/Edit Mouse

Heterogeneous nuclear ribonucleoprotein A/B, also known as HNRNPAB, is a protein which in humans is encoded by the HNRNPAB gene.^[5] Although this gene is named HNRNPAB in reference to its first cloning as an RNA binding protein with similarity to HNRNP A and HNRNP B,^[6] it is not a member of the HNRNP A/B subfamily of HNRNPs, but groups together closely with HNRNPD/AUF1 and HNRNPDL.^[7]^[8]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000197451 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020358 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "HNRNPAB heterogeneous nuclear ribonucleoprotein A/B [ Homo sapiens (human) ]".
^ Khan FA, Jaiswal AK, Szer W (September 1991). "Cloning and sequence analysis of a human type A/B hnRNP protein". FEBS Letters. 290 (1–2): 159–61. doi:10.1016/0014-5793(91)81249-8. PMID 1717314. S2CID 11348906.
^ Akindahunsi AA, Bandiera A, Manzini G (February 2005). "Vertebrate 2xRBD hnRNP proteins: a comparative analysis of genome, mRNA and protein sequences". Computational Biology and Chemistry. 29 (1): 13–23. doi:10.1016/j.compbiolchem.2004.11.002. PMID 15680582.
^ Czaplinski K, Köcher T, Schelder M, Segref A, Wilm M, Mattaj IW (April 2005). "Identification of 40LoVe, a Xenopus hnRNP D family protein involved in localizing a TGF-beta-related mRNA during oogenesis". Developmental Cell. 8 (4): 505–15. doi:10.1016/j.devcel.2005.01.012. PMID 15809033.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000197451 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020358 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "HNRNPAB heterogeneous nuclear ribonucleoprotein A/B [ Homo sapiens (human) ]".

[pmid1717314-6] Khan FA, Jaiswal AK, Szer W (September 1991). "Cloning and sequence analysis of a human type A/B hnRNP protein". FEBS Letters. 290 (1–2): 159–61. doi:10.1016/0014-5793(91)81249-8. PMID 1717314. S2CID 11348906.

[pmid15680582-7] Akindahunsi AA, Bandiera A, Manzini G (February 2005). "Vertebrate 2xRBD hnRNP proteins: a comparative analysis of genome, mRNA and protein sequences". Computational Biology and Chemistry. 29 (1): 13–23. doi:10.1016/j.compbiolchem.2004.11.002. PMID 15680582.

[pmid15809033-8] Czaplinski K, Köcher T, Schelder M, Segref A, Wilm M, Mattaj IW (April 2005). "Identification of 40LoVe, a Xenopus hnRNP D family protein involved in localizing a TGF-beta-related mRNA during oogenesis". Developmental Cell. 8 (4): 505–15. doi:10.1016/j.devcel.2005.01.012. PMID 15809033.

HNRNPAB information

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