dentate gyrus of hippocampal formation granule cell
hippocampus proper
esophagus
striatum of neuraxis
uterus
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
metal ion binding
protein binding
protein heterodimerization activity
heat shock protein binding
amyloid-beta binding
complement component C3b binding
cargo receptor activity
Cellular component
extracellular exosome
plasma membrane
cell surface
membrane
integral component of membrane
integrin complex
extracellular space
specific granule membrane
tertiary granule membrane
external side of plasma membrane
integrin alphaM-beta2 complex
plasma membrane raft
membrane raft
Biological process
ectodermal cell differentiation
toll-like receptor 4 signaling pathway
integrin-mediated signaling pathway
leukocyte migration
extracellular matrix organization
cell adhesion
neutrophil degranulation
microglial cell activation
immune system process
receptor-mediated endocytosis
phagocytosis, engulfment
cytokine-mediated signaling pathway
positive regulation of superoxide anion generation
positive regulation of neutrophil degranulation
innate immune response
negative regulation of dopamine metabolic process
positive regulation of protein targeting to membrane
amyloid-beta clearance
cell-cell adhesion via plasma-membrane adhesion molecules
complement-mediated synapse pruning
vertebrate eye-specific patterning
positive regulation of neuron death
positive regulation of microglial cell activation
positive regulation of microglial cell mediated cytotoxicity
cell surface receptor signaling pathway involved in cell-cell signaling
positive regulation of prostaglandin-E synthase activity
forebrain development
apoptotic signaling pathway
positive regulation of hippocampal neuron apoptotic process
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
3684
16409
Ensembl
ENSG00000169896
ENSMUSG00000030786
UniProt
P11215
P05555
RefSeq (mRNA)
NM_000632 NM_001145808
NM_001082960 NM_008401
RefSeq (protein)
NP_000623 NP_001139280
n/a
Location (UCSC)
Chr 16: 31.26 – 31.33 Mb
Chr 7: 127.66 – 127.72 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Integrin alpha M (ITGAM) is one protein subunit that forms heterodimeric integrin alpha-M beta-2 (αMβ2) molecule, also known as macrophage-1 antigen (Mac-1) or complement receptor 3 (CR3).[5] ITGAM is also known as CR3A, and cluster of differentiation molecule 11B (CD11B). The second chain of αMβ2 is the common integrin β2 subunit known as CD18, and integrin αMβ2 thus belongs to the β2 subfamily (or leukocyte) integrins.[6]
αMβ2 is expressed on the surface of many leukocytes involved in the innate immune system, including monocytes, granulocytes, macrophages, and natural killer cells [5] and subsets of T and B cells.[7] It mediates inflammation by regulating leukocyte adhesion and migration and has been implicated in several immune processes such as phagocytosis, cell-mediated cytotoxicity, chemotaxis and cellular activation.[5] It is involved in the complement system due to its capacity to bind inactivated complement component 3b (iC3b).[8] The ITGAM (alpha) subunit of integrin αMβ2 is directly involved in causing the adhesion and spreading of cells but cannot mediate cellular migration without the presence of the β2 (CD18) subunit.[5]
In genomewide association studies, single nucleotide polymorphisms in ITGAM had the strongest association with systemic lupus erythematosus, with an odds ratio of 1.65 for the T allele of rs9888739 and lupus.[9][10]
In histopathology, immunohistochemistry with antibodies against CD11B is frequently used to identify macrophages and microglia.
^ abcGRCh38: Ensembl release 89: ENSG00000169896 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000030786 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ abcdSolovjov DA, Pluskota E, Plow EF (January 2005). "Distinct roles for the alpha and beta subunits in the functions of integrin alphaMbeta2". The Journal of Biological Chemistry. 280 (2): 1336–1345. doi:10.1074/jbc.M406968200. PMID 15485828.
^Larson RS, Springer TA (April 1990). "Structure and function of leukocyte integrins". Immunological Reviews. 114: 181–217. doi:10.1111/j.1600-065X.1990.tb00565.x. PMID 2196220. S2CID 36709941.
^Khan SQ, Khan I, Gupta V (2018-03-15). "CD11b Activity Modulates Pathogenesis of Lupus Nephritis". Frontiers in Medicine. 5: 52. doi:10.3389/fmed.2018.00052. PMC 5862812. PMID 29600248.
^Arnaout MA, Todd RF, Dana N, Melamed J, Schlossman SF, Colten HR (July 1983). "Inhibition of phagocytosis of complement C3- or immunoglobulin G-coated particles and of C3bi binding by monoclonal antibodies to a monocyte-granulocyte membrane glycoprotein (Mol)". The Journal of Clinical Investigation. 72 (1): 171–179. doi:10.1172/JCI110955. PMC 1129172. PMID 6874946.
^Crow MK (February 2008). "Collaboration, genetic associations, and lupus erythematosus". The New England Journal of Medicine. 358 (9): 956–961. doi:10.1056/NEJMe0800096. PMID 18204099.
^Hom G, Graham RR, Modrek B, Taylor KE, Ortmann W, Garnier S, et al. (February 2008). "Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX". The New England Journal of Medicine. 358 (9): 900–909. doi:10.1056/NEJMoa0707865. PMID 18204098.
IntegrinalphaM (ITGAM) is one protein subunit that forms heterodimeric integrinalpha-M beta-2 (αMβ2) molecule, also known as macrophage-1 antigen (Mac-1)...
Integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide), also known as ITGAL, is a protein that in humans...
is an integrinalpha subunit. It makes up half of the α4β1 lymphocyte homing receptor. The product of this gene belongs to the integrinalpha chain family...
known as Integrin, alpha X (complement component 3 receptor 4 subunit) (ITGAX), is a gene that encodes for CD11c . CD11c is an integrinalpha X chain protein...
Integrins are transmembrane receptors that help cell-cell and cell-extracellular matrix (ECM) adhesion. Upon ligand binding, integrins activate signal...
CD49b gene. The CD49b protein is an integrinalpha subunit. It makes up half of the α2β1 integrin duplex. Integrins are heterodimeric integral membrane...
Integrinalpha-IIb is a protein that in humans is encoded by the ITGA2B gene. ITGA2B, also known as CD41, encodes integrinalpha chain 2b. Integrins are...
Integrinalpha-V is a protein that in humans is encoded by the ITGAV gene. ITGAV encodes integrinalpha chain V. Integrins are heterodimeric integral membrane...
Alpha-7 integrin is a protein that in humans is encoded by the ITGA7 gene. Alpha-7 integrin is critical for modulating cell-matrix interactions. Alpha-7...
Integrinalpha-5 is a protein that in humans is encoded by the ITGA5 gene. The product of this gene belongs to the integrinalpha chain family. Integrins...
CD18 (Integrin beta chain-2) is an integrin beta chain protein that is encoded by the ITGB2 gene in humans. Upon binding with one of a number of alpha chains...
Integrinalpha-6 is a protein that in humans is encoded by the ITGA6 gene. The ITGA6 protein product is the integrinalpha chain alpha 6. Integrins are...
with integrinalpha 1 and integrinalpha 2 to form integrin complexes which function as collagen receptors. It also forms dimers with integrinalpha 3 to...
Integrinalpha-9 is a protein that in humans is encoded by the ITGA9 gene. Cytogenetic location: 3p22.2 This gene encodes an alphaintegrin. Integrins...
Integrinalpha-10 also known as ITGA10 is a protein that in humans is encoded by the ITGA10 gene. Integrins are integral membrane proteins composed of...
Integrinalpha-11 is a protein that, in humans, is encoded by the ITGA11 gene. This gene encodes an alphaintegrin. Integrins are heterodimeric integral...
Integrinalpha-8 is a protein that in humans is encoded by the ITGA8 gene. GRCh38: Ensembl release 89: ENSG00000077943 – Ensembl, May 2017 GRCm38: Ensembl...
ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given...
Integrinalpha-D is a protein that in humans is encoded by the ITGAD gene. GRCh38: Ensembl release 89: ENSG00000156886 – Ensembl, May 2017 GRCm38: Ensembl...
Integrin, beta 4 (ITGB4) also known as CD104 (Cluster of Differentiation 104), is a human gene. Integrins are heterodimers composed of alpha and beta subunits...
survival, and transcription. Integrins are heterodimeric, as they consist of an alpha and beta subunit. There are currently 18 alpha subunits and 8 beta subunits...
Integrin beta-7 is an integrin protein that in humans is encoded by the ITGB7 gene. It can pair with ITGA4 (CD49d) to form the heterodimeric integrin...
Integrin beta-6 is a protein that in humans is encoded by the ITGB6 gene. It is the β6 subunit of the integrin αvβ6. Integrins are αβ heterodimeric glycoproteins...
Ugarova TP, Ye RD, Lau LF, Lam SC (June 2002). "Identification of integrinalpha(M)beta(2) as an adhesion receptor on peripheral blood monocytes for Cyr61...
Integrin, alpha E (ITGAE) also known as CD103 (cluster of differentiation 103) is an integrin protein that in human is encoded by the ITGAE gene. CD103...
Global Information
