positive regulation of protein targeting to mitochondrion
neutrophil degranulation
cytokine-mediated signaling pathway
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
3687
16411
Ensembl
ENSG00000140678
ENSMUSG00000030789
UniProt
P20702
Q9QXH4
RefSeq (mRNA)
NM_000887 NM_001286375
NM_021334 NM_001363984 NM_001363985
RefSeq (protein)
NP_000878 NP_001273304
NP_067309 NP_001350913 NP_001350914
Location (UCSC)
Chr 16: 31.36 – 31.38 Mb
Chr 7: 127.73 – 127.75 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
CD11c, also known as Integrin, alpha X (complement component 3 receptor 4 subunit) (ITGAX), is a gene that encodes for CD11c .[5][6]
CD11c is an integrin alpha X chain protein. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as inactivated-C3b (iC3b) receptor 4 (CR4). The alpha X beta 2 complex seems to overlap the properties of the alpha M beta 2 integrin in the adherence of neutrophils and monocytes to stimulated endothelium cells, and in the phagocytosis of complement coated particles.[5]
CD11c is a type I transmembrane protein found at high levels on most human dendritic cells, but also on monocytes, macrophages, neutrophils, and some B cells that induces cellular activation and helps trigger neutrophil respiratory burst; expressed in hairy cell leukemias, acute nonlymphocytic leukemias, and some B-cell chronic lymphocytic leukemias.
^ abcGRCh38: Ensembl release 89: ENSG00000140678 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000030789 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
known as Integrin, alphaX (complement component 3 receptor 4 subunit) (ITGAX), is a gene that encodes for CD11c . CD11c is an integrinalphaX chain protein...
Integrinalpha M (ITGAM) is one protein subunit that forms heterodimeric integrinalpha-M beta-2 (αMβ2) molecule, also known as macrophage-1 antigen (Mac-1)...
Integrinalpha-IIb is a protein that in humans is encoded by the ITGA2B gene. ITGA2B, also known as CD41, encodes integrinalpha chain 2b. Integrins are...
is an integrinalpha subunit. It makes up half of the α4β1 lymphocyte homing receptor. The product of this gene belongs to the integrinalpha chain family...
Integrins are transmembrane receptors that help cell-cell and cell-extracellular matrix (ECM) adhesion. Upon ligand binding, integrins activate signal...
Integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide), also known as ITGAL, is a protein that in humans...
Alpha-7 integrin is a protein that in humans is encoded by the ITGA7 gene. Alpha-7 integrin is critical for modulating cell-matrix interactions. Alpha-7...
with integrinalpha 1 and integrinalpha 2 to form integrin complexes which function as collagen receptors. It also forms dimers with integrinalpha 3 to...
CD18 (Integrin beta chain-2) is an integrin beta chain protein that is encoded by the ITGB2 gene in humans. Upon binding with one of a number of alpha chains...
Integrinalpha-8 is a protein that in humans is encoded by the ITGA8 gene. GRCh38: Ensembl release 89: ENSG00000077943 – Ensembl, May 2017 GRCm38: Ensembl...
Integrin, beta 4 (ITGB4) also known as CD104 (Cluster of Differentiation 104), is a human gene. Integrins are heterodimers composed of alpha and beta subunits...
Integrin beta-6 is a protein that in humans is encoded by the ITGB6 gene. It is the β6 subunit of the integrin αvβ6. Integrins are αβ heterodimeric glycoproteins...
ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given...
survival, and transcription. Integrins are heterodimeric, as they consist of an alpha and beta subunit. There are currently 18 alpha subunits and 8 beta subunits...
not listed on hcdm Bennett JS. Structure and function of the platelet integrinalphaIIbbeta3. J Clin Invest 2005; 115:3363-9. "FITC Anti-human CD51 Antibody...
Integrin beta-7 is an integrin protein that in humans is encoded by the ITGB7 gene. It can pair with ITGA4 (CD49d) to form the heterodimeric integrin...
Integrin, alpha E (ITGAE) also known as CD103 (cluster of differentiation 103) is an integrin protein that in human is encoded by the ITGAE gene. CD103...
to integrin α4β7 (LPAM-1, lymphocyte Peyer's patch adhesion molecule 1, a dimer of Integrinalpha-4 and Integrin beta-7), blocking the α4β7 integrin results...
(2012). "Alpha V integrins and TGF-beta-induced EMT: a circle of regulation". J Cell Mol Med. 16 (3): 445–55. doi:10.1111/j.1582-4934.2011.01419.x. PMC 3290750...
Kawakatsu H, Griffiths MJ, Dalton SL, Wu J, et al. (February 1999). "The integrinalpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating...
PAK4. ITGB5 encodes a subunit of integrin that can interact with several alpha chains to form a variety of integrin heterodimers. It also plays a potential...
PMID 16877343. Morris DG, Huang X, Kaminski N, Wang Y, Shapiro SD, Dolganov G, Glick A, Sheppard D (March 2003). "Loss of integrinalpha(v)beta6-mediated TGF-beta...
(MAdCAM-1) demonstrates structural and functional similarities to the alpha 4 beta 7-integrin binding domains of murine MAdCAM-1, but extreme divergence of mucin-like...
Global Information
