ITGAE information

ITGAE
Identifiers
Aliases	ITGAE, CD103, HUMINAE, integrin subunit alpha E
External IDs	OMIM: 604682 MGI: 1298377 HomoloGene: 113560 GeneCards: ITGAE
Gene location (Human)
Chr.	Chromosome 17 (human)
End	3,801,188 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	73,038,272 bp
RNA expression pattern
	Top expressed in
	oocyte; ; secondary oocyte; ; biceps brachii; ; putamen; ; triceps brachii muscle; ; caudate nucleus; ; monocyte; ; lymph node; ; nucleus accumbens; ; jejunal mucosa;
	Top expressed in
	seminiferous tubule; ; spermatid; ; spermatocyte; ; Paneth cell; ; blood; ; jejunum; ; thymus; ; duodenum; ; morula; ; substantia nigra;
	More reference expression data
	n/a
Gene ontology
Molecular function	metal ion binding;
Cellular component	integral component of membrane; integrin complex; plasma membrane; external side of plasma membrane; membrane;
Biological process	integrin-mediated signaling pathway; cell adhesion; extracellular matrix organization;
	Sources:Amigo / QuickGO
Orthologs
	3682
	16407
	ENSG00000083457
	ENSMUSG00000005947
	P38570
	Q60677
	NM_002208
	NM_008399; NM_172944; NM_001361245
	NP_002199
	NP_032425; NP_001348174
	Wikidata
View/Edit Human	View/Edit Mouse

Integrin, alpha E (ITGAE) also known as CD103 (cluster of differentiation 103) is an integrin protein that in human is encoded by the ITGAE gene.^[5]^[6] CD103 binds integrin beta 7 (β7– ITGB7) to form the complete heterodimeric integrin molecule αEβ7, which has no distinct name. The αEβ7 complex is often referred to as "CD103" though this strictly refers only to the αE chain. Note that the β7 subunit can bind with other integrin α chains, such as α4 (CD49d).

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000083457 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000005947 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kilshaw PJ, Higgins JM (2002). "Alpha E: no more rejection?". J. Exp. Med. 196 (7): 873–5. doi:10.1084/jem.20021404. PMC 2194032. PMID 12370249.
^ "Entrez Gene: integrin".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000083457 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000005947 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12370249-5] Kilshaw PJ, Higgins JM (2002). "Alpha E: no more rejection?". J. Exp. Med. 196 (7): 873–5. doi:10.1084/jem.20021404. PMC 2194032. PMID 12370249.

[entrez-6] "Entrez Gene: integrin".

ITGAE information

and 5 Related for: ITGAE information

ITGAE

Integrin beta 7

List of distinct cell types in the adult human body

Integrin

Von Willebrand factor type A domain