positive regulation of vascular endothelial growth factor receptor signaling pathway
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
endodermal cell differentiation
positive regulation of cell migration
heterotypic cell-cell adhesion
wound healing, spreading of epidermal cells
extracellular matrix organization
memory
cell-cell adhesion mediated by integrin
positive regulation of sprouting angiogenesis
cell-substrate adhesion
cell adhesion
angiogenesis
positive regulation of peptidyl-tyrosine phosphorylation
cell-substrate junction assembly
integrin-mediated signaling pathway
viral entry into host cell
viral process
negative regulation of anoikis
leukocyte migration
positive regulation of cell-substrate adhesion
regulation of angiogenesis
cell adhesion mediated by integrin
female pregnancy
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
3678
16402
Ensembl
ENSG00000161638
ENSMUSG00000000555
UniProt
P08648
P11688
RefSeq (mRNA)
NM_002205
NM_010577 NM_001314041
RefSeq (protein)
NP_002196
NP_001300970 NP_034707
Location (UCSC)
Chr 12: 54.4 – 54.42 Mb
Chr 15: 103.25 – 103.28 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Integrin alpha-5 is a protein that in humans is encoded by the ITGA5 gene.[5]
The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain. Alpha chain 5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.[6]
^ abcGRCh38: Ensembl release 89: ENSG00000161638 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000000555 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Sosnoski DM, Emanuel BS, Hawkins AL, van Tuinen P, Ledbetter DH, Nussbaum RL, Kaos FT, Schwartz E, Phillips D, Bennett JS, et al. (Aug 1988). "Chromosomal localization of the genes for the vitronectin and fibronectin receptors alpha subunits and for platelet glycoproteins IIb and IIIa". J Clin Invest. 81 (6): 1993–8. doi:10.1172/JCI113548. PMC 442653. PMID 2454952.
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Global Information
