Anti-convulsant medicine used to treat seizures in dogs
Imepitoin Trade names Pexion Other names AWD 131-138; ELB-138 Routes of administration Oral ATCvet code
3-(4-Chlorophenyl)-5-morpholin-4-yl-4H -imidazol-2-one
CAS Number PubChem CID ChemSpider UNII ChEMBL CompTox Dashboard (EPA ) DTXSID50172160 ECHA InfoCard 100.220.751 Formula C 13 H 14 Cl N 3 O 2 Molar mass 279.72 g·mol−1 3D model (JSmol)
C1COCCN1C2=NC(=O)N(C2)C3=CC=C(C=C3)Cl
InChI=1S/C13H14ClN3O2/c14-10-1-3-11(4-2-10)17-9-12(15-13(17)18)16-5-7-19-8-6-16/h1-4H,5-9H2
Key:IQHYCZKIFIHTAI-UHFFFAOYSA-N
Imepitoin (INN Tooltip International Nonproprietary Name ), sold under the brand name Pexion , is an anticonvulsant which is used in veterinary medicine in Europe to treat epilepsy in dogs.[1] [2] [3] [4] It was recently[when? ] approved in the United States.[2] [3] [4] The drug also has anxiolytic effects.[1] [2] It was originally developed to treat epilepsy in humans, but clinical trials were terminated upon findings of unfavorable metabolic differences in smokers and non-smokers.[1] [2]
Imepitoin acts as a low-affinity (4,350–5,140 nM; relative to Ki = 6.8 nM for diazepam and Ki = 1.7 nM for clonazepam) partial agonist of the benzodiazepine site of the GABAA receptor (up to 12–21% of the maximal potentiation of diazepam, a full agonist of this site).[1] It is the first partial agonist to be approved for the treatment of epilepsy.[1] The drug also dose-dependently blocks voltage-gated calcium channels.[3] It is not a benzodiazepine; instead, it is an imidazolone, and bears some structural similarities to hydantoin anticonvulsants like ethotoin and phenytoin.[1]
^ a b c d e f Rundfeldt C, Löscher W (2014). "The pharmacology of imepitoin: the first partial benzodiazepine receptor agonist developed for the treatment of epilepsy". CNS Drugs . 28 (1): 29–43. doi:10.1007/s40263-013-0129-z. PMID 24357084. S2CID 31627280.
^ a b c d Sanders S (29 April 2015). "Antiseizure Medications". Seizures in Dogs and Cats . Wiley. pp. 209–. ISBN 978-1-118-68970-7 .
^ a b c Thomas WB, Dewey CW (8 September 2015). "Seizures and Narcolepsy". In Dewey CW, da Costa RC (eds.). Practical Guide to Canine and Feline Neurology . Wiley. p. 259. ISBN 978-1-119-06204-2 .
^ a b "Imepitoin". drugs.com . Archived from the original on 2019-06-17. Retrieved 2017-09-17 .
Last Update: 2023-12-24T08:32:24Z
Imepitoin (INNTooltip International Nonproprietary Name), sold under the brand name Pexion, is an anticonvulsant which is used in veterinary medicine...
Word Count : 279
Last Update: 2024-06-25T23:54:44Z
Elpetrigine Ethadione Ethanol (alcohol) Ethosuximide Fasudil Fendiline Fostedil Imepitoin JTV-519 Lidoflazine Magnesium Manoalide Mesuximide Monatepil Naftopidil...
Word Count : 17896
Last Update: 2024-04-27T04:29:23Z
behaviors. Imepitoin , also known by its brand name Pexion, is a recently developed drug for treating primarily canine epilepsy. Imepitoin is a low-affinity...
Word Count : 4540
Last Update: 2024-06-15T16:22:11Z
Elpetrigine Ethadione Ethanol (alcohol) Ethosuximide Fasudil Fendiline Fostedil Imepitoin JTV-519 Lidoflazine Magnesium Manoalide Mesuximide Monatepil Naftopidil...
Word Count : 11401
Last Update: 2024-06-09T07:53:12Z
CGS-9896 CGS-13767 CGS-20625 CL-218,872 CP-615,003 CTP-354 ELB-139 GBLD-345 Imepitoin JM-1232 L-838,417 Lirequinil (Ro41-3696) NS-2664 NS-2710 NS-11394 Pipequaline...
Word Count : 9417
Last Update: 2024-06-24T22:43:06Z
CGS-9896 CGS-13767 CGS-20625 CL-218,872 CP-615,003 CTP-354 ELB-139 GBLD-345 Imepitoin JM-1232 L-838,417 Lirequinil (Ro41-3696) NS-2664 NS-2710 NS-11394 Pipequaline...
Word Count : 10062
Last Update: 2024-06-17T06:10:20Z
Elpetrigine Ethadione Ethanol (alcohol) Ethosuximide Fasudil Fendiline Fostedil Imepitoin JTV-519 Lidoflazine Magnesium Manoalide Mesuximide Monatepil Naftopidil...
Word Count : 8632
Last Update: 2024-05-25T10:45:05Z
CGS-9896 CGS-13767 CGS-20625 CL-218,872 CP-615,003 CTP-354 ELB-139 GBLD-345 Imepitoin JM-1232 L-838,417 Lirequinil (Ro41-3696) NS-2664 NS-2710 NS-11394 Pipequaline...
Word Count : 1924
Last Update: 2024-05-19T18:14:47Z
CGS-9896 CGS-13767 CGS-20625 CL-218,872 CP-615,003 CTP-354 ELB-139 GBLD-345 Imepitoin JM-1232 L-838,417 Lirequinil (Ro41-3696) NS-2664 NS-2710 NS-11394 Pipequaline...
Word Count : 2425
Last Update: 2024-05-13T23:06:16Z
CGS-9896 CGS-13767 CGS-20625 CL-218,872 CP-615,003 CTP-354 ELB-139 GBLD-345 Imepitoin JM-1232 L-838,417 Lirequinil (Ro41-3696) NS-2664 NS-2710 NS-11394 Pipequaline...
Word Count : 3083
Last Update: 2024-04-05T05:21:37Z
Elpetrigine Ethadione Ethanol (alcohol) Ethosuximide Fasudil Fendiline Fostedil Imepitoin JTV-519 Lidoflazine Magnesium Manoalide Mesuximide Monatepil Naftopidil...
Word Count : 1711
Last Update: 2024-05-26T06:54:59Z
CGS-9896 CGS-13767 CGS-20625 CL-218,872 CP-615,003 CTP-354 ELB-139 GBLD-345 Imepitoin JM-1232 L-838,417 Lirequinil (Ro41-3696) NS-2664 NS-2710 NS-11394 Pipequaline...
Word Count : 8518
Last Update: 2024-06-22T20:56:04Z
Elpetrigine Ethadione Ethanol (alcohol) Ethosuximide Fasudil Fendiline Fostedil Imepitoin JTV-519 Lidoflazine Magnesium Manoalide Mesuximide Monatepil Naftopidil...
Word Count : 4803
Last Update: 2024-06-21T21:53:44Z
CGS-9896 CGS-13767 CGS-20625 CL-218,872 CP-615,003 CTP-354 ELB-139 GBLD-345 Imepitoin JM-1232 L-838,417 Lirequinil (Ro41-3696) NS-2664 NS-2710 NS-11394 Pipequaline...
Word Count : 7752
Last Update: 2024-05-25T11:10:50Z
Elpetrigine Ethadione Ethanol (alcohol) Ethosuximide Fasudil Fendiline Fostedil Imepitoin JTV-519 Lidoflazine Magnesium Manoalide Mesuximide Monatepil Naftopidil...
Word Count : 2681
Last Update: 2024-06-27T10:52:51Z
CGS-9896 CGS-13767 CGS-20625 CL-218,872 CP-615,003 CTP-354 ELB-139 GBLD-345 Imepitoin JM-1232 L-838,417 Lirequinil (Ro41-3696) NS-2664 NS-2710 NS-11394 Pipequaline...
Word Count : 15741
Last Update: 2024-06-20T06:19:56Z
CGS-9896 CGS-13767 CGS-20625 CL-218,872 CP-615,003 CTP-354 ELB-139 GBLD-345 Imepitoin JM-1232 L-838,417 Lirequinil (Ro41-3696) NS-2664 NS-2710 NS-11394 Pipequaline...
Word Count : 9994
Last Update: 2024-06-17T19:02:20Z
CGS-9896 CGS-13767 CGS-20625 CL-218,872 CP-615,003 CTP-354 ELB-139 GBLD-345 Imepitoin JM-1232 L-838,417 Lirequinil (Ro41-3696) NS-2664 NS-2710 NS-11394 Pipequaline...
Word Count : 5298
Last Update: 2024-06-17T02:12:11Z
CGS-9896 CGS-13767 CGS-20625 CL-218,872 CP-615,003 CTP-354 ELB-139 GBLD-345 Imepitoin JM-1232 L-838,417 Lirequinil (Ro41-3696) NS-2664 NS-2710 NS-11394 Pipequaline...
Word Count : 16623
Last Update: 2024-06-25T19:57:03Z
Elpetrigine Ethadione Ethanol (alcohol) Ethosuximide Fasudil Fendiline Fostedil Imepitoin JTV-519 Lidoflazine Magnesium Manoalide Mesuximide Monatepil Naftopidil...
Word Count : 7883
Last Update: 2024-06-22T04:43:49Z
Elpetrigine Ethadione Ethanol (alcohol) Ethosuximide Fasudil Fendiline Fostedil Imepitoin JTV-519 Lidoflazine Magnesium Manoalide Mesuximide Monatepil Naftopidil...
Word Count : 3134
Last Update: 2024-06-22T23:49:03Z
CGS-9896 CGS-13767 CGS-20625 CL-218,872 CP-615,003 CTP-354 ELB-139 GBLD-345 Imepitoin JM-1232 L-838,417 Lirequinil (Ro41-3696) NS-2664 NS-2710 NS-11394 Pipequaline...
Word Count : 8363
Last Update: 2024-05-29T04:59:57Z
CGS-9896 CGS-13767 CGS-20625 CL-218,872 CP-615,003 CTP-354 ELB-139 GBLD-345 Imepitoin JM-1232 L-838,417 Lirequinil (Ro41-3696) NS-2664 NS-2710 NS-11394 Pipequaline...
Word Count : 2516
Last Update: 2024-05-11T09:25:39Z
CGS-9896 CGS-13767 CGS-20625 CL-218,872 CP-615,003 CTP-354 ELB-139 GBLD-345 Imepitoin JM-1232 L-838,417 Lirequinil (Ro41-3696) NS-2664 NS-2710 NS-11394 Pipequaline...
Word Count : 11590
Last Update: 2024-05-25T11:05:23Z
CGS-9896 CGS-13767 CGS-20625 CL-218,872 CP-615,003 CTP-354 ELB-139 GBLD-345 Imepitoin JM-1232 L-838,417 Lirequinil (Ro41-3696) NS-2664 NS-2710 NS-11394 Pipequaline...
Word Count : 5832
Last Update: 2024-05-31T17:06:21Z
Elpetrigine Ethadione Ethanol (alcohol) Ethosuximide Fasudil Fendiline Fostedil Imepitoin JTV-519 Lidoflazine Magnesium Manoalide Mesuximide Monatepil Naftopidil...
Word Count : 7311
Last Update: 2024-06-04T10:47:23Z
CGS-9896 CGS-13767 CGS-20625 CL-218,872 CP-615,003 CTP-354 ELB-139 GBLD-345 Imepitoin JM-1232 L-838,417 Lirequinil (Ro41-3696) NS-2664 NS-2710 NS-11394 Pipequaline...
Word Count : 5625
Last Update: 2024-06-07T19:24:56Z
Elpetrigine Ethadione Ethanol (alcohol) Ethosuximide Fasudil Fendiline Fostedil Imepitoin JTV-519 Lidoflazine Magnesium Manoalide Mesuximide Monatepil Naftopidil...
Word Count : 2750