Hepatocyte nuclear factors (HNFs) are a group of phylogenetically unrelated transcription factors that regulate the transcription of a diverse group of genes into proteins. These proteins include blood clotting factors and in addition, enzymes and transporters involved with glucose, cholesterol, and fatty acid transport and metabolism.[1][2]
^Costa RH, Kalinichenko VV, Holterman AX, Wang X (2003). "Transcription factors in liver development, differentiation, and regeneration". Hepatology. 38 (6): 1331–47. doi:10.1016/j.hep.2003.09.034. PMID 14647040. S2CID 2646966.
^Mitchell SM, Frayling TM (2002). "The role of transcription factors in maturity-onset diabetes of the young". Mol Genet Metab. 77 (1–2): 35–43. doi:10.1016/S1096-7192(02)00150-6. PMID 12359128.
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Hepatocytenuclearfactors (HNFs) are a group of phylogenetically unrelated transcription factors that regulate the transcription of a diverse group of...
Hepatocytenuclearfactor 4 alpha (HNF4A) also known as NR2A1 (nuclear receptor subfamily 2, group A, member 1) is a nuclear receptor that in humans is...
receptor that in humans is encoded by the HNF4G gene. Hepatocytenuclearfactor 4 Hepatocytenuclearfactors GRCh38: Ensembl release 89: ENSG00000164749 – Ensembl...
for example, hepatocytenuclearfactors). Hence, the combinatorial use of a subset of the approximately 2000 human transcription factors easily accounts...
B (hepatocytenuclearfactor 1 homeobox B), also known as HNF1B or transcription factor 2 (TCF2), is a human gene. HNF1B encodes hepatocytenuclear factor...
Forkhead box protein A2 (FOXA2), also known as hepatocytenuclearfactor 3-beta (HNF-3B), is a transcription factor that plays an important role during development...
Hepatocyte growth factor receptor (HGF receptor) is a protein that in humans is encoded by the MET gene. The protein possesses tyrosine kinase activity...
Macrophage-stimulating protein (MSP), also known as hepatocyte growth factor-like protein (HLP, HGFL, or HGFLP), is a protein that in humans is encoded...
PMID 22912808. Guan M, Qu L, Tan W, Chen L, Wong CW (February 2011). "Hepatocytenuclearfactor-4 α regulates liver triglyceride metabolism in part through secreted...
Nuclear receptors bind directly to DNA regulating the expression of adjacent genes; hence these receptors are classified as transcription factors. The...
also known as hepatocytenuclearfactor 3-alpha (HNF-3A), is a protein that in humans is encoded by the FOXA1 gene. FOXA1 is a pioneer factor, a transcription...
a member of the forkhead class of DNA-binding proteins. These hepatocytenuclearfactors are transcriptional activators for liver-specific transcripts...
"Activation of nicotinamide N-methyltransferase gene promoter by hepatocytenuclearfactor-1beta in human papillary thyroid cancer cells". Mol. Endocrinol...
communication between β-catenin (inside the hepatocyte) and the growth factors EGFR and HGFR or c-Met (outside the hepatocyte). The presence of these two proteins...
enzyme regulates the homodimerization of the transcription factorhepatocytenuclearfactor 1 (HNF1). Mutations of the PCBD1 gene cause pterin-4 alpha-carbinolamine...
cytokines and growth factors. Growth factors stimulate cells to speed their rate of division. Platelets release other proinflammatory factors like serotonin...
transcription factors. SHP is unusual for a nuclear receptor in that it lacks a DNA binding domain. Therefore, it is technically neither a transcription factor nor...
chromosome 12. This gene codes for hepatocytenuclearfactor 4-alpha (HNF4-α) protein also known as transcription factor 14 (TCF14). HNF4α controls function...
necrosis factor receptor members such as TRAF6, which results in the release of nuclearfactor κB (NF-κB) transcription activator. NF-κB regulates nuclear gene...
2016-04-13. Rausa FM, Tan Y, Costa RH (2003). "Association between hepatocytenuclearfactor 6 (HNF-6) and FoxA2 DNA binding domains stimulates FoxA2 transcriptional...
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