NNMT information

NNMT
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3ROD, 2IIP
Identifiers
Aliases	NNMT, Nnmt, nicotinamide N-methyltransferase
External IDs	OMIM: 600008 MGI: 1099443 HomoloGene: 4496 GeneCards: NNMT
Gene location (Human)
Chr.	Chromosome 11 (human)
End	114,313,285 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	48,516,453 bp
RNA expression pattern
	Top expressed in
	pericardium; ; vena cava; ; right lobe of liver; ; Achilles tendon; ; ascending aorta; ; popliteal artery; ; gastric mucosa; ; left coronary artery; ; synovial joint; ; saphenous vein;
	Top expressed in
	left lobe of liver; ; subcutaneous adipose tissue; ; white adipose tissue; ; intercostal muscle; ; calvaria; ; ascending aorta; ; aortic valve; ; body of femur; ; brown adipose tissue; ; barrel cortex;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	methyltransferase activity; transferase activity; nicotinamide N-methyltransferase activity; pyridine N-methyltransferase activity;
Cellular component	cytoplasm; cytosol;
Biological process	methylation; animal organ regeneration; response to organonitrogen compound; NAD biosynthesis via nicotinamide riboside salvage pathway;
	Sources:Amigo / QuickGO
Orthologs
	4837
	18113
	ENSG00000166741
	ENSMUSG00000032271
	P40261
	O55239
	NM_006169
	NM_001311062; NM_010924
	NP_006160; NP_001358974; NP_001358975; NP_001358976
	NP_001297991; NP_035054
	Wikidata
View/Edit Human	View/Edit Mouse

Nicotinamide N-methyltransferase (NNMT) is an enzyme that in humans is encoded by the NNMT gene.^[5] NNMT catalyzes the methylation of nicotinamide and similar compounds using the methyl donor S-adenosyl methionine (SAM-e) to produce S-adenosyl-L-homocysteine (SAH) and 1-methylnicotinamide.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000166741 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032271 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Aksoy S, Brandriff BF, Ward A, Little PF, Weinshilboum RM (Mar 1996). "Human nicotinamide N-methyltransferase gene: molecular cloning, structural characterization and chromosomal localization". Genomics. 29 (3): 555–61. doi:10.1006/geno.1995.9966. PMID 8575745.
^ Pissios P (2017). "Nicotinamide N-Methyltransferase: More Than a Vitamin B3 Clearance Enzym". Trends in Endocrinology and Metabolism. 28 (5): 340–353. doi:10.1016/j.tem.2017.02.004. PMC 5446048. PMID 28291578.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000166741 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000032271 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8575745-5] Aksoy S, Brandriff BF, Ward A, Little PF, Weinshilboum RM (Mar 1996). "Human nicotinamide N-methyltransferase gene: molecular cloning, structural characterization and chromosomal localization". Genomics. 29 (3): 555–61. doi:10.1006/geno.1995.9966. PMID 8575745.

[pmid28291578-6] Pissios P (2017). "Nicotinamide N-Methyltransferase: More Than a Vitamin B3 Clearance Enzym". Trends in Endocrinology and Metabolism. 28 (5): 340–353. doi:10.1016/j.tem.2017.02.004. PMC 5446048. PMID 28291578.

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