negative regulation of transcription by RNA polymerase II
response to glucose
negative regulation of DNA-binding transcription factor activity
negative regulation of gene expression
transcription, DNA-templated
positive regulation of gene expression
animal organ regeneration
transcription initiation from RNA polymerase II promoter
negative regulation of transcription, DNA-templated
positive regulation of insulin secretion
steroid hormone mediated signaling pathway
circadian rhythm
circadian regulation of gene expression
rhythmic process
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
8431
23957
Ensembl
ENSG00000131910
ENSMUSG00000037583
UniProt
Q15466
Q62227
RefSeq (mRNA)
NM_021969
NM_011850
RefSeq (protein)
NP_068804
NP_035980
Location (UCSC)
Chr 1: 26.91 – 26.91 Mb
Chr 4: 133.28 – 133.28 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
The small heterodimer partner (SHP) also known as NR0B2 (nuclear receptor subfamily 0, group B, member 2) is a protein that in humans is encoded by the NR0B2 gene.[5] SHP is a member of the nuclear receptor family of intracellular transcription factors.[6] SHP is unusual for a nuclear receptor in that it lacks a DNA binding domain. Therefore, it is technically neither a transcription factor nor nuclear receptor but nevertheless it is still classified as such due to relatively high sequence homology with other nuclear receptor family members.
^ abcGRCh38: Ensembl release 89: ENSG00000131910 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000037583 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Entrez Gene: NR0B2 nuclear receptor subfamily 0, group B, member 2".
^Lee HK, Lee YK, Park SH, Kim YS, Park SH, Lee JW, et al. (June 1998). "Structure and expression of the orphan nuclear receptor SHP gene". The Journal of Biological Chemistry. 273 (23): 14398–402. doi:10.1074/jbc.273.23.14398. PMID 9603951.
and 23 Related for: Small heterodimer partner information
The smallheterodimerpartner (SHP) also known as NR0B2 (nuclear receptor subfamily 0, group B, member 2) is a protein that in humans is encoded by the...
inhibit duodenal secretin expression via orphan nuclear receptor smallheterodimerpartner (SHP)". American Journal of Physiology. Gastrointestinal and Liver...
AMPK activation is required for an increase in the expression of smallheterodimerpartner, which in turn inhibited the expression of the hepatic gluconeogenic...
bind to the CYP7A1 promoter. Rather, FXR induces expression of smallheterodimerpartner (SHP), which then functions to inhibit transcription of the CYP7A1...
Peru and Brazil Single Homeless Project, a UK charity Smallheterodimerpartner, a protein Small hydro power plant Social Democratic People's Party (Turkey)...
Liver X receptor alpha has been shown to interact with EDF1 and smallheterodimerpartner. LXRα activates the transcription factor SREBP-1c, resulting in...
the leucine zipper structures, sMafs form homodimers by themselves and heterodimers with other specific bZIP transcription factors, such as transcription...
down-regulation of gene expression. They generally function as homo/heterodimers. In addition, two additional classes, type III which are a variant of...
of constitutive androstane receptor, farnesoid X receptor, and smallheterodimerpartner. John F. Mustard (MSc 1986, PhD 1990) – Professor of Earth, Environmental...
Ursodeoxycholic acid (UDCA), by upregulating the corepressor smallheterodimerpartner interacting leucine zipper protein (SMILE), inhibits the expression...
Schoonjans K, Botrugno OA, Treuter E, Auwerx J (2002). "The smallheterodimerpartner interacts with the liver X receptor alpha and represses its transcriptional...
Crystal structure of human liver X receptor β(LXRβ) forming heterodimer with its partner retinoid X receptor α(RXRα) on its cognate element, an AGGTCA...
signaling by retinoic acid and serves to phase-shift the clock. Smallheterodimerpartner (SHP). In the liver circadian clock, NPAS2 and SHP engage in a...
which is a heterodimer (subunits SAE1 and SAE2). It is then passed to an E2, which is a conjugating enzyme (Ubc9). Finally, one of a small number of E3...
tried to explain how prions replicate in a protein-only manner was the heterodimer model. This model assumed that a single PrPSc molecule binds to a single...
an extra cysteine bridge, causing it to exist as a homodimer or as a heterodimer with Apo-AII. However, the enhanced cardioprotective activity of this...
25-(OH)2vitamin D3) binds to VDR, which then forms a heterodimer with the retinoid-X receptor. The VDR heterodimer then enters the nucleus and binds to Vitamin...
types in celiac disease patients not carrying the DQA1*05-DQB1*02 (DQ2) heterodimer: results from the European Genetics Cluster on Celiac Disease". Hum....
The functional receptor for IL-23 (the IL-23 receptor) consists of a heterodimer between IL-12Rβ1 and IL-23R. IL-23 was first described by Robert Kastelein...
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