positive regulation of transcription initiation from RNA polymerase II promoter
transcription, DNA-templated
positive regulation of transcription, DNA-templated
glucose import
regulation of pronephros size
positive regulation of transcription by RNA polymerase II
transcription by RNA polymerase II
natural killer cell differentiation
liver development
pancreas development
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
6927
21405
Ensembl
ENSG00000135100
ENSMUSG00000029556
UniProt
P20823
P22361
RefSeq (mRNA)
NM_000545 NM_001306179
NM_009327
RefSeq (protein)
NP_000536 NP_001293108 NP_000536.5 NP_001293108.1
NP_033353
Location (UCSC)
Chr 12: 120.98 – 121 Mb
Chr 5: 115.09 – 115.11 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
HNF1 homeobox A (hepatocyte nuclear factor 1 homeobox A), also known as HNF1A, is a human gene on chromosome 12.[5][6][7] It is ubiquitously expressed in many tissues and cell types.[8] The protein encoded by this gene is a transcription factor that is highly expressed in the liver and is involved in the regulation of the expression of several liver-specific genes.[9] Mutations in the HNF1A gene have been known to cause diabetes.[10] The HNF1A gene also contains a SNP associated with increased risk of coronary artery disease.[11]
^ abcGRCh38: Ensembl release 89: ENSG00000135100 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000029556 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Szpirer C, Riviere M, Cortese R, Nakamura T, Islam MQ, Levan G, Szpirer J (June 1992). "Chromosomal localization in man and rat of the genes encoding the liver-enriched transcription factors C/EBP, DBP, and HNF1/LFB-1 (CEBP, DBP, and transcription factor 1, TCF1, respectively) and of the hepatocyte growth factor/scatter factor gene (HGF)". Genomics. 13 (2): 293–300. doi:10.1016/0888-7543(92)90245-N. PMID 1535333.
^Vaxillaire M, Boccio V, Philippi A, Vigouroux C, Terwilliger J, Passa P, Beckmann JS, Velho G, Lathrop GM, Froguel P (April 1995). "A gene for maturity onset diabetes of the young (MODY) maps to chromosome 12q". Nature Genetics. 9 (4): 418–23. doi:10.1038/ng0495-418. PMID 7795649. S2CID 665243.
^Cite error: The named reference :5 was invoked but never defined (see the help page).
^"BioGPS - your Gene Portal System". biogps.org. Retrieved 2016-10-11.
^Courtois G, Morgan JG, Campbell LA, Fourel G, Crabtree GR (October 1987). "Interaction of a liver-specific nuclear factor with the fibrinogen and alpha 1-antitrypsin promoters". Science. 238 (4827): 688–92. Bibcode:1987Sci...238..688C. doi:10.1126/science.3499668. PMID 3499668.
^Cite error: The named reference :0 was invoked but never defined (see the help page).
^Cite error: The named reference :1 was invoked but never defined (see the help page).
HNF1 homeobox A (hepatocyte nuclear factor 1 homeobox A), also known as HNF1A, is a human gene on chromosome 12. It is ubiquitously expressed in many...
was no consistent decrease in gliclazide clearance in randomly selected HNF1A-MODY and HNF4A-MODY patients. Its classification has been ambiguous, as...
MODY 3 or HNF1A-MODY is a form of maturity-onset diabetes of the young. It is caused by mutations of the HNF1-alpha gene, a homeobox gene on human chromosome...
and Spain TCF Financial Corporation, a holding company TCF Bank TCF-1 or HNF1A, a gene TCF4 or TCF7L2, a protein transcription factor TCF/LEF family of...
ENSG00000188620 Homeodomain Known motif – High-throughput in vitro [366] TAAKTG HNF1A ENSG00000135100 Homeodomain Known motif – High-throughput in vitro [367]...
transcription factor 14 (TCF14). HNF4α controls function of HNF1α (see MODY 3; HNF1A) and perhaps HNF1β (MODY 5) as well. This transcription network plays a...
(November 2007). "Partial and whole gene deletion mutations of the GCK and HNF1A genes in maturity-onset diabetes of the young". Diabetologia. 50 (11): 2313–7...
PMID 11463573. Hepatocyte nuclear factor 1A bound to DNA [1] Different rendering of HNF1a bound to DNA Hepatocyte+Nuclear+Factors at the U.S. National Library of...
couple of genes of interest in Japanese populations. These genes are ADCY5, HNF1A, PRC1 that exhibited this monoallelic effect in Japanese populations and...
tetrahydrobiopterin deficiency. PCBD1 has been shown to interact with DYRK1B and HNF1A. GRCh38: Ensembl release 89: ENSG00000166228 – Ensembl, May 2017 GRCm38:...
activation of protein kinases. RAC3 has been shown to interact with CIB1 and HNF1A. RAC3 also interacts with Nrf2 proteins. ETAR, ILK, and β-arr1 interact...
form heterodimers with another member of this transcription factor family, HNF1A; depending on the HNF1B isoform, the result may be to activate or inhibit...
Global Information
