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Hepatocyte nuclear factor 4 information


Hepatocyte nuclear factor 4 alpha
Identifiers
SymbolHNF4A
Alt. symbolsTCF14, MODY, MODY1
NCBI gene3172
HGNC5024
OMIM600281
PDB1M7W
RefSeqNM_001030004
UniProtP41235
Other data
LocusChr. 20 q12-20q13.1
Search for
StructuresSwiss-model
DomainsInterPro
Hepatocyte nuclear factor 4 gamma
Identifiers
SymbolHNF4G
NCBI gene3174
HGNC5026
OMIM605966
PDB1LV2
RefSeqNM_004133
UniProtQ14541
Other data
LocusChr. 8 q21-q22
Search for
StructuresSwiss-model
DomainsInterPro

HNF4 (Hepatocyte Nuclear Factor 4) is a nuclear receptor protein mostly expressed in the liver, gut, kidney, and pancreatic beta cells that is critical for liver development. In humans, there are two paralogs of HNF4, HNF4α and HNF4γ, encoded by two separate genes HNF4A and HNF4G respectively.[1]

  1. ^ Chartier FL, Bossu JP, Laudet V, Fruchart JC, Laine B (1994). "Cloning and sequencing of cDNAs encoding the human hepatocyte nuclear factor 4 indicate the presence of two isoforms in human liver". Gene. 147 (2): 269–72. doi:10.1016/0378-1119(94)90079-5. PMID 7926813.

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HNF4 (Hepatocyte Nuclear Factor 4) is a nuclear receptor protein mostly expressed in the liver, gut, kidney, and pancreatic beta cells that is critical...

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Hepatocyte nuclear factor 4 gamma (HNF4G) also known as NR2A2 (nuclear receptor subfamily 2, group A, member 2) is a nuclear receptor that in humans is...

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Hepatocyte nuclear factors (HNFs) are a group of phylogenetically unrelated transcription factors that regulate the transcription of a diverse group of...

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Granner DK (1998). "SRC-1 and GRIP1 coactivate transcription with hepatocyte nuclear factor 4". J. Biol. Chem. 273 (47): 30847–50. doi:10.1074/jbc.273.47.30847...

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chromosome 12. This gene codes for hepatocyte nuclear factor 4-alpha (HNF4-α) protein also known as transcription factor 14 (TCF14). HNF4α controls function...

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Granner DK (1998). "SRC-1 and GRIP1 coactivate transcription with hepatocyte nuclear factor 4". J. Biol. Chem. 273 (47): 30847–50. doi:10.1074/jbc.273.47.30847...

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PMID 22912808. Guan M, Qu L, Tan W, Chen L, Wong CW (February 2011). "Hepatocyte nuclear factor-4 α regulates liver triglyceride metabolism in part through secreted...

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prospero-related homeodomain protein is a novel co-regulator of hepatocyte nuclear factor 4 α that regulates the cholesterol 7α-hydroxylase gene". J. Biol...

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communication between β-catenin (inside the hepatocyte) and the growth factors EGFR and HGFR or c-Met (outside the hepatocyte). The presence of these two proteins...

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