FOXA2 information

FOXA2
Identifiers
Aliases	FOXA2, HNF3B, TCF3B, forkhead box A2, HNF-3-beta
External IDs	OMIM: 600288; MGI: 1347476; HomoloGene: 7762; GeneCards: FOXA2; OMA:FOXA2 - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	22,585,455 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	147,888,889 bp
RNA expression pattern
	Top expressed in
	pancreatic ductal cell; ; pylorus; ; buccal mucosa cell; ; beta cell; ; right uterine tube; ; right lobe of liver; ; cardia; ; body of pancreas; ; lower lobe of lung; ; testicle;
	Top expressed in
	endoderm; ; neural plate; ; epithelium of stomach; ; notochord; ; islet of Langerhans; ; embryonic organizer; ; Hindgut; ; mucous cell of stomach; ; pyloric antrum; ; floor plate;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA binding; sequence-specific DNA binding; protein domain specific binding; DNA-binding transcription factor activity; transcription factor binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	cytoplasm; nucleoplasm; cell junction; nucleus;
Biological process	dopaminergic neuron differentiation; regulation of insulin secretion involved in cellular response to glucose stimulus; regulation of transcription, DNA-templated; positive regulation of gastrulation; response to interleukin-6; positive regulation of transcription from RNA polymerase II promoter by glucose; regulation of transcription by RNA polymerase II; cell fate specification; adult locomotory behavior; negative regulation of DNA-binding transcription factor activity; transcription, DNA-templated; positive regulation of transcription, DNA-templated; multicellular organism development; negative regulation of glucokinase activity; negative regulation of detection of glucose; regulation of blood coagulation; positive regulation of embryonic development; primitive streak formation; negative regulation of epithelial to mesenchymal transition; endocrine pancreas development; positive regulation of transcription by RNA polymerase II; positive regulation of cell-cell adhesion mediated by cadherin; anatomical structure morphogenesis; chromatin organization; negative regulation of transcription from RNA polymerase II promoter by glucose; cell differentiation;
	Sources:Amigo / QuickGO
Orthologs
	3170
	15376
	ENSG00000125798
	ENSMUSG00000037025
	Q9Y261
	P35583
	NM_021784; NM_153675
	NM_001291065; NM_001291067; NM_010446
	NP_068556; NP_710141
	NP_001277994; NP_001277996; NP_034576
	Wikidata
View/Edit Human	View/Edit Mouse

Forkhead box protein A2 (FOXA2), also known as hepatocyte nuclear factor 3-beta (HNF-3B), is a transcription factor that plays an important role during development, in mature tissues and, when dysregulated or mutated, also in cancer.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000125798 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000037025 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Golson ML, Kaestner KH (December 2016). "Fox transcription factors: from development to disease". Development. 143 (24): 4558–4570. doi:10.1242/dev.112672. PMC 5201025. PMID 27965437.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000125798 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000037025 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[ref1-5] Golson ML, Kaestner KH (December 2016). "Fox transcription factors: from development to disease". Development. 143 (24): 4558–4570. doi:10.1242/dev.112672. PMC 5201025. PMID 27965437.

FOXA2 information

and 15 Related for: FOXA2 information

FOXA2

ONECUT1

List of human transcription factors

Floxing

FOX proteins

Nuclear receptor 4A2

James Adjaye

List of intestinal epithelial differentiation genes

ISLR

Hepatocyte nuclear factors

Insulated neighborhood

AGR2

Homeobox protein goosecoid

GLIS1

ID4