RNA polymerase II transcription regulatory region sequence-specific DNA binding
transcription corepressor activity
E-box binding
sequence-specific double-stranded DNA binding
Cellular component
cytoplasm
intracellular anatomical structure
nucleus
nucleoplasm
Biological process
pattern specification process
auditory receptor cell fate determination
midbrain-hindbrain boundary morphogenesis
inner ear receptor cell stereocilium organization
negative regulation of neuron differentiation
metanephric nephron tubule morphogenesis
cell morphogenesis involved in neuron differentiation
regulation of transcription by RNA polymerase II
lateral inhibition
cardiac neural crest cell development involved in outflow tract morphogenesis
negative regulation of stem cell differentiation
inner ear auditory receptor cell differentiation
negative regulation of pro-B cell differentiation
negative regulation of inner ear receptor cell differentiation
regulation of neurogenesis
positive regulation of Notch signaling pathway
cochlea development
cell fate commitment
regulation of transcription, DNA-templated
lung development
negative regulation of inner ear auditory receptor cell differentiation
negative regulation of cell differentiation
labyrinthine layer blood vessel development
in utero embryonic development
cell maturation
adenohypophysis development
regulation of timing of neuron differentiation
regulation of fat cell differentiation
transcription, DNA-templated
positive regulation of transcription, DNA-templated
telencephalon development
positive regulation of T cell proliferation
neural tube development
pancreas development
hindbrain morphogenesis
smoothened signaling pathway
negative regulation of stomach neuroendocrine cell differentiation
ureteric bud morphogenesis
regulation of inner ear auditory receptor cell differentiation
oculomotor nerve development
regulation of timing of cell differentiation
nervous system development
cell adhesion
positive regulation of BMP signaling pathway
midbrain development
establishment of epithelial cell polarity
pituitary gland development
comma-shaped body morphogenesis
somatic stem cell population maintenance
trochlear nerve development
aorta morphogenesis
negative regulation of forebrain neuron differentiation
negative regulation of pancreatic A cell differentiation
regulation of secondary heart field cardioblast proliferation
common bile duct development
renal interstitial fibroblast development
forebrain radial glial cell differentiation
S-shaped body morphogenesis
glomerulus vasculature development
liver development
regulation of epithelial cell proliferation
cell migration
positive regulation of transcription by RNA polymerase II
ventricular septum morphogenesis
negative regulation of oligodendrocyte differentiation
ascending aorta morphogenesis
outflow tract morphogenesis
positive regulation of astrocyte differentiation
ventricular septum development
vascular associated smooth muscle cell development
embryonic heart tube morphogenesis
positive regulation of receptor signaling pathway via JAK-STAT
Notch signaling pathway
positive regulation of mitotic cell cycle, embryonic
negative regulation of transcription, DNA-templated
thymus development
positive regulation of DNA binding
negative regulation of glial cell proliferation
neuronal stem cell population maintenance
positive regulation of cell population proliferation
negative regulation of transcription by RNA polymerase II
artery morphogenesis
pharyngeal arch artery morphogenesis
positive regulation of tyrosine phosphorylation of STAT protein
protein-containing complex assembly
regulation of receptor signaling pathway via JAK-STAT
somitogenesis
cell differentiation
anterior/posterior pattern specification
negative regulation of cell fate determination
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
3280
15205
Ensembl
ENSG00000114315
ENSMUSG00000022528
UniProt
Q14469
P35428
RefSeq (mRNA)
NM_005524
NM_008235
RefSeq (protein)
NP_005515
NP_032261
Location (UCSC)
Chr 3: 194.14 – 194.14 Mb
Chr 16: 29.88 – 29.89 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Transcription factor HES1 (hairy and enhancer of split-1) is a protein that is encoded by the Hes1 gene, and is the mammalian homolog of the hairy gene in Drosophila.[5][6] HES1 is one of the seven members of the Hes gene family (HES1-7). Hes genes code nuclear proteins that suppress transcription.[7]
This protein belongs to the basic helix-loop-helix (bHLH) family of transcription factors. It is a transcriptional repressor of genes that require a bHLH protein for their transcription. The protein has a particular type of basic domain that contains a helix interrupting protein that binds to the N-box promoter region rather than the canonical enhancer box (E-box).[6] As a member of the bHLH family, it is a transcriptional repressor that influences cell proliferation and differentiation in embryogenesis.[7] HES1 regulates its own expression via a negative feedback loop, and oscillates with approximately 2-hour periodicity.[8]
^ abcGRCh38: Ensembl release 89: ENSG00000114315 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000022528 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Feder JN, Li L, Jan LY, Jan YN (Jul 1994). "Genomic cloning and chromosomal localization of HRY, the human homolog to the Drosophila segmentation gene, hairy". Genomics. 20 (1): 56–61. doi:10.1006/geno.1994.1126. PMID 8020957.
^ ab"Entrez Gene: HES1 hairy and enhancer of split 1, (Drosophila)".
^ abKageyama R, Ohtsuka T, Kobayashi T (2007). "The Hes gene family: Repressors and oscillators that orchestrate embryogenesis". Development. 134 (7): 1243–1251. doi:10.1242/dev.000786. PMID 17329370. S2CID 1693293.
^Hirata H, Yoshiura S, Ohtsuka T, Bessho Y, Harada T, Yoshikawa K, Kageyama R (October 2002). "Oscillatory Expression of the bHLH Factor Hes1 Regulated by a Negative Feedback Loop". Science. 298 (5594): 840–843. Bibcode:2002Sci...298..840H. doi:10.1126/science.1074560. PMID 12399594. S2CID 30725650.
Transcription factor HES1 (hairy and enhancer of split-1) is a protein that is encoded by the Hes1 gene, and is the mammalian homolog of the hairy gene...
Notch ligands, mutations of which cause various defects. Notch regulates HES1, which sets up the caudal half of the somite. Notch activation turns on LFNG...
neurotransmitter fates is controlled by the dynamic expression of Her6 the homolog of HES1. Expression of this hairy-like bHLH transcription factor, which represses...
humans is encoded by the TCF3 gene. TCF3 has been shown to directly enhance Hes1 (a well-known target of Notch signaling) expression. This gene encodes a...
Inferred motif from similar protein – High-throughput in vitro [334] BBCACGTGY HES1 ENSG00000114315 bHLH Known motif – High-throughput in vitro [335] KDCRCGTGBB...
analysis and gain of function experiments revealed that Notch signaling targets Hes1 in the intestine and regulates a binary cell fate decision between adsorptive...
Sir2-related protein SIRT1 associates with the bHLH repressors HES1 and HEY2 and is involved in HES1- and HEY2-mediated transcriptional repression". Biochemical...
Bessho Y, Hojo M, Kageyama R (Aug 2000). "The bHLH gene Hes6, an inhibitor of Hes1, promotes neuronal differentiation". Development. 127 (13): 2933–43. doi:10...
Rossier C, Lalioti MD, Antonarakis SE (Jun 1997). "Isolation of a human gene (HES1) with homology to an Escherichia coli and a zebrafish protein that maps to...
F, Kageyama R (August 2001). "Roles of the basic helix-loop-helix genes Hes1 and Hes5 in expansion of neural stem cells of the developing brain". The...
subventricular zone and for olfactory behavior regulating cyclins, BMP4, Hes1/5 and Ids". Front Cell Neurosci. 8: 98. doi:10.3389/fncel.2014.00098. PMC 3977348...
microRNA miR-9 targets an important regulator of neuronal differentiation, HES1, allowing for precisely timed waves of neurogenesis. From January 2011 -...
interplay between Shh from the ZLI and the bHLH factor Her6 (homolog to HES1) determines the neuronal identity within the thalamus: Her6 positive cells...
GPO tried again. The 300 series House Exchange System, now known as the HES1, was a combination of the Tele. 332L and the House Telephone System. From...
and FANCM. In complex with FANCF, FANCG and FANCL, FANCA interacts with HES1. This interaction has been proposed as essential for the stability and nuclear...
safeguards neural progenitor maintenance involving transcriptional regulation of Hes1". Proceedings of the National Academy of Sciences. 114 (28): E5599–E5607...
show similarities to limbal stem cells in terms of expression of ABCG2, HES1 and BMI1 in addition to p63. When transplanted onto rabbit eyes with corneal...
Mayanil CS (February 2011). "Role of Pax3 acetylation in the regulation of Hes1 and Neurog2". primary. Molecular Biology of the Cell. 22 (4): 503–12. doi:10...
downstream activation of these Notch target genes. TOX was also found to bind Hes1, a Notch target gene, in embryonic kidney cells. Several ILC3 populations...
Quaggin SE (October 2004). "Expression of Hairy/Enhancer of Split genes, Hes1 and Hes5, during murine nephron morphogenesis". Gene Expression Patterns...
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