BHLHE41 information

BHLHE41
Identifiers
Aliases	BHLHE41, DEC2, SHARP1, BHLHe41, HDEC2, SHARP-1, BHLHB3, Basic Helix-Loop-Helix Family Member E41, Basic Helix-Loop-Helix Family, Member E41, Class E Basic Helix-Loop-Helix Protein 41, Class B Basic Helix-Loop-Helix Protein 3, Basic Helix-Loop-Helix Domain Containing, Class B, 3, Differentially Expressed In Chondrocytes 2, Differentially Expressed In Chondrocytes Protein 2, Enhancer-Of-Split And Hairy-Related Protein 1, FNSS1
External IDs	OMIM: 606200; MGI: 1930704; HomoloGene: 137401; GeneCards: BHLHE41; OMA:BHLHE41 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	26,125,037 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	145,811,284 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; inferior ganglion of vagus nerve; ; Achilles tendon; ; optic nerve; ; subthalamic nucleus; ; spinal cord; ; C1 segment; ; corpus callosum; ; pars reticulata; ; external globus pallidus;
	Top expressed in
	neural layer of retina; ; muscle of thigh; ; zygote; ; superior frontal gyrus; ; primary visual cortex; ; cerebellar cortex; ; dentate gyrus of hippocampal formation granule cell; ; skeletal muscle tissue; ; interventricular septum; ; lip;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; protein dimerization activity; protein homodimerization activity; MRF binding; transcription corepressor activity; histone deacetylase binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; bHLH transcription factor binding; E-box binding; protein binding; protein heterodimerization activity; transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding; DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding; transcription factor binding; sequence-specific DNA binding; sequence-specific double-stranded DNA binding;
Cellular component	nucleus;
Biological process	cell differentiation; regulation of transcription, DNA-templated; rhythmic process; negative regulation of transcription by competitive promoter binding; negative regulation of transcription by RNA polymerase II; circadian regulation of gene expression; transcription, DNA-templated; negative regulation of myotube differentiation; animal organ morphogenesis; cell population proliferation; negative regulation of transcription, DNA-templated; circadian rhythm; somitogenesis; Notch signaling pathway; regulation of neurogenesis; anterior/posterior pattern specification;
	Sources:Amigo / QuickGO
Orthologs
	79365
	79362
	ENSG00000123095
	ENSMUSG00000030256
	Q9C0J9
	Q99PV5
	NM_030762
	NM_001271768; NM_024469
	NP_110389
	NP_001258697; NP_077789
	Wikidata
View/Edit Human	View/Edit Mouse

"Basic helix-loop-helix family, member e41", or BHLHE41, is a gene that encodes a basic helix-loop-helix transcription factor repressor protein in various tissues of both humans and mice.^[5]^[6]^[7]^[8] It is also known as DEC2, hDEC2, and SHARP1, and was previously known as "basic helix-loop-helix domain containing, class B, 3", or BHLHB3.^[9] BHLHE41 is known for its role in the circadian molecular mechanisms that influence sleep quantity as well as its role in immune function and the maturation of T helper type 2 cell lineages associated with humoral immunity.^[10]^[11]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000123095 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000030256 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "BHLHE41 basic helix-loop-helix family, member e41 [ Homo sapiens (human) ]". National Center for Biotechnology Information.
^ "Bhlhe41 basic helix-loop-helix family, member e41 [ Mus musculus (house mouse) ]". NCBI.
^ Stevens JD, Roalson EH, Skinner MK (November 2008). "Phylogenetic and expression analysis of the basic helix-loop-helix transcription factor gene family: genomic approach to cellular differentiation". Differentiation; Research in Biological Diversity. 76 (9): 1006–22. doi:10.1111/j.1432-0436.2008.00285.x. PMC 5728086. PMID 18557763.
^ "Entrez Gene: BHLHB3 basic helix-loop-helix domain containing, class B, 3".
^ "Basic Helix-Loop-Helix Family, Member E41". Weizmann Institute of Science. Archived from the original on 2014-05-28. Retrieved 2014-05-27.
^ Cite error: The named reference Kurien_2013 was invoked but never defined (see the help page).
^ Yang XO, Angkasekwinai P, Zhu J, Peng J, Liu Z, Nurieva R, Liu X, Chung Y, Chang SH, Sun B, Dong C (December 2009). "Requirement for the basic helix-loop-helix transcription factor Dec2 in initial TH2 lineage commitment". Nature Immunology. 10 (12): 1260–6. doi:10.1038/ni.1821. PMC 2784129. PMID 19881507.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000123095 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000030256 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[NCBI_human-5] "BHLHE41 basic helix-loop-helix family, member e41 [ Homo sapiens (human) ]". National Center for Biotechnology Information.

[NCBI_mouse-6] "Bhlhe41 basic helix-loop-helix family, member e41 [ Mus musculus (house mouse) ]". NCBI.

[pmid18557763-7] Stevens JD, Roalson EH, Skinner MK (November 2008). "Phylogenetic and expression analysis of the basic helix-loop-helix transcription factor gene family: genomic approach to cellular differentiation". Differentiation; Research in Biological Diversity. 76 (9): 1006–22. doi:10.1111/j.1432-0436.2008.00285.x. PMC 5728086. PMID 18557763.

[entrez-8] "Entrez Gene: BHLHB3 basic helix-loop-helix domain containing, class B, 3".

[Weizmann-9] "Basic Helix-Loop-Helix Family, Member E41". Weizmann Institute of Science. Archived from the original on 2014-05-28. Retrieved 2014-05-27.

[Kurien_2013-10] Cite error: The named reference Kurien_2013 was invoked but never defined (see the help page).

[11] Yang XO, Angkasekwinai P, Zhu J, Peng J, Liu Z, Nurieva R, Liu X, Chung Y, Chang SH, Sun B, Dong C (December 2009). "Requirement for the basic helix-loop-helix transcription factor Dec2 in initial TH2 lineage commitment". Nature Immunology. 10 (12): 1260–6. doi:10.1038/ni.1821. PMC 2784129. PMID 19881507.

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