HES6 information

HES6
Identifiers
Aliases	HES6, C-HAIRY1, HES-6, bHLHb41, bHLHc23, hes family bHLH transcription factor 6
External IDs	OMIM: 610331 MGI: 1859852 HomoloGene: 23111 GeneCards: HES6
Gene location (Human)
Chr.	Chromosome 2 (human)
End	238,240,662 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	91,341,760 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; secondary oocyte; ; anterior pituitary; ; Brodmann area 9; ; cingulate gyrus; ; amygdala; ; right uterine tube; ; prefrontal cortex; ; endothelial cell; ; hypothalamus;
	Top expressed in
	fossa; ; internal carotid artery; ; adrenal gland; ; saccule; ; ganglionic eminence; ; left lobe of liver; ; Paneth cell; ; proximal tubule; ; medial ganglionic eminence; ; condyle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; transcription factor binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; protein dimerization activity; DNA-binding transcription repressor activity, RNA polymerase II-specific; DNA-binding transcription factor activity; transcription coregulator activity; DNA-binding transcription factor activity, RNA polymerase II-specific; transcription corepressor activity; sequence-specific DNA binding; sequence-specific double-stranded DNA binding;
Cellular component	nucleus; transcription regulator complex;
Biological process	regulation of transcription by RNA polymerase II; multicellular organism development; cell differentiation; negative regulation of transcription by RNA polymerase II; transcription, DNA-templated; nervous system development; regulation of transcription, DNA-templated; somitogenesis; Notch signaling pathway; regulation of neurogenesis; anterior/posterior pattern specification;
	Sources:Amigo / QuickGO
Orthologs
	55502
	55927
	ENSG00000144485
	ENSMUSG00000067071
	Q96HZ4
	Q9JHE6
	NM_018645; NM_001142853; NM_001282434
	NM_019479; NM_001360899; NM_001360900
	NP_001136325; NP_001269363; NP_061115
	NP_062352; NP_001347828; NP_001347829
	Wikidata
View/Edit Human	View/Edit Mouse

Transcription cofactor HES-6 is a protein that in humans is encoded by the HES6 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000144485 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000067071 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Bae S, Bessho Y, Hojo M, Kageyama R (Aug 2000). "The bHLH gene Hes6, an inhibitor of Hes1, promotes neuronal differentiation". Development. 127 (13): 2933–43. doi:10.1242/dev.127.13.2933. PMID 10851137.
^ "Entrez Gene: HES6 hairy and enhancer of split 6 (Drosophila)".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000144485 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000067071 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10851137-5] Bae S, Bessho Y, Hojo M, Kageyama R (Aug 2000). "The bHLH gene Hes6, an inhibitor of Hes1, promotes neuronal differentiation". Development. 127 (13): 2933–43. doi:10.1242/dev.127.13.2933. PMID 10851137.

[entrez-6] "Entrez Gene: HES6 hairy and enhancer of split 6 (Drosophila)".

HES6 information

and 6 Related for: HES6 information

HES6

List of human transcription factors

List of distinct cell types in the adult human body

TLE1

HES1

ATOH1