positive regulation of natural killer cell differentiation
lymph node development
Peyer's patch development
regulation of transcription by RNA polymerase II
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
9760
252838
Ensembl
ENSG00000198846
ENSMUSG00000041272
UniProt
O94900
Q66JW3
RefSeq (mRNA)
NM_014729
NM_145711 NM_001377078 NM_001377079
RefSeq (protein)
NP_055544
NP_663757 NP_001364007 NP_001364008
Location (UCSC)
Chr 8: 58.81 – 59.12 Mb
Chr 4: 6.69 – 6.99 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
TOX pathway
Thymocyte selection-associated high mobility group box protein TOX is a protein that in humans is encoded by the TOX gene.[5][6][7] TOX drives T-cell exhaustion[8][9] and plays a role in innate lymphoid cell development.[10][11]
^ abcGRCh38: Ensembl release 89: ENSG00000198846 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000041272 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, et al. (October 1998). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 5 (5): 277–286. doi:10.1093/dnares/5.5.277. PMID 9872452.
^Wilkinson B, Chen JY, Han P, Rufner KM, Goularte OD, Kaye J (March 2002). "TOX: an HMG box protein implicated in the regulation of thymocyte selection". Nature Immunology. 3 (3): 272–280. doi:10.1038/ni767. PMID 11850626. S2CID 19716719.
^"Entrez Gene: thymocyte selection-associated high mobility group box gene TOX".
^Bordon Y (August 2019). "TOX for tired T cells". Nature Reviews. Immunology. 19 (8): 476. doi:10.1038/s41577-019-0193-9. PMID 31243349.
^Cite error: The named reference :1 was invoked but never defined (see the help page).
^Cite error: The named reference :2 was invoked but never defined (see the help page).
^Cite error: The named reference :3 was invoked but never defined (see the help page).
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690G0D6V8H KEGG D08098 Y HCl: D00711 Y ChEBI CHEBI:6121 Y ChEMBL ChEMBL742 Y CompTox Dashboard (EPA) DTXSID8023187 ECHA InfoCard 100.027.095 Chemical and physical...
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management: nonclinical Pharm/Tox analysis and the role of comparative toxicology". Toxicology. 236 (1–2): 1–6. doi:10.1016/j.tox.2007.04.005. PMID 17507137...
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