TCF3 information

TCF3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2MH0, 2YPA, 2YPB, 3U5V
Identifiers
Aliases	TCF3, E2A, E47, ITF1, TCF-3, VDIR, bHLHb21, AGM8, transcription factor 3, p75
External IDs	OMIM: 147141; MGI: 98510; HomoloGene: 2408; GeneCards: TCF3; OMA:TCF3 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	1,652,605 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	80,269,481 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; pancreatic ductal cell; ; lymph node; ; bone marrow cells; ; appendix; ; stromal cell of endometrium; ; spleen; ; trabecular bone; ; parotid gland; ; blood;
	Top expressed in
	maxillary prominence; ; lip; ; somite; ; abdominal wall; ; yolk sac; ; internal carotid artery; ; renal corpuscle; ; thymus; ; external carotid artery; ; medullary collecting duct;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; sequence-specific DNA binding; protein dimerization activity; protein homodimerization activity; DNA-binding transcription factor activity; mitogen-activated protein kinase kinase kinase binding; vitamin D response element binding; transcription coactivator activity; transcription factor binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; bHLH transcription factor binding; E-box binding; protein binding; protein heterodimerization activity; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	cytoplasm; transcription regulator complex; RNA polymerase II transcription regulator complex; nucleus; nuclear speck; nucleoplasm; protein-containing complex;
Biological process	cell differentiation; regulation of transcription, DNA-templated; positive regulation of muscle cell differentiation; positive regulation of DNA-binding transcription factor activity; negative regulation of transcription by RNA polymerase II; transcription, DNA-templated; nervous system development; positive regulation of transcription, DNA-templated; regulation of G1/S transition of mitotic cell cycle; B cell lineage commitment; positive regulation of cell cycle; positive regulation of B cell proliferation; positive regulation of neuron differentiation; B cell differentiation; immunoglobulin V(D)J recombination; positive regulation of transcription by RNA polymerase II; regulation of hematopoietic stem cell differentiation;
	Sources:Amigo / QuickGO
Orthologs
	6929
	21423
	ENSG00000071564
	ENSMUSG00000020167
	P15923
	P15806
	NM_001136139; NM_003200; NM_001351778; NM_001351779
NM_001164147; NM_001164148; NM_001164149; NM_001164150; NM_001164151;
	NM_001164152; NM_001164153; NM_011548; NM_001378903; NM_001378904; NM_001378905; NM_001378908; NM_001378910; NM_001378912; NM_001378913; NM_001378914
	NP_001129611; NP_003191; NP_001338707; NP_001338708
NP_001157619; NP_001157620; NP_001157621; NP_001157622; NP_001157623;
	NP_001157624; NP_001157625; NP_035678; NP_001365832; NP_001365833; NP_001365834; NP_001365837; NP_001365839; NP_001365841; NP_001365842; NP_001365843
	Wikidata
View/Edit Human	View/Edit Mouse

Transcription factor 3 (E2A immunoglobulin enhancer-binding factors E12/E47), also known as TCF3, is a protein that in humans is encoded by the TCF3 gene.^[5]^[6]^[7] TCF3 has been shown to directly enhance Hes1 (a well-known target of Notch signaling) expression.^[8]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000071564 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020167 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: TCF3".
^ Henthorn P, McCarrick-Walmsley R, Kadesch T (Feb 1990). "Sequence of the cDNA encoding ITF-1, a positive-acting transcription factor". Nucleic Acids Research. 18 (3): 677. doi:10.1093/nar/18.3.677. PMC 333499. PMID 2308859.
^ Kamps MP, Murre C, Sun XH, Baltimore D (Feb 1990). "A new homeobox gene contributes the DNA binding domain of the t(1;19) translocation protein in pre-B ALL". Cell. 60 (4): 547–55. doi:10.1016/0092-8674(90)90658-2. PMID 1967983. S2CID 39661371.
^ E proteins and Notch signaling cooperate to promote T cell lineage specification and commitment

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000071564 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020167 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez_6929-5] "Entrez Gene: TCF3".

[pmid2308859-6] Henthorn P, McCarrick-Walmsley R, Kadesch T (Feb 1990). "Sequence of the cDNA encoding ITF-1, a positive-acting transcription factor". Nucleic Acids Research. 18 (3): 677. doi:10.1093/nar/18.3.677. PMC 333499. PMID 2308859.

[pmid1967983-7] Kamps MP, Murre C, Sun XH, Baltimore D (Feb 1990). "A new homeobox gene contributes the DNA binding domain of the t(1;19) translocation protein in pre-B ALL". Cell. 60 (4): 547–55. doi:10.1016/0092-8674(90)90658-2. PMID 1967983. S2CID 39661371.

[8] E proteins and Notch signaling cooperate to promote T cell lineage specification and commitment

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