HEY2 information

HEY2
Identifiers
Aliases	HEY2, CHF1, GRIDLOCK, GRL, HERP1, HESR2, HRT2, bHLHb32, hes related family bHLH transcription factor with YRPW motif 2
External IDs	OMIM: 604674; MGI: 1341884; HomoloGene: 22705; GeneCards: HEY2; OMA:HEY2 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	125,761,269 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	30,718,797 bp
RNA expression pattern
	Top expressed in
	popliteal artery; ; right ventricle; ; right coronary artery; ; oocyte; ; secondary oocyte; ; right uterine tube; ; corpus epididymis; ; left coronary artery; ; ascending aorta; ; caput epididymis;
	Top expressed in
	trigeminal ganglion; ; ascending aorta; ; left ventricle; ; cumulus cell; ; semi-lunar valve; ; aortic valve; ; external carotid artery; ; spinal nerve; ; maxillary prominence; ; atrioventricular valve;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	microsatellite binding; sequence-specific DNA binding; DNA binding; protein dimerization activity; protein homodimerization activity; DNA-binding transcription factor activity; transcription factor binding; histone deacetylase binding; RNA polymerase II general transcription initiation factor activity; protein binding; protein heterodimerization activity; DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; transcription corepressor activity; sequence-specific double-stranded DNA binding;
Cellular component	cytoplasm; transcription repressor complex; Sin3 complex; nucleoplasm; nucleus;
Biological process	dorsal aorta morphogenesis; cardiac vascular smooth muscle cell development; cochlea development; pattern specification process; cell fate commitment; pulmonary valve morphogenesis; regulation of inner ear auditory receptor cell differentiation; negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation; regulation of transcription, DNA-templated; heart trabecula formation; tricuspid valve morphogenesis; regulation of vasculogenesis; pulmonary artery morphogenesis; cardiac septum morphogenesis; negative regulation of cardiac vascular smooth muscle cell differentiation; muscular septum morphogenesis; ventricular septum morphogenesis; protein-DNA complex assembly; cardiac muscle hypertrophy; outflow tract morphogenesis; ascending aorta morphogenesis; cardiac left ventricle morphogenesis; labyrinthine layer blood vessel development; negative regulation of transcription by RNA polymerase II; coronary vasculature morphogenesis; smooth muscle cell differentiation; negative regulation of gene expression; endocardial cushion to mesenchymal transition involved in heart valve formation; transcription, DNA-templated; ventricular trabecula myocardium morphogenesis; positive regulation of heart rate; vasculogenesis; multicellular organism development; atrial septum morphogenesis; negative regulation of cardiac muscle cell apoptotic process; heart development; arterial endothelial cell differentiation; positive regulation of cardiac muscle cell proliferation; blood vessel development; cardiac muscle hypertrophy in response to stress; umbilical cord morphogenesis; negative regulation of transcription regulatory region DNA binding; mesenchymal cell development; artery development; regulation of gene expression; negative regulation of transcription by transcription factor localization; negative regulation of transcription initiation from RNA polymerase II promoter; vascular associated smooth muscle cell development; anterior/posterior axis specification; tricuspid valve formation; negative regulation of transcription, DNA-templated; cardiac ventricle morphogenesis; cardiac right ventricle morphogenesis; ventricular cardiac muscle cell development; atrioventricular valve development; positive regulation of transcription by RNA polymerase II; negative regulation of Notch signaling pathway; cardiac epithelial to mesenchymal transition; Notch signaling involved in heart development; Notch signaling pathway; positive regulation of transcription, DNA-templated; cell differentiation; regulation of neurogenesis; aortic valve morphogenesis; epithelial to mesenchymal transition involved in endocardial cushion formation; positive regulation of gene expression; negative regulation of biomineral tissue development; anterior/posterior pattern specification; circulatory system development;
	Sources:Amigo / QuickGO
Orthologs
	23493
	15214
	ENSG00000135547
	ENSMUSG00000019789
	Q9UBP5; Q5TF93
	Q9QUS4
	NM_012259
	NM_013904
	NP_036391
	NP_038932
	Wikidata
View/Edit Human	View/Edit Mouse

Hairy/enhancer-of-split related with YRPW motif protein 2 (HEY2) also known as cardiovascular helix-loop-helix factor 1 (CHF1) is a protein that in humans is encoded by the HEY2 gene.^[5]^[6]

This protein is a type of transcription factor that belongs to the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcription factors. It forms homo- or hetero-dimers that localize to the nucleus and interact with a histone deacetylase complex to repress transcription. During embryonic development, this mechanism is used to control the number of cells that develop into cardiac progenitor cells and myocardial cells. ^[7] The relationship is inversely related, so as the number of cells that express the Hey2 gene increases, the more CHF1 is present to repress transcription and the number of cells that take on a myocardial fate decreases. ^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000135547 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000019789 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Leimeister C, Externbrink A, Klamt B, Gessler M (July 1999). "Hey genes: a novel subfamily of hairy- and Enhancer of split related genes specifically expressed during mouse embryogenesis". Mechanisms of Development. 85 (1–2): 173–7. doi:10.1016/S0925-4773(99)00080-5. PMID 10415358. S2CID 17342136.
^ "Entrez Gene: HEY2 hairy/enhancer-of-split related with YRPW motif 2".
^ ^a ^b Gibb N, Lazic S, Yuan X, Deshwar AR, Leslie M, Wilson MD, Scott IC (November 2018). "Hey2 regulates the size of the cardiac progenitor pool during vertebrate heart development". Development. 145 (22): dev167510. doi:10.1242/dev.167510. PMID 30355727.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000135547 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000019789 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10415358-5] Leimeister C, Externbrink A, Klamt B, Gessler M (July 1999). "Hey genes: a novel subfamily of hairy- and Enhancer of split related genes specifically expressed during mouse embryogenesis". Mechanisms of Development. 85 (1–2): 173–7. doi:10.1016/S0925-4773(99)00080-5. PMID 10415358. S2CID 17342136.

[entrez-6] "Entrez Gene: HEY2 hairy/enhancer-of-split related with YRPW motif 2".

[emily1-7] Gibb N, Lazic S, Yuan X, Deshwar AR, Leslie M, Wilson MD, Scott IC (November 2018). "Hey2 regulates the size of the cardiac progenitor pool during vertebrate heart development". Development. 145 (22): dev167510. doi:10.1242/dev.167510. PMID 30355727.

HEY2 information

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