Global InformationZona limitans intrathalamica information
The zona limitans intrathalamica (ZLI) is a lineage-restriction compartment and primary developmental boundary in the vertebrate forebrain (which is analogous to the human cerebrum) that serves as a signaling center and a restrictive border between the thalamus (also known as the dorsal thalamus) and the prethalamus (ventral thalamus).
Sonic hedgehog (shh) signaling from the ZLI is crucial in the development of the diencephalon,[1] which develops into the thalamus, the pretectum, and the anterior tegmental structures.[2] The ZLI together with the prethalamus and thalamus make up the mid-diencephalic territory (MDT).[3]
- ^ Scholpp S, Lumsden A (Aug 2010). "Building a bridal chamber: development of the thalamus". Trends Neurosci. 33 (8): 373–380. doi:10.1016/j.tins.2010.05.003. PMC 2954313. PMID 20541814.
- ^ Garcia-Lopez R, Vieira C, Echevarria D, Martinez S (2004). "Fate map of the diencephalon and the zona limitans at 10-somites stage in chick embryos". Developmental Biology. 268 (2): 514–530. doi:10.1016/j.ydbio.2003.12.038. hdl:10261/307883. PMID 15063186.
- ^ Scholpp S, Foucher I, Staudt N, Peukert D, Lumsden A, Houart C (2007). "Otx1l, Otx2, and Irx1b establish and position the ZLI in the diencephalon". Development. 134 (17): 3167–3176. doi:10.1242/dev.001461. PMC 7116068. PMID 17670791.