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Guanosine triphosphate information


Guanosine triphosphate
Skeletal formula of guanosine triphosphate
Space-filling model of the guanosine triphosphate anion
Names
IUPAC name
Guanosine 5′-(tetrahydrogen triphosphate)
Systematic IUPAC name
O1-{[(2R,3S,4R,5R)-5-(2-Amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl} tetrahydrogen triphosphate
Other names
guanosine triphosphate, 9-β-D-ribofuranosylguanine-5'-triphosphate, 9-β-D-ribofuranosyl-2-amino-6-oxo-purine-5'-triphosphate
Identifiers
CAS Number
  • 86-01-1 checkY
3D model (JSmol)
  • Interactive image
ChEBI
  • CHEBI:15996 checkY
ChemSpider
  • 6569 checkY
ECHA InfoCard 100.001.498 Edit this at Wikidata
IUPHAR/BPS
  • 1742
KEGG
  • C00044 ☒N
MeSH Guanosine+triphosphate
PubChem CID
  • 6830
UNII
  • 01WV7J708X checkY
CompTox Dashboard (EPA)
  • DTXSID30235328 Edit this at Wikidata
InChI
  • InChI=1S/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1 checkY
    Key: XKMLYUALXHKNFT-UUOKFMHZSA-N checkY
  • InChI=1/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1
    Key: XKMLYUALXHKNFT-UUOKFMHZBF
SMILES
  • c1nc2c(n1[C@H]3[C@@H]([C@@H]([C@H](O3)CO[P@@](=O)(O)O[P@](=O)(O)OP(=O)(O)O)O)O)[nH]c(nc2=O)N
Properties
Chemical formula
C10H16N5O14P3
Molar mass 523.180 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Guanosine-5'-triphosphate (GTP) is a purine nucleoside triphosphate. It is one of the building blocks needed for the synthesis of RNA during the transcription process. Its structure is similar to that of the guanosine nucleoside, the only difference being that nucleotides like GTP have phosphates on their ribose sugar. GTP has the guanine nucleobase attached to the 1' carbon of the ribose and it has the triphosphate moiety attached to ribose's 5' carbon.

It also has the role of a source of energy or an activator of substrates in metabolic reactions, like that of ATP, but more specific. It is used as a source of energy for protein synthesis and gluconeogenesis.

GTP is essential to signal transduction, in particular with G-proteins, in second-messenger mechanisms where it is converted to guanosine diphosphate (GDP) through the action of GTPases.

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Guanosine triphosphate

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Guanosine-5'-triphosphate (GTP) is a purine nucleoside triphosphate. It is one of the building blocks needed for the synthesis of RNA during the transcription...

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Guanosine

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phosphorylated to become guanosine monophosphate (GMP), cyclic guanosine monophosphate (cGMP), guanosine diphosphate (GDP), and guanosine triphosphate (GTP). These...

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Nucleotide

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nucleoside triphosphates, adenosine triphosphate (ATP), guanosine triphosphate (GTP), cytidine triphosphate (CTP), and uridine triphosphate (UTP)—throughout...

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GTPase

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hydrolase enzymes that bind to the nucleotide guanosine triphosphate (GTP) and hydrolyze it to guanosine diphosphate (GDP). The GTP binding and hydrolysis...

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Cyclic guanosine monophosphate

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Cyclic guanosine monophosphate (cGMP) is a cyclic nucleotide derived from guanosine triphosphate (GTP). cGMP acts as a second messenger much like cyclic...

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Guanosine diphosphate

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DNA Guanosine triphosphate Nucleoside Nucleotide Oligonucleotide RNA Crane, Laura J; Miller, David Lee (1974). "Guanosine triphosphate and guanosine diphosphate...

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Small GTPase

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are a family of hydrolase enzymes that can bind and hydrolyze guanosine triphosphate (GTP). They are a type of G-protein found in the cytosol that are...

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Adenosine triphosphate

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produces two molecules of carbon dioxide, one equivalent of ATP guanosine triphosphate (GTP) through substrate-level phosphorylation catalyzed by succinyl-CoA...

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G protein

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factors that control their ability to bind to and hydrolyze guanosine triphosphate (GTP) to guanosine diphosphate (GDP). When they are bound to GTP, they are...

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GTPgammaS

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(GTPγS, guanosine 5'-O-[gamma-thio]triphosphate) is a non-hydrolyzable or slowly hydrolyzable G-protein-activating analog of guanosine triphosphate (GTP)...

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Deoxyguanosine monophosphate

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forms, respectively, is a derivative of the common nucleic acid guanosine triphosphate (GTP), in which the –OH (hydroxyl) group on the 2' carbon on the...

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GTP cyclohydrolase I

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It is responsible for the hydrolysis of guanosine triphosphate (GTP) to form 7,8-dihydroneopterin triphosphate (7,8-DHNP-3'-TP, 7,8-NH2-3'-TP). GTPCH is...

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Guanylate cyclase

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5′-cyclic-GMP-forming)) is a lyase enzyme that converts guanosine triphosphate (GTP) to cyclic guanosine monophosphate (cGMP) and pyrophosphate: GTP = 3′,5′-cyclic...

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KRAS

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GTPase, a class of enzymes which convert the nucleotide guanosine triphosphate (GTP) into guanosine diphosphate (GDP). In this way the K-Ras protein acts...

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Deoxyguanosine diphosphate

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nucleoside diphosphate. It is related to the common nucleic acid guanosine triphosphate (GTP), with the -OH group on the 2' carbon on the nucleotide's pentose...

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Adenylosuccinate

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phosphoanhydride bond in the form of guanosine triphosphate (GTP). GTP is used instead of adenosine triphosphate (ATP), so the reaction is not dependent...

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Adenylosuccinate synthase

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by catalysing the guanosine triphosphate (GTP)-dependent conversion of inosine monophosphate (IMP) and aspartic acid to guanosine diphosphate (GDP),...

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Guanine nucleotide exchange factor

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monomeric GTPases by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP). A variety of unrelated structural...

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Carbohydrate metabolism

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highly endergonic until it is coupled to the hydrolysis of ATP or guanosine triphosphate (GTP), effectively making the process exergonic. For example, the...

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Ketone body

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brain and muscle, but not the liver. They yield 2 guanosine triphosphate (GTP) and 22 adenosine triphosphate (ATP) molecules per acetoacetate molecule when...

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CGTP

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CGTP may refer to: cyclic guanosine triphosphate Confederación General de Trabajadores de Panamá, the General Confederation of Workers of Panama Confederação...

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Protein splicing

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exogenous cofactors or energy sources such as adenosine triphosphate (ATP) or guanosine triphosphate (GTP). Normally, splicing is associated only with pre-mRNA...

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Biomolecule

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chemical energy (adenosine triphosphate and guanosine triphosphate), participate in cellular signaling (cyclic guanosine monophosphate and cyclic adenosine...

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Guanosine monophosphate

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Guanosine monophosphate (GMP), also known as 5′-guanidylic acid or guanylic acid (conjugate base guanylate), is a nucleotide that is used as a monomer...

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