pteridine-containing compound biosynthetic process
7,8-dihydroneopterin 3'-triphosphate biosynthetic process
dihydrobiopterin metabolic process
regulation of blood pressure
response to tumor necrosis factor
tetrahydrofolate biosynthetic process
response to lipopolysaccharide
positive regulation of nitric-oxide synthase activity
response to pain
tetrahydrobiopterin biosynthetic process
metabolism
protein homooligomerization
regulation of removal of superoxide radicals
positive regulation of heart rate
protein-containing complex assembly
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
2643
14528
Ensembl
ENSG00000131979
ENSMUSG00000037580
UniProt
P30793
Q05915
RefSeq (mRNA)
NM_000161 NM_001024024 NM_001024070 NM_001024071
NM_008102
RefSeq (protein)
NP_000152 NP_001019195 NP_001019241 NP_001019242
NP_032128
Location (UCSC)
Chr 14: 54.84 – 54.9 Mb
Chr 14: 47.39 – 47.43 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
GTP cyclohydrolase I (GTPCH) (EC 3.5.4.16) is a member of the GTP cyclohydrolase family of enzymes. GTPCH is part of the folate and biopterin biosynthesis pathways. It is responsible for the hydrolysis of guanosine triphosphate (GTP) to form 7,8-dihydroneopterin triphosphate (7,8-DHNP-3'-TP, 7,8-NH2-3'-TP).
^ abcGRCh38: Ensembl release 89: ENSG00000131979 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000037580 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
and 19 Related for: GTP cyclohydrolase I information
GTPcyclohydrolaseI (GTPCH) (EC 3.5.4.16) is a member of the GTPcyclohydrolase family of enzymes. GTPCH is part of the folate and biopterin biosynthesis...
toxoflavin. Several GTPcyclohydrolases exist, which sometimes synthesize different products for different pruposes: GTPcyclohydrolaseI, part of the tetrahydrobiopterin...
Autosomal dominant GTPcyclohydrolaseI deficiency (AD-GTPCHD) is a disease caused by dysfunction of GTPcyclohydrolaseI, an enzyme that plays an important...
recessive GTPcyclohydrolaseI deficiency (AR-GTPCHD) is a disorder associated with the deficient operation of the enzyme GTPcyclohydrolaseI. The condition...
Princely Heritage Grey Coat Hospital, a secondary school in London GTPcyclohydrolaseI, an enzyme Gym Class Heroes, an American band Knight Grand Cross...
Sapropterin is indicated in tetrahydrobiopterin deficiency caused by GTPcyclohydrolaseI (GTPCH) deficiency, or 6-pyruvoyltetrahydropterin synthase (PTPS)...
GTPcyclohydrolase 1 feedback regulatory protein is an enzyme that in humans is encoded by the GCHFR gene. GTPcyclohydrolaseI feedback regulatory protein...
in dopamine synthesis and transport: Tyrosine hydroxylase (TH), GTPCyclohydrolaseI (GTPCH), and Vesicular Monoamine Transporter (VMAT) in Drosophila...
Yanofsky C (1992). "The mtrAB operon of Bacillus subtilis encodes GTPcyclohydrolaseI (MtrA), an enzyme involved in folic acid biosynthesis, and MtrB,...
translationally. All known folE RNAs are present upstream of genes encoding GTPcyclohydrolaseI, which performs a step in folate metabolism. folE RNAs have been...
pathway, GTP is converted to 7,8-dihydroneopterin triphosphate by GTPcyclohydrolaseI (GTPCH-1, FolE), which expands the imidazole ring in GTP by one carbon...
Swick L, Kapatos G (2006). "A yeast 2-hybrid analysis of human GTPcyclohydrolaseI protein interactions". J. Neurochem. 97 (5): 1447–55. doi:10.1111/j...
Swick L, Kapatos G (2006). "A yeast 2-hybrid analysis of human GTPcyclohydrolaseI protein interactions". J. Neurochem. 97 (5): 1447–55. doi:10.1111/j...
(1995). "Identification of a rabphilin-3A-interacting protein as GTPcyclohydrolaseI in PC12 cells". Biochem. Biophys. Res. Commun. 205 (2): 1409–16....
occurs in two steps from guanosine triphosphate (GTP). The first being catalyzed by GTPcyclohydrolase, which opens the ribose group. Phosphatases next...
aromatic amino acid dopa decarboxylase, tyrosine hydroxylase and GTP-cyclohydrolase 1, to the striatum in the brain, reprogramming transduced cells to...
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