Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Chemical compound
Cyclic guanosine monophosphate (cGMP) is a cyclic nucleotide derived from guanosine triphosphate (GTP). cGMP acts as a second messenger much like cyclic AMP. Its most likely mechanism of action is activation of intracellular protein kinases in response to the binding of membrane-impermeable peptide hormones to the external cell surface.[1] Through protein kinases activation, cGMP can relax smooth muscle.[2] cGMP concentration in urine can be measured for kidney function and diabetes detection.[3]
^Francis SH, Corbin JD (August 1999). "Cyclic nucleotide-dependent protein kinases: intracellular receptors for cAMP and cGMP action". Critical Reviews in Clinical Laboratory Sciences. 36 (4): 275–328. doi:10.1080/10408369991239213. PMID 10486703.
^Chaykovska L, Heunisch F, von Einem G, Hocher CF, Tsuprykov O, Pavkovic M, et al. (2018-04-12). Shimosawa T (ed.). "Urinary cGMP predicts major adverse renal events in patients with mild renal impairment and/or diabetes mellitus before exposure to contrast medium". PLOS ONE. 13 (4): e0195828. Bibcode:2018PLoSO..1395828C. doi:10.1371/journal.pone.0195828. PMC 5896998. PMID 29649334.
and 24 Related for: Cyclic guanosine monophosphate information
Cyclicguanosinemonophosphate (cGMP) is a cyclic nucleotide derived from guanosine triphosphate (GTP). cGMP acts as a second messenger much like cyclic...
Cyclic adenosine monophosphate (cAMP, cyclic AMP, or 3',5'-cyclic adenosine monophosphate) is a second messenger, or cellular signal occurring within...
can be seen in the cyclic adenosine monophosphate (cAMP) and cyclicguanosinemonophosphate (cGMP) images, the 'cyclic' portion consists of two bonds between...
phosphorylated to become guanosinemonophosphate (GMP), cyclicguanosinemonophosphate (cGMP), guanosine diphosphate (GDP), and guanosine triphosphate (GTP)...
nucleotides participate in cell signaling (cyclicguanosinemonophosphate or cGMP and cyclic adenosine monophosphate or cAMP) and are incorporated into important...
inhibitor of guanosinemonophosphate synthesis in experimental models, the glutamine analogue DON can be used. GMP can also exist as a cyclic structure known...
(cyclizing; 3′,5′-cyclic-GMP-forming)) is a lyase enzyme that converts guanosine triphosphate (GTP) to cyclicguanosinemonophosphate (cGMP) and pyrophosphate:...
of the intracellular second messengers, cyclic adenosine monophosphate (cAMP) and cyclicguanosinemonophosphate (cGMP) by the respective PDE subtype(s)...
Natriuretic Peptide Receptor-C (NPR-C). NPR-A and NPR-B use cyclicguanosinemonophosphate (cGMP) as its intracellular messenger. NPR-A binds selectively...
activates phosphodiesterase, which results in the breakdown of cyclicguanosinemonophosphate (cGMP). The intensity of the flash response is directly proportional...
vivo. IMPDH is a rate limiting enzyme that catalyses IMP to xanthosine monophosphate (XMP). It can induce meiotic resumption as XMP produced is ultimately...
endothelial cells, which stimulates the synthesis of cyclicguanosinemonophosphate (more commonly known as cyclic GMP or cGMP) in smooth muscle cells.[medical...
action is thought to be via the inhibition of the nitric oxide-cyclicguanosinemonophosphate pathway. This pathway is excessively activated in septic shock...
pfizer.com. Retrieved 1 August 2019. Murad F (July 1986). "CyclicGuanosineMonophosphate as a Mediator of Vasodilation". J. Clin. Investig. 78 (1): 1–5...
triphosphate and guanosine triphosphate), participate in cellular signaling (cyclicguanosinemonophosphate and cyclic adenosine monophosphate), and are incorporated...
activates soluble guanylate cyclase which converts guanosine triphosphate (GTP) to cyclicguanosinemonophosphate (cGMP), the main effector of the system. For...
counterregulation of the renin–angiotensin–aldosterone system, stimulating cyclicguanosinemonophosphate, leading to smooth muscle cell relaxation. Nesiritide was believed...
CGMP is an initialism. It can refer to: cyclicguanosinemonophosphate (cGMP) current good manufacturing practice (cGMP) CGMP, Cisco Group Management Protocol...
circulation at therapeutic doses. Activation of GC-C increases cyclicguanosinemonophosphate (cGMP). Elevated cGMP stimulates secretion of chloride and bicarbonate...
specificity for subtypes, and therefore promotes the degradation of cyclicguanosinemonophosphate (cGMP), resulting in a decreased intracellular concentration...
intracellular second messengers such as cyclic adenine monophosphate (cAMP) and cyclicguanosinemonophosphate (cGMP) which leads to several biological...
without CNGB3. One such alteration is decreased affinity for Cyclicguanosinemonophosphate. Others include the introduction of a sub-conductance, altered...
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