Gonadotropin secretion (follicle-stimulating hormone (FSH) and luteinizing hormone (LH))
Identifiers
MeSH
D052681
TH
H3.08.02.2.00004
FMA
83100
Anatomical terms of microanatomy
[edit on Wikidata]
Gonadotropic cells (called also gonadotropes, gonadotrophs, delta cells or delta basophils)[1] are endocrine cells in the anterior pituitary that produce the gonadotropins, such as the follicle-stimulating hormone (FSH) and luteinizing hormone (LH). Release of FSH and LH by gonadotropes is regulated by gonadotropin-releasing hormone (GnRH) from the hypothalamus.[2]
Gonadotropes appear basophilic in histological preparations.
Gonadotropes have insulin receptors, which can be overstimulated by too high insulin levels. This may lead to infertility as hormone release levels are disrupted.[3][4]
Gonadotropes are feedback inhibited by specific hormones, including estradiol.[5]
^DOUGLAS, ANDERSON (2012). Dorland's Illustrated Medical Dictionary, 32 edition. USA: Elsevier. p. 797. ISBN 978-1-4160-6257-8.
^Ganong, William F.: "Review of Medical Physiology", page 248. Lange, 2005.
^Brothers, K. J.; Wu, S.; Divall, S. A.; Messmer, M. R.; Kahn, C. R.; Miller, R. S.; Radovick, S.; Wondisford, F. E.; Wolfe, A. (2010). "Rescue of Obesity-Induced Infertility in Female Mice due to a Pituitary-Specific Knockout of the Insulin Receptor (IR)". Cell Metabolism. 12 (3): 295–305. doi:10.1016/j.cmet.2010.06.010. PMC 2935812. PMID 20816095.
^Hill JW, Elias CF, Fukuda M, Williams KW, Berglund ED, Holland WL, Cho YR, Chuang JC, Xu Y, Choi M, Lauzon D, Lee CE, Coppari R, Richardson JA, Zigman JM, Chua S, Scherer PE, Lowell BB, Brüning JC, Elmquist JK (2010). "Direct insulin and leptin action on pro-opiomelanocortin neurons is required for normal glucose homeostasis and fertility". Cell Metabolism. 11 (4): 286–97. doi:10.1016/j.cmet.2010.03.002. PMC 2854520. PMID 20374961.
^Iqbal, Javed; Latchoumanin, Olivier; Sari, Ika P.; Lang, Richard J.; Coleman, Harold A.; Parkington, Helena C.; Clarke, Iain J. (2009-09-01). "Estradiol-17beta inhibits gonadotropin-releasing hormone-induced Ca2+ in gonadotropes to regulate negative feedback on luteinizing hormone release". Endocrinology. 150 (9): 4213–4220. doi:10.1210/en.2009-0092. ISSN 1945-7170. PMID 19477939.
Gonadotropiccells (called also gonadotropes, gonadotrophs, delta cells or delta basophils) are endocrine cells in the anterior pituitary that produce...
Gonadotropins are glycoprotein hormones secreted by gonadotropiccells of the anterior pituitary of vertebrates. This family includes the mammalian hormones...
hormone, lutropin and sometimes lutrophin) is a hormone produced by gonadotropiccells in the anterior pituitary gland. The production of LH is regulated...
Pituitary gland Somatotropic cell Lactotropic cell Somatomammotropic cellGonadotropiccell Thyrotropic cell List of distinct cell types in the adult human...
Follicular cells are flat epithelial cells that originate from surface epithelium covering the ovary. They are surrounded by granulosa cells that have...
axis). Hypothalamic disorders result from a deficiency in the release of gonadotropic releasing hormone (GnRH), while pituitary gland disorders are due to...
Complications in Thalassemia 1) Hypogonadism: iron overload in pituitary gonadotropiccells causes decreased gonadotrophin secretion which leads to delayed, slow...
e.g. hot flushes, vagina dryness. This is because the pituitary gonadotropiccells are desensitized , i.e. the number of receptors have reduced. Whereas...
effect of testicular shrinkage. Stimulation of testicular functions via gonadotropic-like hormones may enlarge their size. Testes may shrink or atrophy during...
toads generate spermatozoa after long contact with female frogs, the gonadotropic hormone would be secreted from the females' bodies. He realized the female...
luteinizing hormone (LH), and follicle stimulating hormone (FSH). These gonadotropic hormones lead to sexual maturation and gametogenesis. Disrupting GPR54...
hypothalamus and the hypothalamus then controls sexual behavior and desire. Gonadotropic hormones in Drosophila maintain homeostasis and govern reproductive output...
can influence gene expression in particular neurons or induce changes in cell membrane potential and kinase activation, leading to diverse non-genomic...
normal pituitary gland. They include thyroid stimulating hormone (TSH), gonadotropic hormones (FSH, LH), adrenocorticotropic hormone, and prolactin.[citation...
studies. Hypogonadism can be differentiated between hyper- and hypo-gonadotropic hypogonadism by measuring serum follicle-stimulating hormone (FSH) and...
reduce testosterone production via testicular atrophy and inhibition of gonadotropic activity. Unlike some AASs, oxandrolone does not generally cause gynecomastia...
lumbar puncture, which can show fluid-to-serum ratio of human chorionic gonadotropic and reflect whether the disease has potentially spread to the central...
a weak luteotropic effect while the effect of suppressing classical gonadotropic hormones is more important. Prolactin within the normal reference ranges...
Retrieved 27 April 2023. Friedman, Maurice (1 May 1939). "The Assay of Gonadotropic Extracts in the Post-Partum Rabbit11". Endocrinology. 24 (5): 617–625...
American English, or "on heat" in British English). Under regulation by gonadotropic hormones, ovarian follicles mature and estrogen secretions exert their...
306–12. PMID 5188348. Gustavo RP (July 1958). "[Anti-gonadotropic action of possipione]" [Anti-gonadotropic action of possipione]. Quaderni di Clinica Ostetrica...
possessing strong progestational, moderate anti-androgenic and limited anti-gonadotropic potencies. [...] Its progestational activity, in terms of the transformation...
cause FHA in normal weight patients who present no abnormal metabolic or gonadotropic laboratory results. In these cases, combined hormonal contraceptive pills...
target for regulation by insulin, and introduced a new paradigm for the gonadotropic function of insulin. Poretsky had been researching the causes of hyperandrogenism...
early 20th century, artificial insemination projects in the 1930s, and gonadotropic hormone studies in the 1940s. List of National Historic Landmarks in...
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