negative regulation of cell population proliferation
positive regulation of synaptic transmission
positive regulation of MAPK cascade
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway
positive regulation of luteinizing hormone secretion
positive regulation of cytosolic calcium ion concentration
positive regulation of growth hormone secretion
cytoskeleton organization
generation of ovulation cycle rhythm
G protein-coupled receptor signaling pathway
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
3814
280287
Ensembl
ENSG00000170498
ENSMUSG00000116158
UniProt
Q15726
Q6Y4S4
RefSeq (mRNA)
NM_002256
NM_178260
RefSeq (protein)
NP_002247
NP_839991
Location (UCSC)
Chr 1: 204.19 – 204.2 Mb
Chr 1: 133.25 – 133.26 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Kisspeptins (including kisspeptin-54 (KP-54), formerly known as metastin) are proteins encoded by the KISS1 gene in humans. Kisspeptins are ligands of the G-protein coupled receptor, GPR54.[5]Kiss1 was originally identified as a human metastasis suppressor gene that has the ability to suppress melanoma and breast cancer metastasis.[6] Kisspeptin-GPR54 signaling has an important role in initiating secretion of gonadotropin-releasing hormone (GnRH) at puberty, the extent of which is an area of ongoing research.[7] Gonadotropin-releasing hormone is released from the hypothalamus to act on the anterior pituitary triggering the release of luteinizing hormone (LH), and follicle stimulating hormone (FSH). These gonadotropic hormones lead to sexual maturation and gametogenesis. Disrupting GPR54 signaling can cause hypogonadotrophic hypogonadism in rodents and humans. The Kiss1 gene is located on chromosome 1. It is transcribed in the brain, adrenal gland, and pancreas.
^ abcGRCh38: Ensembl release 89: ENSG00000170498 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000116158 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Messager S, Chatzidaki EE, Ma D, Hendrick AG, Zahn D, Dixon J, Thresher RR, Malinge I, Lomet D, Carlton MB, Colledge WH, Caraty A, Aparicio SA (February 2005). "Kisspeptin directly stimulates gonadotropin-releasing hormone release via G protein-coupled receptor 54". Proceedings of the National Academy of Sciences of the United States of America. 102 (5): 1761–6. Bibcode:2005PNAS..102.1761M. doi:10.1073/pnas.0409330102. PMC 545088. PMID 15665093.
^Lee JH, Miele ME, Hicks DJ, Phillips KK, Trent JM, Weissman BE, Welch DR (December 1996). "KiSS-1, a novel human malignant melanoma metastasis-suppressor gene". Journal of the National Cancer Institute. 88 (23): 1731–7. doi:10.1093/jnci/88.23.1731. PMID 8944003.
^Skorupskaite K, George JT, Anderson RA (2014). "The kisspeptin-GnRH pathway in human reproductive health and disease". Human Reproduction Update. 20 (4): 485–500. doi:10.1093/humupd/dmu009. PMC 4063702. PMID 24615662.
Kisspeptins (including kisspeptin-54 (KP-54), formerly known as metastin) are proteins encoded by the KISS1 gene in humans. Kisspeptins are ligands of...
levels of both neurokinin B and also the G-protein coupled receptor ligand kisspeptin. The first NKB studies done attempted to resolve why high levels of the...
Kisspeptin, neurokinin B, and dynorphin (KNDy) neurons are neurons in the hypothalamus of the brain that are central to the hormonal control of reproduction...
hypogonadism (nHH) hypothalamic hypogonadism olfacto-genital syndrome Kisspeptin is a protein that regulates the release of GnRH from the hypothalamus...
decrease the stimulation of insulin which in turn does not stimulate kisspeptin neurons, vital in the release of puberty-starting hormones. This shows...
pre-pubertal growth and a significant delay in puberty onset. Mutations in the kisspeptin (KISS1) and its receptor, KISS1R (also known as GPR54), involved in GnRH...
reproduction. The strongest activator of GnRH neurons is a hormone called Kisspeptin. GnRH neurons also integrate information from the body through hormones...
of GnRH. GnRH neurons lack sex steroid receptors and mediators such as kisspeptin stimulate GnRH neurons for pulsatile secretion of GnRH. There are two...
development PTP4A2, protein tyrosine phosphatase type IVA 2, also called "HH13" Kisspeptin (HH13) Search for "hh13" or "hh-13" on Wikipedia. All pages with titles...
midcycle surge of LH that stimulates ovulation. Although estrogens inhibit kisspeptin (Kp) release from kiss1 neurons in the ARC, estrogens stimulate Kp release...
hypothesized that neurokinin B might play a role in regulating the secretion of kisspeptin, a compound responsible for triggering direct release of GnRH as well...
also influenced by release of the protein kisspeptin at the time of gonadarche onset. The production of kisspeptin mediates the GnRH pulse release in puberty...
hypothalamus and involve complex interplay between the neurotransmitters kisspeptin, neurokinin B, and dynorphin, which are found in KNDy neurons in the infundibular...
Iron–sulfur cluster Jipitol K252a K252b KT5720 KT5823 Keratin Kinase Kisspeptin Kouhestanimine For substances with an l- or L- prefix such as L-alanine...
periventricular region of the third ventricle (RP3V). This area is full of kisspeptin-expressing neurons and is involved in regulating GnRH neurons, and is...
Global Information
