Chemical compound
Gefapixant Trade names Lyfnua Other names MK-7264 ATC code Legal status
5-(2,4-diaminopyrimidin-5-yl)oxy-2-methoxy-4-propan-2-ylbenzenesulfonamide
CAS Number PubChem CID DrugBank ChemSpider UNII KEGG ChEMBL CompTox Dashboard (EPA ) DTXSID401337212 ECHA InfoCard 100.258.106 Formula C 14 H 19 N 5 O 4 S Molar mass 353.40 g·mol−1 3D model (JSmol)
CC(C)C1=CC(=C(C=C1OC2=CN=C(N=C2N)N)S(=O)(=O)N)OC
InChI=1S/C14H19N5O4S/c1-7(2)8-4-10(22-3)12(24(17,20)21)5-9(8)23-11-6-18-14(16)19-13(11)15/h4-7H,1-3H3,(H2,17,20,21)(H4,15,16,18,19)
Key:HLWURFKMDLAKOD-UHFFFAOYSA-N
Gefapixant , sold under the brand name Lyfnua , is a medication used to treat chronic (long-term) cough.[1] It acts as an antagonist of the P2RX3 receptor.[2] [3] [4]
It was approved for medical use in the European Union in September 2023.[1]
^ a b c "Lyfnua EPAR". European Medicines Agency . 29 September 2023. Retrieved 5 October 2023 .
^ Muccino D, Green S (June 2019). "Update on the clinical development of gefapixant, a P2X3 receptor antagonist for the treatment of refractory chronic cough". Pulmonary Pharmacology & Therapeutics . 56 : 75–78. doi:10.1016/j.pupt.2019.03.006. PMID 30880151. S2CID 81982653.
^ Richards D, Gever JR, Ford AP, Fountain SJ (July 2019). "Action of MK-7264 (gefapixant) at human P2X3 and P2X2/3 receptors and in vivo efficacy in models of sensitisation". British Journal of Pharmacology . 176 (13): 2279–2291. doi:10.1111/bph.14677. PMC 6555852 . PMID 30927255.
^ Marucci G, Dal Ben D, Buccioni M, Martí Navia A, Spinaci A, Volpini R, et al. (December 2019). "Update on novel purinergic P2X3 and P2X2/3 receptor antagonists and their potential therapeutic applications". Expert Opinion on Therapeutic Patents . 29 (12): 943–963. doi:10.1080/13543776.2019.1693542. hdl:11581/435751 . PMID 31726893. S2CID 208037373.
Last Update: 2023-12-20T19:49:35Z
Gefapixant , sold under the brand name Lyfnua, is a medication used to treat chronic (long-term) cough. It acts as an antagonist of the P2RX3 receptor....
Word Count : 251
Last Update: 2024-04-21T09:16:57Z
Calmidazolium Chelerythrine Copper Emodin (Rheum officinale) Evans blue Gefapixant GW-791343 HMA Ip5I isoPPADS JNJ-47965567 KN-04 KN-62 Magnesium MRS-2159...
Word Count : 3112
Last Update: 2024-02-06T13:01:04Z
Calmidazolium Chelerythrine Copper Emodin (Rheum officinale) Evans blue Gefapixant GW-791343 HMA Ip5I isoPPADS JNJ-47965567 KN-04 KN-62 Magnesium MRS-2159...
Word Count : 2510
Last Update: 2024-05-21T20:23:44Z
Calmidazolium Chelerythrine Copper Emodin (Rheum officinale) Evans blue Gefapixant GW-791343 HMA Ip5I isoPPADS JNJ-47965567 KN-04 KN-62 Magnesium MRS-2159...
Word Count : 903
Last Update: 2022-05-02T10:11:47Z
R05DB26 Nepinalone R05DB27 Levodropropizine R05DB28 Dimethoxanate R05DB29 Gefapixant R05FA01 Opium derivatives and mucolytics R05FA02 Opium derivatives and...
Word Count : 362
Last Update: 2024-05-06T22:21:32Z
Calmidazolium Chelerythrine Copper Emodin (Rheum officinale) Evans blue Gefapixant GW-791343 HMA Ip5I isoPPADS JNJ-47965567 KN-04 KN-62 Magnesium MRS-2159...
Word Count : 3299
Last Update: 2024-06-08T21:42:07Z
Calmidazolium Chelerythrine Copper Emodin (Rheum officinale) Evans blue Gefapixant GW-791343 HMA Ip5I isoPPADS JNJ-47965567 KN-04 KN-62 Magnesium MRS-2159...
Word Count : 1809
Last Update: 2024-05-28T13:43:45Z
Calmidazolium Chelerythrine Copper Emodin (Rheum officinale) Evans blue Gefapixant GW-791343 HMA Ip5I isoPPADS JNJ-47965567 KN-04 KN-62 Magnesium MRS-2159...
Word Count : 4633
Last Update: 2024-05-16T17:54:00Z
Calmidazolium Chelerythrine Copper Emodin (Rheum officinale) Evans blue Gefapixant GW-791343 HMA Ip5I isoPPADS JNJ-47965567 KN-04 KN-62 Magnesium MRS-2159...
Word Count : 2755
Last Update: 2024-06-10T08:28:46Z
Calmidazolium Chelerythrine Copper Emodin (Rheum officinale) Evans blue Gefapixant GW-791343 HMA Ip5I isoPPADS JNJ-47965567 KN-04 KN-62 Magnesium MRS-2159...
Word Count : 3692
Last Update: 2024-05-19T06:09:30Z
Calmidazolium Chelerythrine Copper Emodin (Rheum officinale) Evans blue Gefapixant GW-791343 HMA Ip5I isoPPADS JNJ-47965567 KN-04 KN-62 Magnesium MRS-2159...
Word Count : 1818
Last Update: 2024-06-02T00:36:00Z
Calmidazolium Chelerythrine Copper Emodin (Rheum officinale) Evans blue Gefapixant GW-791343 HMA Ip5I isoPPADS JNJ-47965567 KN-04 KN-62 Magnesium MRS-2159...
Word Count : 19821
Last Update: 2024-06-08T07:20:26Z
Calmidazolium Chelerythrine Copper Emodin (Rheum officinale) Evans blue Gefapixant GW-791343 HMA Ip5I isoPPADS JNJ-47965567 KN-04 KN-62 Magnesium MRS-2159...
Word Count : 3949
Last Update: 2024-05-19T10:46:46Z
Calmidazolium Chelerythrine Copper Emodin (Rheum officinale) Evans blue Gefapixant GW-791343 HMA Ip5I isoPPADS JNJ-47965567 KN-04 KN-62 Magnesium MRS-2159...
Word Count : 3103
Last Update: 2023-12-29T09:16:13Z
Calmidazolium Chelerythrine Copper Emodin (Rheum officinale) Evans blue Gefapixant GW-791343 HMA Ip5I isoPPADS JNJ-47965567 KN-04 KN-62 Magnesium MRS-2159...
Word Count : 1501
Last Update: 2024-02-24T17:44:24Z
Calmidazolium Chelerythrine Copper Emodin (Rheum officinale) Evans blue Gefapixant GW-791343 HMA Ip5I isoPPADS JNJ-47965567 KN-04 KN-62 Magnesium MRS-2159...
Word Count : 1523
Last Update: 2024-06-01T14:05:15Z
Calmidazolium Chelerythrine Copper Emodin (Rheum officinale) Evans blue Gefapixant GW-791343 HMA Ip5I isoPPADS JNJ-47965567 KN-04 KN-62 Magnesium MRS-2159...
Word Count : 7752
Last Update: 2023-12-01T01:58:08Z
Calmidazolium Chelerythrine Copper Emodin (Rheum officinale) Evans blue Gefapixant GW-791343 HMA Ip5I isoPPADS JNJ-47965567 KN-04 KN-62 Magnesium MRS-2159...
Word Count : 851
Last Update: 2024-06-05T22:10:18Z
Calmidazolium Chelerythrine Copper Emodin (Rheum officinale) Evans blue Gefapixant GW-791343 HMA Ip5I isoPPADS JNJ-47965567 KN-04 KN-62 Magnesium MRS-2159...
Word Count : 2467
Last Update: 2023-04-30T17:01:03Z
Calmidazolium Chelerythrine Copper Emodin (Rheum officinale) Evans blue Gefapixant GW-791343 HMA Ip5I isoPPADS JNJ-47965567 KN-04 KN-62 Magnesium MRS-2159...
Word Count : 144
Last Update: 2024-05-28T03:02:42Z
Calmidazolium Chelerythrine Copper Emodin (Rheum officinale) Evans blue Gefapixant GW-791343 HMA Ip5I isoPPADS JNJ-47965567 KN-04 KN-62 Magnesium MRS-2159...
Word Count : 2237
Last Update: 2024-05-11T11:13:47Z
Calmidazolium Chelerythrine Copper Emodin (Rheum officinale) Evans blue Gefapixant GW-791343 HMA Ip5I isoPPADS JNJ-47965567 KN-04 KN-62 Magnesium MRS-2159...
Word Count : 1208
Last Update: 2024-05-27T16:32:15Z
Calmidazolium Chelerythrine Copper Emodin (Rheum officinale) Evans blue Gefapixant GW-791343 HMA Ip5I isoPPADS JNJ-47965567 KN-04 KN-62 Magnesium MRS-2159...
Word Count : 967
Last Update: 2024-05-28T13:40:20Z
Calmidazolium Chelerythrine Copper Emodin (Rheum officinale) Evans blue Gefapixant GW-791343 HMA Ip5I isoPPADS JNJ-47965567 KN-04 KN-62 Magnesium MRS-2159...
Word Count : 2233
Last Update: 2024-03-03T05:12:28Z
Calmidazolium Chelerythrine Copper Emodin (Rheum officinale) Evans blue Gefapixant GW-791343 HMA Ip5I isoPPADS JNJ-47965567 KN-04 KN-62 Magnesium MRS-2159...
Word Count : 487
Last Update: 2024-02-05T04:35:38Z
Calmidazolium Chelerythrine Copper Emodin (Rheum officinale) Evans blue Gefapixant GW-791343 HMA Ip5I isoPPADS JNJ-47965567 KN-04 KN-62 Magnesium MRS-2159...
Word Count : 1088
Last Update: 2023-12-25T06:19:25Z
Calmidazolium Chelerythrine Copper Emodin (Rheum officinale) Evans blue Gefapixant GW-791343 HMA Ip5I isoPPADS JNJ-47965567 KN-04 KN-62 Magnesium MRS-2159...
Word Count : 953
Last Update: 2024-06-03T06:14:26Z
Calmidazolium Chelerythrine Copper Emodin (Rheum officinale) Evans blue Gefapixant GW-791343 HMA Ip5I isoPPADS JNJ-47965567 KN-04 KN-62 Magnesium MRS-2159...
Word Count : 3186