Glc_transpt_3IPR002945GLUT3Glucose transporter type 3brainGlut-3
External IDs
GeneCards: [1]; OMA:- orthologs
Orthologs
Species
Human
Mouse
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Ensembl
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UniProt
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RefSeq (mRNA)
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RefSeq (protein)
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Location (UCSC)
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Wikidata
View/Edit Human
Glucose transporter 3 (or GLUT3), also known as solute carrier family 2, facilitated glucose transporter member 3 (SLC2A3) is a protein that in humans is encoded by the SLC2A3 gene.[1] GLUT3 facilitates the transport of glucose across the plasma membranes of mammalian cells. GLUT3 is most known for its specific expression in neurons and has originally been designated as the neuronal GLUT. GLUT3 has been studied in other cell types with specific glucose requirements, including sperm, preimplantation embryos, circulating white blood cells and carcinoma cell lines.[2]
^Kayano T, Fukumoto H, Eddy RL, Fan YS, Byers MG, Shows TB, Bell GI (October 1988). "Evidence for a family of human glucose transporter-like proteins. Sequence and gene localization of a protein expressed in fetal skeletal muscle and other tissues". J Biol Chem. 263 (30): 15245–8. doi:10.1016/S0021-9258(19)37577-5. PMID 3170580.
^Simpson IA, Dwyer D, Malide D, Moley KH, Travis A, Vannucci SJ (August 2008). "The facilitative glucose transporter GLUT3: 20 years of distinction". Am. J. Physiol. Endocrinol. Metab. 295 (2): E242–53. doi:10.1152/ajpendo.90388.2008. PMC 2519757. PMID 18577699.
Glucose transporter 3 (or GLUT3), also known as solute carrier family 2, facilitated glucose transporter member 3 (SLC2A3) is a protein that in humans...
Km value suggests a high affinity) of the GLUT1 and GLUT3 proteins is 1mM; therefore GLUT1 and GLUT3 have a high affinity for glucose and uptake from the...
ascorbate across plasma membranes. The Hexose Transporter proteins GLUT1, GLUT3 and GLUT4 transfer only the oxydized dehydroascorbic acid (DHA) form of...
portal circulation by GLUT2. Is a high-frequency and low-affinity isoform. GLUT3 Expressed mostly in neurons (where it is believed to be the main glucose...
pancreatic β cell (Primary in mice, tertiary in humans after GLUT1 and GLUT3) hypothalamus (Not overly significant) basolateral membrane of small intestine...
and is of particular importance for nerve cells and pancreatic β-cells. GLUT3 is highly expressed in nerve cells. Glucose from the bloodstream is taken...
"Hypoxia inducible factor-1 and facilitative glucose transporters GLUT1 and GLUT3: putative molecular components of the oxygen and glucose sensing apparatus...
insulin secretion from pancreatic beta cells. Class II includes the GLUT3 and GLUT4. GLUT3, primarily found in the brain, neurons and placenta, has a high...
syncytiotrophoblast glucose transporters with advancing gestation. Finally, the role of GLUT3/GLUT4 transport remains speculative. If the untreated gestational diabetes...
Retrieved 2011-10-23. Wu X, Freeze HH (December 2002). "GLUT14, a duplicon of GLUT3, is specifically expressed in testis as alternative splice forms". Genomics...
"Hypoxia inducible factor-1 and facilitative glucose transporters GLUT1 and GLUT3: putative molecular components of the oxygen and glucose sensing apparatus...
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