Cotransporters are a subcategory of membrane transport proteins (transporters) that couple the favorable movement of one molecule with its concentration gradient and unfavorable movement of another molecule against its concentration gradient. They enable coupled or cotransport (secondary active transport) and include antiporters and symporters. In general, cotransporters consist of two out of the three classes of integral membrane proteins known as transporters that move molecules and ions across biomembranes. Uniporters are also transporters but move only one type of molecule down its concentration gradient and are not classified as cotransporters.[1]
Basic difference between the cotransporters known as antiporters and symporters, and the uniporter transporter.
^Lodish, Harvey; Berk, A.; Amon, A.; Bretscher, A.; Kaiser, C.; Kriefer, M.; et al. (2013). Molecular cell biology (7th ed.). New York: W.H. Freeman and Co. ISBN 978-1-4292-3413-9.
Cotransporters are a subcategory of membrane transport proteins (transporters) that couple the favorable movement of one molecule with its concentration...
therefore lower blood sugar. They act by inhibiting sodium/glucose cotransporter 2 (SGLT2). SGLT2 inhibitors are used in the treatment of type 2 diabetes...
gene. The SLC12A3 gene encodes the thiazide-sensitive sodium-chloride cotransporter (also known as NCC, NCCT, or TSC), which can be found in the distal...
following proteins: Mammalian sodium/sulphate cotransporter. Mammalian renal sodium/dicarboxylate cotransporter, which transports succinate and citrate. Mammalian...
Electrogenic sodium bicarbonate cotransporter 1, sodium bicarbonate cotransporter is a membrane transport protein that in humans is encoded by the SLC4A4...
bicarbonate cotransporter 4 is a protein that in humans is encoded by the SLC4A5 gene. This gene encodes a member of the sodium bicarbonate cotransporter (NBC)...
range of molecules and ions into virtually every cell type. Cotransport Cotransporter GLUT1 deficiency syndrome GLUT2 deficiency syndrome Maier A, Völker...
medication used for the treatment of cats. Velagliflozin is a sodium-glucose cotransporter 2 (SGLT2) inhibitor. It is taken by mouth. Velagliflozin is indicated...
diuretics are pharmacological agents that primarily inhibit the Na-K-Cl cotransporter located on the luminal membrane of cells along the thick ascending limb...
"Dose-dependent glucosuria of DWP16001, a novel selective sodium–glucose cotransporter-2 inhibitor, in healthy subjects". British Journal of Clinical Pharmacology...
Sodium bicarbonate cotransporter 3 is a protein which in humans is encoded by the SLC4A7 gene. Solute carrier family GRCh38: Ensembl release 89: ENSG00000033867...
surface (lumen side), cells of the DCT have a thiazide-sensitive Na-Cl cotransporter and are permeable to Ca, via the TRPV5 channel. On the basolateral surface...
One category of cotransporters that is especially prominent in research regarding diabetes treatment is sodium-glucose cotransporters. These transporters...
across the cell membrane at the same time, and is, therefore, a type of cotransporter. The transporter is called a symporter, because the molecules will travel...
Na-dependent inorganic phosphate cotransporter and they appear to form a distinct class within the Na+/Pi cotransporter family. Solute carrier family GRCh38:...
In the field of neurology, temporal lobe epilepsy is an enduring brain disorder that causes unprovoked seizures from the temporal lobe. Temporal lobe epilepsy...
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