Protein created by joining other proteins into a single polypeptide
This article is about chimeric fusion proteins. For proteins involved in membrane fusion, see membrane fusion protein.
A chimeric protein including two subunits and a linker protein synthesized via recombinant fusion technology
Fusion proteins or chimeric (kī-ˈmir-ik) proteins (literally, made of parts from different sources) are proteins created through the joining of two or more genes that originally coded for separate proteins. Translation of this fusion gene results in a single or multiple polypeptides with functional properties derived from each of the original proteins. Recombinant fusion proteins are created artificially by recombinant DNA technology for use in biological research or therapeutics. Chimeric or chimera usually designate hybrid proteins made of polypeptides having different functions or physico-chemical patterns. Chimeric mutant proteins occur naturally when a complex mutation, such as a chromosomal translocation, tandem duplication, or retrotransposition creates a novel coding sequence containing parts of the coding sequences from two different genes. Naturally occurring fusion proteins are commonly found in cancer cells, where they may function as oncoproteins. The bcr-abl fusion protein is a well-known example of an oncogenic fusion protein, and is considered to be the primary oncogenic driver of chronic myelogenous leukemia.
Fusionproteins or chimeric (kī-ˈmir-ik) proteins (literally, made of parts from different sources) are proteins created through the joining of two or...
protein also alters host immune response by inhibiting signaling from several toll-like receptors, including TLR4. Surface protein F (fusionprotein)...
membrane fusionproteins. An example of a Class III viral fusionprotein is the rabies virus glycoprotein, G. Class IV: Class IV viral fusionproteins are...
Membrane fusionproteins (not to be confused with chimeric or fusionproteins) are proteins that cause fusion of biological membranes. Membrane fusion is critical...
gene encodes for a BCR-ABL1 fusionprotein. Depending on the precise location of fusion, the molecular weight of this protein can range from 185 to 210...
proteins. The membrane fusion event that triggers viral entrance is caused by the viral fusionprotein. Many enveloped viruses only have one protein visible...
fusing the viral and cellular membranes. Spike glycoprotein is a class I fusionprotein that contains two regions, known as S1 and S2, responsible for these...
Next in the cycle is the fusion of the viral and host membranes which is likely mediated by the F protein. Though the fusion mechanism is very similar...
cells. For example, by creating a fusion gene of a protein of interest and green fluorescent protein, the protein of interest may be observed in cells...
against a GST-fusionprotein it will produce antibodies against the fusion-protein, and possibly antibodies against the GST tag as well. The protein can then...
Coronaviruses exhibit coronavirus spike protein, also known as the S protein, on their surfaces; S is a class I fusionprotein and is responsible for mediating...
SNARE proteins is to mediate the fusion of vesicles with the target membrane; this notably mediates exocytosis, but can also mediate the fusion of vesicles...
getting rid of undesirable fusionproteins such as AML1-ETO. In a 2013 study, scientists demonstrated that the degradation of fusion oncoprotein AML1-ETO is...
allows the fusionprotein to access and activate micro-satellite regions of the genome that would otherwise be inaccessible. This fusionprotein can convert...
fusionprotein has been expressed, there is a wide range of potential areas of experimentation including enzymatic assays, cellular imaging, protein arrays...
chromosomes, one of each pair "sticks" and blends together homogeneously. A gene fusion may be created when the translocation joins two otherwise-separated genes...
various diseases are given in the table below. Receptor constructs (fusionproteins), usually based on a naturally occurring receptor linked to the immunoglobulin...
writes new genetic information into a targeted DNA site. It uses a fusionprotein, consisting of a catalytically impaired Cas9 endonuclease fused to an...
as OPA1 in mammals mediates fusion between mitochondrial inner membranes. These regulating proteins of mitochondrial fusion are organism-dependent; therefore...
of nuclei. The work conducted by Henry and Nils showed that proteins from one gene fusion affect gene expression in the other partner's nucleus, and vice...
express the proteins of interest, the construct must be able to express proteins that are able to form fusionproteins with fluorescent protein fragments...
notable exceptions due to a unique set of proteins known as fusion-associated small transmembrane (FAST) proteins. Reovirus induced syncytium formation is...
IX [recombinant] (Idelvion) coagulation factor IX (recombinant), Fc fusionprotein (Alprolix) coagulation factor IX [recombinant] (Ixinity) coagulation...
potential to treat these diseases by inhibiting TNF-alpha. Etanercept is a fusionprotein produced by recombinant DNA. It fuses the TNF receptor to the constant...
(FBR-MuSV). It encodes a fusionprotein consisting of the ubiquitin-like protein FUBI at the N-terminus and ribosomal protein S30 at the C-terminus. It...
translocation events that lead to a fusion between a proto-oncogene and a 2nd gene (this creates a fusionprotein with increased cancerous/oncogenic activity)...
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