FBLN1 information

FBLN1
Identifiers
Aliases	FBLN1, FBLN, FIBL1, fibulin 1
External IDs	OMIM: 135820; MGI: 95487; HomoloGene: 21295; GeneCards: FBLN1; OMA:FBLN1 - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	45,601,135 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	85,170,736 bp
RNA expression pattern
	Top expressed in
	canal of the cervix; ; gallbladder; ; vena cava; ; pericardium; ; gastric mucosa; ; ectocervix; ; vagina; ; left uterine tube; ; right auricle; ; tendon of biceps brachii;
	Top expressed in
	aortic valve; ; otic vesicle; ; ascending aorta; ; otic placode; ; ciliary body; ; external carotid artery; ; saccule; ; mandibular prominence; ; internal carotid artery; ; maxillary prominence;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	fibronectin binding; calcium ion binding; extracellular matrix structural constituent; fibrinogen binding; integrin binding; protein C-terminus binding; protein binding; identical protein binding; peptidase activator activity; protein-containing complex binding;
Cellular component	elastic fiber; extracellular matrix; fibrinogen complex; basement membrane; extracellular exosome; extracellular space; extracellular region; collagen-containing extracellular matrix;
Biological process	negative regulation of protein phosphorylation; negative regulation of cell adhesion; negative regulation of stem cell proliferation; positive regulation of fibroblast proliferation; positive regulation of substrate-dependent cell migration, cell attachment to substrate; negative regulation of cell motility; negative regulation of transformation of host cell by virus; positive regulation of peptidase activity; positive regulation of gene expression; negative regulation of ERK1 and ERK2 cascade; integrin-mediated signaling pathway; blood coagulation, fibrin clot formation; negative regulation of substrate adhesion-dependent cell spreading; viral process; embryo implantation; extracellular matrix organization;
	Sources:Amigo / QuickGO
Orthologs
	2192
	14114
	ENSG00000077942
	ENSMUSG00000006369
	P23142
	Q08879
	NM_006487; NM_001996; NM_006485; NM_006486
	NM_010180; NM_001347088
	NP_001987; NP_006476; NP_006477; NP_006478
	NP_001334017; NP_034310
	Wikidata
View/Edit Human	View/Edit Mouse

FBLN1 is the gene encoding fibulin-1, an extracellular matrix and plasma protein.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000077942 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000006369 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: FBLN1 fibulin 1".
^ Argraves WS, Tran H, Burgess WH, Dickerson K (Dec 1990). "Fibulin is an extracellular matrix and plasma glycoprotein with repeated domain structure". The Journal of Cell Biology. 111 (6 Pt 2): 3155–64. doi:10.1083/jcb.111.6.3155. PMC 2116371. PMID 2269669.
^ Balbona K, Tran H, Godyna S, Ingham KC, Strickland DK, Argraves WS (Oct 1992). "Fibulin binds to itself and to the carboxyl-terminal heparin-binding region of fibronectin". The Journal of Biological Chemistry. 267 (28): 20120–5. doi:10.1016/S0021-9258(19)88674-X. PMID 1400330.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000077942 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000006369 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: FBLN1 fibulin 1".

[pmid2269669-6] Argraves WS, Tran H, Burgess WH, Dickerson K (Dec 1990). "Fibulin is an extracellular matrix and plasma glycoprotein with repeated domain structure". The Journal of Cell Biology. 111 (6 Pt 2): 3155–64. doi:10.1083/jcb.111.6.3155. PMC 2116371. PMID 2269669.

[pmid1400330-7] Balbona K, Tran H, Godyna S, Ingham KC, Strickland DK, Argraves WS (Oct 1992). "Fibulin binds to itself and to the carboxyl-terminal heparin-binding region of fibronectin". The Journal of Biological Chemistry. 267 (28): 20120–5. doi:10.1016/S0021-9258(19)88674-X. PMID 1400330.

FBLN1 information

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FBLN1

Anaphylatoxin

Synpolydactyly

22q13 deletion syndrome

Chromosome 22

Inositol trisphosphate

Fibulin

Calmodulin

Calpain

Calsequestrin

Ryanodine receptor

Osteocalcin

Calreticulin

Calbindin

Annexin

Phospholamban

Annexin A5

Calnexin

Metastasis suppressor

Troponin C

S100 protein

Calretinin

Synaptotagmin

Calcium signaling

Calgranulin