Estazolam information

Estazolam
Clinical data
Trade names	Prosom, Esilgan, Eurodin, Nuctalon, others
Other names	Desmethylalprazolam
AHFS/Drugs.com	Monograph
MedlinePlus	a691003
License data	US DailyMed: Estazolam;
Routes of; administration	By mouth
ATC code	N05CD04 (WHO) ;
Legal status
Legal status	BR: Class B1 (Psychoactive drugs); CA: Schedule IV; DE: Prescription only (Anlage III for higher doses); UK: Class C; US: WARNINGSchedule IV;
Pharmacokinetic data
Bioavailability	93%
Metabolism	Liver
Elimination half-life	10–24 hours
Excretion	Kidney
Identifiers
	IUPAC name 8-chloro-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine;
CAS Number	29975-16-4 ;
PubChem CID	3261;
IUPHAR/BPS	7550;
DrugBank	DB01215 ;
ChemSpider	3146 ;
UNII	36S3EQV54C;
KEGG	D00311 ;
ChEBI	CHEBI:4858 ;
ChEMBL	ChEMBL285674 ;
CompTox Dashboard (EPA)	DTXSID5020572 ;
ECHA InfoCard	100.045.424
Chemical and physical data
Formula	C16H11ClN4
Molar mass	294.74 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES ClC1=CC2=C(C=C1)N3C=NN=C3CN=C2C4=CC=CC=C4;
	InChI InChI=1S/C16H11ClN4/c17-12-6-7-14-13(8-12)16(11-4-2-1-3-5-11)18-9-15-20-19-10-21(14)15/h1-8,10H,9H2 ; Key:CDCHDCWJMGXXRH-UHFFFAOYSA-N ;
	(verify)

Estazolam, sold under the brand name Prosom among others, is a tranquilizer medication of the triazolobenzodiazepine (TBZD) class, which are benzodiazepines (BZDs) fused with a triazole ring. It possesses anxiolytic, anticonvulsant, hypnotic, sedative and skeletal muscle relaxant properties. Estazolam is an intermediate-acting oral benzodiazepine. It is used for short-term treatment of insomnia.

It was patented in 1968 and came into medical use in 1975.^[5]

^ "FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 Oct 2023.
^ Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16.
^ Cite error: The named reference Estazolam FDA label was invoked but never defined (see the help page).
^ "Estazolam (Prosom) Use During Pregnancy". Drugs.com. 18 September 2020. Retrieved 25 October 2020.
^ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 538. ISBN 9783527607495.

[FDA-AllBoxedWarnings-1] "FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 Oct 2023.

[2] Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16.

[Estazolam_FDA_label-3] Cite error: The named reference Estazolam FDA label was invoked but never defined (see the help page).

[Drugs.com_pregnancy-4] "Estazolam (Prosom) Use During Pregnancy". Drugs.com. 18 September 2020. Retrieved 25 October 2020.

[Fis2006-5] Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 538. ISBN 9783527607495.

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